Otomicroscopic findings and systemic interleukin-6 levels in relation to etiologic agent during experimental acute otitis media
(2006) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 114(4). p.285-291- Abstract
- The aim of the present study was to explore whether it was possible to differentiate the clinical course and the otomicroscopic appearance of acute otitis media (AOM) caused by common otitis pathogens in an animal model. Systemic interleukin (IL)-6 levels as early markers for bacterial AOM were also studied. Four groups of rats were inoculated with either Streptococcus pneumoniae, Streptococcus pyogenes, non-typeable Haemophilus influenzae or Moraxella catarrhalis. The animals were monitored by otomicroscopy, photos of the tympanic membrane, cultures and IL-6 detection in serum the following 4 days. The gram-positive S. pneumoniae and S. pyogenes induced severe AOM with opaque effusion behind the tympanic membrane, pronounced dilation of... (More)
- The aim of the present study was to explore whether it was possible to differentiate the clinical course and the otomicroscopic appearance of acute otitis media (AOM) caused by common otitis pathogens in an animal model. Systemic interleukin (IL)-6 levels as early markers for bacterial AOM were also studied. Four groups of rats were inoculated with either Streptococcus pneumoniae, Streptococcus pyogenes, non-typeable Haemophilus influenzae or Moraxella catarrhalis. The animals were monitored by otomicroscopy, photos of the tympanic membrane, cultures and IL-6 detection in serum the following 4 days. The gram-positive S. pneumoniae and S. pyogenes induced severe AOM with opaque effusion behind the tympanic membrane, pronounced dilation of the vessels and spontaneous perforations. The gram-negative H. influenzae and M. catarrhalis induced a less severe infection with cloudy, sometimes foamy effusion, and no spontaneous perforations. With the otomicroscopic findings it was possible to distinguish between infections induced by gram-positive bacteria and gram-negative bacteria. Detection of interleukin-6 in serum appeared to be of limited use for all infections except the pneumococcal AOM, but this needs to be further investigated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/410570
- author
- Fogle-Hansson, M ; White, Peter LU ; Hermansson, Ann LU and Melhus, A
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- otomicroscopy, IL-6, diagnosis, acute otitis media, animal model
- in
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- volume
- 114
- issue
- 4
- pages
- 285 - 291
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000237302500007
- pmid:16689828
- scopus:33646498074
- ISSN
- 1600-0463
- DOI
- 10.1111/j.1600-0463.2006.apm_297.x
- language
- English
- LU publication?
- yes
- id
- a769638f-cf51-4c26-bde2-429e99e85e2f (old id 410570)
- date added to LUP
- 2016-04-01 12:03:32
- date last changed
- 2022-01-26 22:12:55
@article{a769638f-cf51-4c26-bde2-429e99e85e2f,
abstract = {{The aim of the present study was to explore whether it was possible to differentiate the clinical course and the otomicroscopic appearance of acute otitis media (AOM) caused by common otitis pathogens in an animal model. Systemic interleukin (IL)-6 levels as early markers for bacterial AOM were also studied. Four groups of rats were inoculated with either Streptococcus pneumoniae, Streptococcus pyogenes, non-typeable Haemophilus influenzae or Moraxella catarrhalis. The animals were monitored by otomicroscopy, photos of the tympanic membrane, cultures and IL-6 detection in serum the following 4 days. The gram-positive S. pneumoniae and S. pyogenes induced severe AOM with opaque effusion behind the tympanic membrane, pronounced dilation of the vessels and spontaneous perforations. The gram-negative H. influenzae and M. catarrhalis induced a less severe infection with cloudy, sometimes foamy effusion, and no spontaneous perforations. With the otomicroscopic findings it was possible to distinguish between infections induced by gram-positive bacteria and gram-negative bacteria. Detection of interleukin-6 in serum appeared to be of limited use for all infections except the pneumococcal AOM, but this needs to be further investigated.}},
author = {{Fogle-Hansson, M and White, Peter and Hermansson, Ann and Melhus, A}},
issn = {{1600-0463}},
keywords = {{otomicroscopy; IL-6; diagnosis; acute otitis media; animal model}},
language = {{eng}},
number = {{4}},
pages = {{285--291}},
publisher = {{John Wiley & Sons Inc.}},
series = {{APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}},
title = {{Otomicroscopic findings and systemic interleukin-6 levels in relation to etiologic agent during experimental acute otitis media}},
url = {{http://dx.doi.org/10.1111/j.1600-0463.2006.apm_297.x}},
doi = {{10.1111/j.1600-0463.2006.apm_297.x}},
volume = {{114}},
year = {{2006}},
}