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In utero exposure to persistent organic pollutants in relation to testicular cancer risk

Hardell, L ; van Bavel, B ; Lindstrom, G ; Eriksson, Mikael LU orcid and Carlberg, M (2006) In International Journal of Andrology 29(1). p.228-234
Abstract
Testicular cancer is the most common tumour type in young men. In Sweden the annual age-adjusted incidence increased significantly by 2.4% during the time period 1984-1993 and during 1994-2003 by 1.4%. Exposure to endocrine disrupting chemicals during the foetal period has been postulated to be a risk factor. In this investigation we studied the concentrations of chlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene (pp'-DDE), hexachlorobenzene (HCB), chlordanes and polybrominated diphenylethers (PBDEs) in 58 cases with testicular cancer and 61 age-matched controls. Furthermore, case and control mothers were also asked to participate and 44 case mothers and 45 control mothers agreed. No significant differences were found... (More)
Testicular cancer is the most common tumour type in young men. In Sweden the annual age-adjusted incidence increased significantly by 2.4% during the time period 1984-1993 and during 1994-2003 by 1.4%. Exposure to endocrine disrupting chemicals during the foetal period has been postulated to be a risk factor. In this investigation we studied the concentrations of chlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene (pp'-DDE), hexachlorobenzene (HCB), chlordanes and polybrominated diphenylethers (PBDEs) in 58 cases with testicular cancer and 61 age-matched controls. Furthermore, case and control mothers were also asked to participate and 44 case mothers and 45 control mothers agreed. No significant differences were found between cases and controls. Case mothers had in general higher concentrations of these chemicals. For the sum of PCBs an odds ratio (OR) = 3.8, 95% confidence interval (CI) = 1.4-10 was calculated using the median concentration for the controls as cut-off value. For HCB OR = 4.4, CI = 1.7-12 and for PBDE OR = 2.5, 95% Cl = 1.02-6.0 were obtained, whereas OR was not significantly increased for pp'-DDE and sum of chlordanes. The cases were born during a period with high concentrations of persistent organic pollutants (POPs) in humans. The decline of the increasing incidence of testicular cancer during recent years may reflect decreasing body burden of certain POPs since the 1980s. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
testicular cancer, polychlorinated biphenyls, pollutants, persistent organic, perinatal exposure, aetiology, incidence
in
International Journal of Andrology
volume
29
issue
1
pages
228 - 234
publisher
Wiley-Blackwell
external identifiers
  • wos:000236542000056
  • pmid:16371110
  • scopus:33645213020
ISSN
0105-6263
DOI
10.1111/j.1365-2605.2005.00622.x
language
English
LU publication?
yes
id
a9835153-3255-4096-bdc4-2e77b9e356fa (old id 414489)
date added to LUP
2016-04-01 16:31:27
date last changed
2021-02-02 04:23:58
@article{a9835153-3255-4096-bdc4-2e77b9e356fa,
  abstract     = {Testicular cancer is the most common tumour type in young men. In Sweden the annual age-adjusted incidence increased significantly by 2.4% during the time period 1984-1993 and during 1994-2003 by 1.4%. Exposure to endocrine disrupting chemicals during the foetal period has been postulated to be a risk factor. In this investigation we studied the concentrations of chlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene (pp'-DDE), hexachlorobenzene (HCB), chlordanes and polybrominated diphenylethers (PBDEs) in 58 cases with testicular cancer and 61 age-matched controls. Furthermore, case and control mothers were also asked to participate and 44 case mothers and 45 control mothers agreed. No significant differences were found between cases and controls. Case mothers had in general higher concentrations of these chemicals. For the sum of PCBs an odds ratio (OR) = 3.8, 95% confidence interval (CI) = 1.4-10 was calculated using the median concentration for the controls as cut-off value. For HCB OR = 4.4, CI = 1.7-12 and for PBDE OR = 2.5, 95% Cl = 1.02-6.0 were obtained, whereas OR was not significantly increased for pp'-DDE and sum of chlordanes. The cases were born during a period with high concentrations of persistent organic pollutants (POPs) in humans. The decline of the increasing incidence of testicular cancer during recent years may reflect decreasing body burden of certain POPs since the 1980s.},
  author       = {Hardell, L and van Bavel, B and Lindstrom, G and Eriksson, Mikael and Carlberg, M},
  issn         = {0105-6263},
  language     = {eng},
  number       = {1},
  pages        = {228--234},
  publisher    = {Wiley-Blackwell},
  series       = {International Journal of Andrology},
  title        = {In utero exposure to persistent organic pollutants in relation to testicular cancer risk},
  url          = {http://dx.doi.org/10.1111/j.1365-2605.2005.00622.x},
  doi          = {10.1111/j.1365-2605.2005.00622.x},
  volume       = {29},
  year         = {2006},
}