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Interactions between dendritic cells and epithelial cells in allergic disease

Roggen, EL ; Lindstedt, Malin LU ; Borrebaeck, Carl LU and Verheyen, GR (2006) 42nd Congress of the European Societies of Toxicology - EUROTOX 2005 162(1). p.71-82
Abstract
Dendritic cells (DCs) play a crucial role in the sensitisation process. Upon encounter with an allergen, DCs require interactions with other cells and factors for triggering a primary or secondary immune response. Epithelial cells (ECs) express features of accessory cells, Such as expression of HLA-DR, co-stimulatory molecules, functional Fc gamma R, molecules of the antigen-processing machinery, and display an ability to internalise antigen. These features may authorize them to function as immunomodulators (e.g. amplification of memory T cells during secondary immune responses). ECs may increase chemokine (e.g. CCL20) secretion thereby attracting DCs. Epithelial human TSLP activates DC, which allow them to prime naive T cell, for the... (More)
Dendritic cells (DCs) play a crucial role in the sensitisation process. Upon encounter with an allergen, DCs require interactions with other cells and factors for triggering a primary or secondary immune response. Epithelial cells (ECs) express features of accessory cells, Such as expression of HLA-DR, co-stimulatory molecules, functional Fc gamma R, molecules of the antigen-processing machinery, and display an ability to internalise antigen. These features may authorize them to function as immunomodulators (e.g. amplification of memory T cells during secondary immune responses). ECs may increase chemokine (e.g. CCL20) secretion thereby attracting DCs. Epithelial human TSLP activates DC, which allow them to prime naive T cell, for the production of pro-inflammatory cytokines, while down-regulating IFN-gamma and IL-10. ECs may also influence the local polarization of types 1 and 2 antigen-presenting cells via PGE(2) by impairing the ability of maturing DC to produce bioactive IL-12 p70. PGE(2) is synergistic with IL-1 beta and TNF-alpha in the induction of functional and phenotypic maturation of DC and induce IL12 p40 production. Sensitisation via the respiratory route may be Th-2 skewed, possibly because the antigen recognition by DC occurs in an environment rich of airway EC-product such its PGE(2). (c) 2005 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
dendric cells sensitisation, immunomodulation, allergic disease, immune response
host publication
Proceedings of the 42nd Congress of the European Societies of Toxicology - EUROTOX 2005 (Toxicology Letters)
volume
162
issue
1
pages
71 - 82
publisher
Elsevier
conference name
42nd Congress of the European Societies of Toxicology - EUROTOX 2005
conference location
Cracow, Poland
conference dates
2005-09-11 - 2005-09-14
external identifiers
  • pmid:16307851
  • wos:000236160300008
  • scopus:32644444111
ISSN
0378-4274
DOI
10.1016/j.toxlet.2005.10.013
language
English
LU publication?
yes
id
ed09354f-1e8d-4290-8009-9484b910ea39 (old id 415270)
date added to LUP
2016-04-01 16:42:08
date last changed
2021-02-17 06:30:17
@inproceedings{ed09354f-1e8d-4290-8009-9484b910ea39,
  abstract     = {Dendritic cells (DCs) play a crucial role in the sensitisation process. Upon encounter with an allergen, DCs require interactions with other cells and factors for triggering a primary or secondary immune response. Epithelial cells (ECs) express features of accessory cells, Such as expression of HLA-DR, co-stimulatory molecules, functional Fc gamma R, molecules of the antigen-processing machinery, and display an ability to internalise antigen. These features may authorize them to function as immunomodulators (e.g. amplification of memory T cells during secondary immune responses). ECs may increase chemokine (e.g. CCL20) secretion thereby attracting DCs. Epithelial human TSLP activates DC, which allow them to prime naive T cell, for the production of pro-inflammatory cytokines, while down-regulating IFN-gamma and IL-10. ECs may also influence the local polarization of types 1 and 2 antigen-presenting cells via PGE(2) by impairing the ability of maturing DC to produce bioactive IL-12 p70. PGE(2) is synergistic with IL-1 beta and TNF-alpha in the induction of functional and phenotypic maturation of DC and induce IL12 p40 production. Sensitisation via the respiratory route may be Th-2 skewed, possibly because the antigen recognition by DC occurs in an environment rich of airway EC-product such its PGE(2). (c) 2005 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Roggen, EL and Lindstedt, Malin and Borrebaeck, Carl and Verheyen, GR},
  booktitle    = {Proceedings of the 42nd Congress of the European Societies of Toxicology - EUROTOX 2005 (Toxicology Letters)},
  issn         = {0378-4274},
  language     = {eng},
  number       = {1},
  pages        = {71--82},
  publisher    = {Elsevier},
  title        = {Interactions between dendritic cells and epithelial cells in allergic disease},
  url          = {http://dx.doi.org/10.1016/j.toxlet.2005.10.013},
  doi          = {10.1016/j.toxlet.2005.10.013},
  volume       = {162},
  year         = {2006},
}