Interactions between dendritic cells and epithelial cells in allergic disease
(2006) 42nd Congress of the European Societies of Toxicology - EUROTOX 2005 162(1). p.71-82- Abstract
- Dendritic cells (DCs) play a crucial role in the sensitisation process. Upon encounter with an allergen, DCs require interactions with other cells and factors for triggering a primary or secondary immune response. Epithelial cells (ECs) express features of accessory cells, Such as expression of HLA-DR, co-stimulatory molecules, functional Fc gamma R, molecules of the antigen-processing machinery, and display an ability to internalise antigen. These features may authorize them to function as immunomodulators (e.g. amplification of memory T cells during secondary immune responses). ECs may increase chemokine (e.g. CCL20) secretion thereby attracting DCs. Epithelial human TSLP activates DC, which allow them to prime naive T cell, for the... (More)
- Dendritic cells (DCs) play a crucial role in the sensitisation process. Upon encounter with an allergen, DCs require interactions with other cells and factors for triggering a primary or secondary immune response. Epithelial cells (ECs) express features of accessory cells, Such as expression of HLA-DR, co-stimulatory molecules, functional Fc gamma R, molecules of the antigen-processing machinery, and display an ability to internalise antigen. These features may authorize them to function as immunomodulators (e.g. amplification of memory T cells during secondary immune responses). ECs may increase chemokine (e.g. CCL20) secretion thereby attracting DCs. Epithelial human TSLP activates DC, which allow them to prime naive T cell, for the production of pro-inflammatory cytokines, while down-regulating IFN-gamma and IL-10. ECs may also influence the local polarization of types 1 and 2 antigen-presenting cells via PGE(2) by impairing the ability of maturing DC to produce bioactive IL-12 p70. PGE(2) is synergistic with IL-1 beta and TNF-alpha in the induction of functional and phenotypic maturation of DC and induce IL12 p40 production. Sensitisation via the respiratory route may be Th-2 skewed, possibly because the antigen recognition by DC occurs in an environment rich of airway EC-product such its PGE(2). (c) 2005 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/415270
- author
- Roggen, EL ; Lindstedt, Malin LU ; Borrebaeck, Carl LU and Verheyen, GR
- organization
- publishing date
- 2006
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- dendric cells sensitisation, immunomodulation, allergic disease, immune response
- host publication
- Proceedings of the 42nd Congress of the European Societies of Toxicology - EUROTOX 2005 (Toxicology Letters)
- volume
- 162
- issue
- 1
- pages
- 71 - 82
- publisher
- Elsevier
- conference name
- 42nd Congress of the European Societies of Toxicology - EUROTOX 2005
- conference location
- Cracow, Poland
- conference dates
- 2005-09-11 - 2005-09-14
- external identifiers
-
- pmid:16307851
- wos:000236160300008
- scopus:32644444111
- ISSN
- 0378-4274
- DOI
- 10.1016/j.toxlet.2005.10.013
- language
- English
- LU publication?
- yes
- id
- ed09354f-1e8d-4290-8009-9484b910ea39 (old id 415270)
- date added to LUP
- 2016-04-01 16:42:08
- date last changed
- 2022-01-28 21:28:41
@inproceedings{ed09354f-1e8d-4290-8009-9484b910ea39,
abstract = {{Dendritic cells (DCs) play a crucial role in the sensitisation process. Upon encounter with an allergen, DCs require interactions with other cells and factors for triggering a primary or secondary immune response. Epithelial cells (ECs) express features of accessory cells, Such as expression of HLA-DR, co-stimulatory molecules, functional Fc gamma R, molecules of the antigen-processing machinery, and display an ability to internalise antigen. These features may authorize them to function as immunomodulators (e.g. amplification of memory T cells during secondary immune responses). ECs may increase chemokine (e.g. CCL20) secretion thereby attracting DCs. Epithelial human TSLP activates DC, which allow them to prime naive T cell, for the production of pro-inflammatory cytokines, while down-regulating IFN-gamma and IL-10. ECs may also influence the local polarization of types 1 and 2 antigen-presenting cells via PGE(2) by impairing the ability of maturing DC to produce bioactive IL-12 p70. PGE(2) is synergistic with IL-1 beta and TNF-alpha in the induction of functional and phenotypic maturation of DC and induce IL12 p40 production. Sensitisation via the respiratory route may be Th-2 skewed, possibly because the antigen recognition by DC occurs in an environment rich of airway EC-product such its PGE(2). (c) 2005 Elsevier Ireland Ltd. All rights reserved.}},
author = {{Roggen, EL and Lindstedt, Malin and Borrebaeck, Carl and Verheyen, GR}},
booktitle = {{Proceedings of the 42nd Congress of the European Societies of Toxicology - EUROTOX 2005 (Toxicology Letters)}},
issn = {{0378-4274}},
keywords = {{dendric cells sensitisation; immunomodulation; allergic disease; immune response}},
language = {{eng}},
number = {{1}},
pages = {{71--82}},
publisher = {{Elsevier}},
title = {{Interactions between dendritic cells and epithelial cells in allergic disease}},
url = {{http://dx.doi.org/10.1016/j.toxlet.2005.10.013}},
doi = {{10.1016/j.toxlet.2005.10.013}},
volume = {{162}},
year = {{2006}},
}