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Heparan sulfate proteoglycan as a cell-surface endocytosis receptor.

Christianson, Helena LU and Belting, Mattias LU (2014) In Matrix Biology 35(Oct 18). p.51-55
Abstract
How various macromolecules are exchanged between cells and how they gain entry into recipient cells are fundamental questions in cell biology with important implications e.g. non-viral drug delivery, infectious disease, metabolic disorders, and cancer. The role of heparan sulfate proteoglycan (HSPG) as a cell-surface receptor of diverse macromolecular cargo has recently been manifested. Exosomes, cell penetrating peptides, polycation-nucleic acid complexes, viruses, lipoproteins, growth factors and morphogens among other ligands enter cells through HSPG-mediated endocytosis. Key questions that partially have been unraveled over recent years include the respective roles of HSPG core protein and HS chain structure specificity for... (More)
How various macromolecules are exchanged between cells and how they gain entry into recipient cells are fundamental questions in cell biology with important implications e.g. non-viral drug delivery, infectious disease, metabolic disorders, and cancer. The role of heparan sulfate proteoglycan (HSPG) as a cell-surface receptor of diverse macromolecular cargo has recently been manifested. Exosomes, cell penetrating peptides, polycation-nucleic acid complexes, viruses, lipoproteins, growth factors and morphogens among other ligands enter cells through HSPG-mediated endocytosis. Key questions that partially have been unraveled over recent years include the respective roles of HSPG core protein and HS chain structure specificity for macromolecular cargo endocytosis, the down-stream intracellular signaling events involved in HSPG-dependent membrane invagination and vesicle formation, and the biological significance of the HSPG transport pathway. Here, we discuss the intriguing role of HSPGs as a major entry pathway of macromolecules in mammalian cells with emphasis on recent in vitro and in vivo data that provide compelling evidence of HSPG as an autonomous endocytosis receptor. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Matrix Biology
volume
35
issue
Oct 18
pages
51 - 55
publisher
Elsevier
external identifiers
  • pmid:24145152
  • wos:000337556500009
  • scopus:84901426479
ISSN
1569-1802
DOI
10.1016/j.matbio.2013.10.004
language
English
LU publication?
yes
id
8f65b60d-e8c5-4fdc-b835-e9344d8f8379 (old id 4143136)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24145152?dopt=Abstract
date added to LUP
2013-11-04 23:21:34
date last changed
2017-11-12 03:14:26
@article{8f65b60d-e8c5-4fdc-b835-e9344d8f8379,
  abstract     = {How various macromolecules are exchanged between cells and how they gain entry into recipient cells are fundamental questions in cell biology with important implications e.g. non-viral drug delivery, infectious disease, metabolic disorders, and cancer. The role of heparan sulfate proteoglycan (HSPG) as a cell-surface receptor of diverse macromolecular cargo has recently been manifested. Exosomes, cell penetrating peptides, polycation-nucleic acid complexes, viruses, lipoproteins, growth factors and morphogens among other ligands enter cells through HSPG-mediated endocytosis. Key questions that partially have been unraveled over recent years include the respective roles of HSPG core protein and HS chain structure specificity for macromolecular cargo endocytosis, the down-stream intracellular signaling events involved in HSPG-dependent membrane invagination and vesicle formation, and the biological significance of the HSPG transport pathway. Here, we discuss the intriguing role of HSPGs as a major entry pathway of macromolecules in mammalian cells with emphasis on recent in vitro and in vivo data that provide compelling evidence of HSPG as an autonomous endocytosis receptor.},
  author       = {Christianson, Helena and Belting, Mattias},
  issn         = {1569-1802},
  language     = {eng},
  number       = {Oct 18},
  pages        = {51--55},
  publisher    = {Elsevier},
  series       = {Matrix Biology},
  title        = {Heparan sulfate proteoglycan as a cell-surface endocytosis receptor.},
  url          = {http://dx.doi.org/10.1016/j.matbio.2013.10.004},
  volume       = {35},
  year         = {2014},
}