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miRNAs in brain development.

Petri, Rebecca LU ; Malmevik, Josephine LU ; Fasching, Liana LU ; Åkerblom, Malin LU and Jakobsson, Johan LU (2014) In Experimental Cell Research 321(1). p.84-89
Abstract
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as... (More)
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Cell Research
volume
321
issue
1
pages
84 - 89
publisher
Academic Press
external identifiers
  • pmid:24099990
  • wos:000331157200013
  • scopus:84892548938
ISSN
1090-2422
DOI
10.1016/j.yexcr.2013.09.022
language
English
LU publication?
yes
id
94be29e9-70e6-47ab-813c-a9873d617be4 (old id 4143614)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24099990?dopt=Abstract
date added to LUP
2013-11-02 21:44:54
date last changed
2017-08-13 03:06:59
@article{94be29e9-70e6-47ab-813c-a9873d617be4,
  abstract     = {MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development.},
  author       = {Petri, Rebecca and Malmevik, Josephine and Fasching, Liana and Åkerblom, Malin and Jakobsson, Johan},
  issn         = {1090-2422},
  language     = {eng},
  number       = {1},
  pages        = {84--89},
  publisher    = {Academic Press},
  series       = {Experimental Cell Research},
  title        = {miRNAs in brain development.},
  url          = {http://dx.doi.org/10.1016/j.yexcr.2013.09.022},
  volume       = {321},
  year         = {2014},
}