Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity
(2017) In Proceedings of the National Academy of Sciences of the United States of America 114(33). p.8776-8781- Abstract
Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like 1 (BMAL1), and transcriptional repressors cryptochrome (CRY) and period (PER). CRY1 and CRY2 bind independently of other core clock factors to many genomic sites, which are enriched for NR recognition motifs. Here we report that CRY1/2 serve as corepressors for many NRs,... (More)
Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like 1 (BMAL1), and transcriptional repressors cryptochrome (CRY) and period (PER). CRY1 and CRY2 bind independently of other core clock factors to many genomic sites, which are enriched for NR recognition motifs. Here we report that CRY1/2 serve as corepressors for many NRs, indicating a new facet of circadian control of NR-mediated regulation of metabolism and physiology, and specifically contribute to diurnal modulation of drug metabolism.
(Less)
- author
- organization
- publishing date
- 2017-08-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Circadian, Corepressor, Cryptochrome, Nuclear hormone receptor, Xenobiotic metabolism
- in
- Proceedings of the National Academy of Sciences of the United States of America
- volume
- 114
- issue
- 33
- pages
- 6 pages
- publisher
- National Academy of Sciences
- external identifiers
-
- pmid:28751364
- wos:000407610400061
- scopus:85027396367
- ISSN
- 0027-8424
- DOI
- 10.1073/pnas.1704955114
- language
- English
- LU publication?
- no
- id
- 41515e62-5f8d-4362-acd1-8472f259a605
- date added to LUP
- 2017-08-29 12:54:30
- date last changed
- 2024-04-14 16:28:44
@article{41515e62-5f8d-4362-acd1-8472f259a605, abstract = {{<p>Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like 1 (BMAL1), and transcriptional repressors cryptochrome (CRY) and period (PER). CRY1 and CRY2 bind independently of other core clock factors to many genomic sites, which are enriched for NR recognition motifs. Here we report that CRY1/2 serve as corepressors for many NRs, indicating a new facet of circadian control of NR-mediated regulation of metabolism and physiology, and specifically contribute to diurnal modulation of drug metabolism.</p>}}, author = {{Kriebs, Anna and Jordan, Sabine D. and Soto, Erin and Henriksson, Emma and Sandate, Colby R. and Vaughan, Megan E. and Chan, Alanna B. and Duglan, Drew and Papp, Stephanie J. and Huber, Anne Laure and Afetian, Megan E. and Yu, Ruth T. and Zhao, Xuan and Downes, Michael and Evans, Ronald M. and Lamia, Katja A}}, issn = {{0027-8424}}, keywords = {{Circadian; Corepressor; Cryptochrome; Nuclear hormone receptor; Xenobiotic metabolism}}, language = {{eng}}, month = {{08}}, number = {{33}}, pages = {{8776--8781}}, publisher = {{National Academy of Sciences}}, series = {{Proceedings of the National Academy of Sciences of the United States of America}}, title = {{Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity}}, url = {{http://dx.doi.org/10.1073/pnas.1704955114}}, doi = {{10.1073/pnas.1704955114}}, volume = {{114}}, year = {{2017}}, }