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Penicillin-resistant pneumococci in Sweden 1997-2003: Increased multiresistance despite stable prevalence and decreased antibiotic use

Hogberg, L ; Ekdahl, K ; Sjostrom, K ; Olsson-Liljequist, B ; Walder, Mats LU ; Melander, E ; Ringberg, H and Normark, BH (2006) In Microbial Drug Resistance 12(1). p.16-22
Abstract
Antimicrobial resistance patterns and capsular groups of penicillin-resistant Streptococcus pneumoniae (PRP; MIC penicillin G >= 0.5 mg/ml) in Sweden between 1997 and 2003 were described, and trends in resistance and antibiotic sales during the same period were compared. The most common serogroups were in descending order 9, 19, 14, 23, and 6. Despite a low and stable annual PRP rate (proportion of PRP out of all pneumococci) of around 2% during the study period, the proportion of PRP resistant to other antibiotics increased. Of all tested PRP isolates, 82% were also resistant to trimethoprim/sulfamethoxazole, 32% had additional resistance to tetracycline, and 26% to erythromycin. Antibiotic sales figures for all studied antibiotic... (More)
Antimicrobial resistance patterns and capsular groups of penicillin-resistant Streptococcus pneumoniae (PRP; MIC penicillin G >= 0.5 mg/ml) in Sweden between 1997 and 2003 were described, and trends in resistance and antibiotic sales during the same period were compared. The most common serogroups were in descending order 9, 19, 14, 23, and 6. Despite a low and stable annual PRP rate (proportion of PRP out of all pneumococci) of around 2% during the study period, the proportion of PRP resistant to other antibiotics increased. Of all tested PRP isolates, 82% were also resistant to trimethoprim/sulfamethoxazole, 32% had additional resistance to tetracycline, and 26% to erythromycin. Antibiotic sales figures for all studied antibiotic subgroups decreased during the same period. Little correlation was found between antibiotic sales and PRP resistance rates, indicating that there are still other poorly defined factors contributing to the reported resistance levels in the population. However, although PRP strains in Sweden are becoming more commonly resistant to antibiotics other than beta-lactams, the low and further reduced antibiotic sales still might have delayed the development and rapid spread of PRP in the population. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Microbial Drug Resistance
volume
12
issue
1
pages
16 - 22
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000236686300004
  • scopus:33646028165
ISSN
1076-6294
DOI
10.1089/mdr.2006.12.16
language
English
LU publication?
yes
id
9e5fcd85-3efa-4e1d-ac18-6bc796f86032 (old id 413971)
date added to LUP
2016-04-01 16:12:37
date last changed
2020-01-12 19:08:44
@article{9e5fcd85-3efa-4e1d-ac18-6bc796f86032,
  abstract     = {Antimicrobial resistance patterns and capsular groups of penicillin-resistant Streptococcus pneumoniae (PRP; MIC penicillin G >= 0.5 mg/ml) in Sweden between 1997 and 2003 were described, and trends in resistance and antibiotic sales during the same period were compared. The most common serogroups were in descending order 9, 19, 14, 23, and 6. Despite a low and stable annual PRP rate (proportion of PRP out of all pneumococci) of around 2% during the study period, the proportion of PRP resistant to other antibiotics increased. Of all tested PRP isolates, 82% were also resistant to trimethoprim/sulfamethoxazole, 32% had additional resistance to tetracycline, and 26% to erythromycin. Antibiotic sales figures for all studied antibiotic subgroups decreased during the same period. Little correlation was found between antibiotic sales and PRP resistance rates, indicating that there are still other poorly defined factors contributing to the reported resistance levels in the population. However, although PRP strains in Sweden are becoming more commonly resistant to antibiotics other than beta-lactams, the low and further reduced antibiotic sales still might have delayed the development and rapid spread of PRP in the population.},
  author       = {Hogberg, L and Ekdahl, K and Sjostrom, K and Olsson-Liljequist, B and Walder, Mats and Melander, E and Ringberg, H and Normark, BH},
  issn         = {1076-6294},
  language     = {eng},
  number       = {1},
  pages        = {16--22},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Microbial Drug Resistance},
  title        = {Penicillin-resistant pneumococci in Sweden 1997-2003: Increased multiresistance despite stable prevalence and decreased antibiotic use},
  url          = {http://dx.doi.org/10.1089/mdr.2006.12.16},
  doi          = {10.1089/mdr.2006.12.16},
  volume       = {12},
  year         = {2006},
}