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Ceruloplasmin and atrial fibrillation: evidence of causality from a population-based Mendelian randomization study.

Adamsson Eryd, Samuel LU ; Sjögren, Marketa LU ; Smith, Gustav LU ; Nilsson, Peter LU ; Melander, Olle LU ; Hedblad, Bo LU and Engström, Gunnar LU (2014) In Journal of Internal Medicine 275(2). p.164-171
Abstract
Inflammatory diseases and inflammatory markers secreted by the liver, including C-reactive protein (CRP) and ceruloplasmin, have been associated with incident atrial fibrillation (AF). Genetic studies have not supported a causal relationship between CRP and AF, but the relationship between ceruloplasmin and AF has not been studied. The purpose of this Mendelian randomization study was to explore whether genetic polymorphisms in the gene encoding ceruloplasmin are associated with elevated ceruloplasmin levels, and whether such genetic polymorphisms are also associated with the incidence of AF.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
275
issue
2
pages
164 - 171
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000329764500008
  • pmid:24118451
  • scopus:84892537762
ISSN
1365-2796
DOI
10.1111/joim.12144
language
English
LU publication?
yes
id
caa0136c-244e-4a1a-b288-ed9faf4758f9 (old id 4143356)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24118451?dopt=Abstract
date added to LUP
2013-11-05 19:39:20
date last changed
2017-06-18 03:10:43
@article{caa0136c-244e-4a1a-b288-ed9faf4758f9,
  abstract     = {Inflammatory diseases and inflammatory markers secreted by the liver, including C-reactive protein (CRP) and ceruloplasmin, have been associated with incident atrial fibrillation (AF). Genetic studies have not supported a causal relationship between CRP and AF, but the relationship between ceruloplasmin and AF has not been studied. The purpose of this Mendelian randomization study was to explore whether genetic polymorphisms in the gene encoding ceruloplasmin are associated with elevated ceruloplasmin levels, and whether such genetic polymorphisms are also associated with the incidence of AF.},
  author       = {Adamsson Eryd, Samuel and Sjögren, Marketa and Smith, Gustav and Nilsson, Peter and Melander, Olle and Hedblad, Bo and Engström, Gunnar},
  issn         = {1365-2796},
  language     = {eng},
  number       = {2},
  pages        = {164--171},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine},
  title        = {Ceruloplasmin and atrial fibrillation: evidence of causality from a population-based Mendelian randomization study.},
  url          = {http://dx.doi.org/10.1111/joim.12144},
  volume       = {275},
  year         = {2014},
}