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Newborns discriminate novel from harmonic sounds: A study using magnetoencephalography

Sambeth, A ; Huotilainen, M ; Kushnerenko, E ; Fellman, Vineta LU orcid and Pihko, E (2006) In Clinical Neurophysiology 117(3). p.496-503
Abstract
Objective: We investigated whether newborns respond differently to novel and deviant sounds during quiet sleep. Methods: Twelve healthy neonates were presented with a three-stimulus oddball paradigm, consisting of frequent standard (76%), infrequent deviant (12%), and infrequent novel stimuli (12%). The standards and deviants were counterbalanced between the newborns and consisted of 500 and 750 Hz tones with two upper harmonics. The novel stimuli contained animal, human, and mechanical sounds. All stimuli had a duration of 300 ms and the stimulus onset asynchrony was 1 s. Evoked magnetic responses during quiet sleep were recorded and averaged offline. Results: Two deflections peaking at 345 and 615 ms after stimulus onset were observed in... (More)
Objective: We investigated whether newborns respond differently to novel and deviant sounds during quiet sleep. Methods: Twelve healthy neonates were presented with a three-stimulus oddball paradigm, consisting of frequent standard (76%), infrequent deviant (12%), and infrequent novel stimuli (12%). The standards and deviants were counterbalanced between the newborns and consisted of 500 and 750 Hz tones with two upper harmonics. The novel stimuli contained animal, human, and mechanical sounds. All stimuli had a duration of 300 ms and the stimulus onset asynchrony was 1 s. Evoked magnetic responses during quiet sleep were recorded and averaged offline. Results: Two deflections peaking at 345 and 615 ms after stimulus onset were observed in the evoked responses of most of the newborns. The first deflection was larger to novel and deviant stimuli than to the standard and, furthermore, larger to novel than to deviant stimuli. The second deflection was larger to novel and deviant stimuli than to standards, but did not differ between the novels and deviants. Conclusions: The two deflections found in the present study reflect different mechanisms of auditory change detection and discriminative processes. Significance: The early brain indicators of novelty detection may be crucial in assessing the normal and abnormal cortical function in newborns. Further, studying evoked magnetic fields to complex auditory stimulation in healthy newborns is needed for studying the newborns at-risk for cognitive or language problems. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
novelty, newborn, magnetoencephalography, auditory, change detection, oddball
in
Clinical Neurophysiology
volume
117
issue
3
pages
496 - 503
publisher
Elsevier
external identifiers
  • pmid:16426892
  • wos:000236567700004
  • scopus:33644770397
ISSN
1872-8952
DOI
10.1016/j.clinph.2005.11.008
language
English
LU publication?
yes
id
5f131efb-171b-4567-8275-4d99050ca922 (old id 414580)
date added to LUP
2016-04-01 12:07:03
date last changed
2020-12-01 03:34:53
@article{5f131efb-171b-4567-8275-4d99050ca922,
  abstract     = {Objective: We investigated whether newborns respond differently to novel and deviant sounds during quiet sleep. Methods: Twelve healthy neonates were presented with a three-stimulus oddball paradigm, consisting of frequent standard (76%), infrequent deviant (12%), and infrequent novel stimuli (12%). The standards and deviants were counterbalanced between the newborns and consisted of 500 and 750 Hz tones with two upper harmonics. The novel stimuli contained animal, human, and mechanical sounds. All stimuli had a duration of 300 ms and the stimulus onset asynchrony was 1 s. Evoked magnetic responses during quiet sleep were recorded and averaged offline. Results: Two deflections peaking at 345 and 615 ms after stimulus onset were observed in the evoked responses of most of the newborns. The first deflection was larger to novel and deviant stimuli than to the standard and, furthermore, larger to novel than to deviant stimuli. The second deflection was larger to novel and deviant stimuli than to standards, but did not differ between the novels and deviants. Conclusions: The two deflections found in the present study reflect different mechanisms of auditory change detection and discriminative processes. Significance: The early brain indicators of novelty detection may be crucial in assessing the normal and abnormal cortical function in newborns. Further, studying evoked magnetic fields to complex auditory stimulation in healthy newborns is needed for studying the newborns at-risk for cognitive or language problems. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.},
  author       = {Sambeth, A and Huotilainen, M and Kushnerenko, E and Fellman, Vineta and Pihko, E},
  issn         = {1872-8952},
  language     = {eng},
  number       = {3},
  pages        = {496--503},
  publisher    = {Elsevier},
  series       = {Clinical Neurophysiology},
  title        = {Newborns discriminate novel from harmonic sounds: A study using magnetoencephalography},
  url          = {http://dx.doi.org/10.1016/j.clinph.2005.11.008},
  doi          = {10.1016/j.clinph.2005.11.008},
  volume       = {117},
  year         = {2006},
}