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Parathyroid hormone for bone repair and implant fixation - Experiment in rats

Skripitz, Ralf LU (2001)
Abstract
Intermittently administered PTH is known to increase bone mass in osteoporosis models. We studied its effects in bone repair and implant fixation, using histological and mechanical techniques in rats. In a bone chamber, PTH substantially increased the density of the new-formed bone, whereas there was only a minor effect on the pre-existing bone in the L5 vertebra or femur. Considering that PTH increased bone density especially at a site of regeneration, we evaluated the possibility of enhancing bone-implant fixation using PTH. Rats received a screw in each proximal tibia. PTH increased the removal torque three-fold at 4 weeks and doubled the pull-out strength. A similar effect was seen also at 2 weeks, and at 1 week histology showed that... (More)
Intermittently administered PTH is known to increase bone mass in osteoporosis models. We studied its effects in bone repair and implant fixation, using histological and mechanical techniques in rats. In a bone chamber, PTH substantially increased the density of the new-formed bone, whereas there was only a minor effect on the pre-existing bone in the L5 vertebra or femur. Considering that PTH increased bone density especially at a site of regeneration, we evaluated the possibility of enhancing bone-implant fixation using PTH. Rats received a screw in each proximal tibia. PTH increased the removal torque three-fold at 4 weeks and doubled the pull-out strength. A similar effect was seen also at 2 weeks, and at 1 week histology showed that PTH increased the fraction of the metal surface having contact with bone without an intervening soft tissue layer from half to two thirds. A detachment test determine how PTH administration influences the bone-cement interfacial tensile strength. We used unloaded cement surfaces, which could be detached from the bone. PTH increased the median pull-away strength five-fold at 4 weeks. In conclusion, intermittent PTH treatment has a potential for enhancing the fixation of uncemented and cemented orthopedic implants due to its ability to increase bone density, especially at sites undergoing repair or regeneration. (Less)
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author
supervisor
opponent
  • Professor Boström, Mathias
organization
publishing date
type
Thesis
publication status
published
subject
keywords
PMMA-cement, torque, tensile tesst, Bone conduction chamber, PTH, rats, Surgery, orthopaedics, traumatology, Kirurgi, ortopedi, traumatologi
pages
60 pages
publisher
Department of Orthopaedics, Lund University
defense location
University Hospital, Lund
defense date
2001-03-14 10:15:00
language
English
LU publication?
yes
id
fbf19bbb-0601-4cab-bc90-e958c148d219 (old id 41278)
date added to LUP
2016-04-04 11:16:33
date last changed
2025-04-04 15:07:47
@phdthesis{fbf19bbb-0601-4cab-bc90-e958c148d219,
  abstract     = {{Intermittently administered PTH is known to increase bone mass in osteoporosis models. We studied its effects in bone repair and implant fixation, using histological and mechanical techniques in rats. In a bone chamber, PTH substantially increased the density of the new-formed bone, whereas there was only a minor effect on the pre-existing bone in the L5 vertebra or femur. Considering that PTH increased bone density especially at a site of regeneration, we evaluated the possibility of enhancing bone-implant fixation using PTH. Rats received a screw in each proximal tibia. PTH increased the removal torque three-fold at 4 weeks and doubled the pull-out strength. A similar effect was seen also at 2 weeks, and at 1 week histology showed that PTH increased the fraction of the metal surface having contact with bone without an intervening soft tissue layer from half to two thirds. A detachment test determine how PTH administration influences the bone-cement interfacial tensile strength. We used unloaded cement surfaces, which could be detached from the bone. PTH increased the median pull-away strength five-fold at 4 weeks. In conclusion, intermittent PTH treatment has a potential for enhancing the fixation of uncemented and cemented orthopedic implants due to its ability to increase bone density, especially at sites undergoing repair or regeneration.}},
  author       = {{Skripitz, Ralf}},
  keywords     = {{PMMA-cement; torque; tensile tesst; Bone conduction chamber; PTH; rats; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi}},
  language     = {{eng}},
  publisher    = {{Department of Orthopaedics, Lund University}},
  school       = {{Lund University}},
  title        = {{Parathyroid hormone for bone repair and implant fixation - Experiment in rats}},
  year         = {{2001}},
}