Polymorphisms in Genes Encoding Potential Mercury Transporters and Urine Mercury Concentrations in Populations Exposed to Mercury Vapor from Gold Mining.
Engström, Karin LU ; Ameer, Shegufta LU ; Bernaudat, Ludovic ; Drasch, Gustav ; Baeuml, Jennifer ; Skerfving, Staffan LU ; Bose-O'Reilly, Stephan and Broberg Palmgren, Karin LU
(2013)
In Environmental Health Perspectives
121(1).
p.85-91
- Abstract
- Background: Elemental mercury (Hg0) is widely used in small-scale gold mining. Individuals working or living in mining areas have high urinary concentrations of Hg (U-Hg). Differences in genes encoding potential Hg-transporters may affect uptake and elimination of Hg. Objective: To identify single nucleotide polymorphisms (SNPs) in Hg-transporter genes that modify U-Hg. Methods: 1,017 men and women from Indonesia, the Philippines, Tanzania, and Zimbabwe were classified either as controls (no Hg exposure from gold mining) or as having low (living in a gold-mining area) or high exposure (working as gold miners). U-Hg was analyzed by cold-vapor atomic absorption spectrometry. Eighteen SNPs in eight Hg-transporter genes were analyzed. Results:... (More)
- Background: Elemental mercury (Hg0) is widely used in small-scale gold mining. Individuals working or living in mining areas have high urinary concentrations of Hg (U-Hg). Differences in genes encoding potential Hg-transporters may affect uptake and elimination of Hg. Objective: To identify single nucleotide polymorphisms (SNPs) in Hg-transporter genes that modify U-Hg. Methods: 1,017 men and women from Indonesia, the Philippines, Tanzania, and Zimbabwe were classified either as controls (no Hg exposure from gold mining) or as having low (living in a gold-mining area) or high exposure (working as gold miners). U-Hg was analyzed by cold-vapor atomic absorption spectrometry. Eighteen SNPs in eight Hg-transporter genes were analyzed. Results: U-Hg concentrations were higher among ABCC2/MRP2 rs1885301 A-allele carriers than among GG homozygotes in all populations, though differences were not statistically significant in most cases. MRP2 SNPs showed particularly strong associations with U-Hg in the subgroup with highest exposure (miners in Zimbabwe) where rs1885301 A-allele carriers had higher U-Hg than GG homozygotes (geometric mean (GM): 36.4 µg/g creatinine vs. 21.9; p=0.027), rs2273697 GG homozygotes had higher U-Hg than A-allele carriers (GM: 37.4 vs. 16.7; p=0.001), and rs717620 A-allele carriers had higher U-Hg than GG homozygotes (GM: 83 vs. 28; p=0.084). The SLC7A5/LAT1 rs33916661 GG genotype was associated with higher U-Hg in all populations (statistically significant for all Tanzanians combined). SNPs in SLC22A6/OAT1 (rs4149170) and SLC22A8/OAT3 (rs4149182) were associated with U-Hg mainly in the Tanzanian study groups. Conclusions: SNPs in putative Hg-transporter genes may influence U-Hg concentrations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3160888
- author
- Engström, Karin
LU
; Ameer, Shegufta
LU
; Bernaudat, Ludovic
; Drasch, Gustav
; Baeuml, Jennifer
; Skerfving, Staffan
LU
; Bose-O'Reilly, Stephan
and Broberg Palmgren, Karin
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Environmental Health Perspectives
- volume
- 121
- issue
- 1
- pages
- 85 - 91
- publisher
- National Institute of Environmental Health Sciences
- external identifiers
-
- wos:000323698700029
- pmid:23052037
- scopus:84872064733
- pmid:23052037
- ISSN
- 1552-9924
- DOI
- 10.1289/ehp.1204951
- language
- English
- LU publication?
- yes
- id
- 4152954f-04e8-4bf4-aa29-685ec85d487f (old id 3160888)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23052037?dopt=Abstract
- date added to LUP
- 2016-04-01 10:19:42
- date last changed
- 2022-01-25 22:07:32
@article{4152954f-04e8-4bf4-aa29-685ec85d487f,
abstract = {{Background: Elemental mercury (Hg0) is widely used in small-scale gold mining. Individuals working or living in mining areas have high urinary concentrations of Hg (U-Hg). Differences in genes encoding potential Hg-transporters may affect uptake and elimination of Hg. Objective: To identify single nucleotide polymorphisms (SNPs) in Hg-transporter genes that modify U-Hg. Methods: 1,017 men and women from Indonesia, the Philippines, Tanzania, and Zimbabwe were classified either as controls (no Hg exposure from gold mining) or as having low (living in a gold-mining area) or high exposure (working as gold miners). U-Hg was analyzed by cold-vapor atomic absorption spectrometry. Eighteen SNPs in eight Hg-transporter genes were analyzed. Results: U-Hg concentrations were higher among ABCC2/MRP2 rs1885301 A-allele carriers than among GG homozygotes in all populations, though differences were not statistically significant in most cases. MRP2 SNPs showed particularly strong associations with U-Hg in the subgroup with highest exposure (miners in Zimbabwe) where rs1885301 A-allele carriers had higher U-Hg than GG homozygotes (geometric mean (GM): 36.4 µg/g creatinine vs. 21.9; p=0.027), rs2273697 GG homozygotes had higher U-Hg than A-allele carriers (GM: 37.4 vs. 16.7; p=0.001), and rs717620 A-allele carriers had higher U-Hg than GG homozygotes (GM: 83 vs. 28; p=0.084). The SLC7A5/LAT1 rs33916661 GG genotype was associated with higher U-Hg in all populations (statistically significant for all Tanzanians combined). SNPs in SLC22A6/OAT1 (rs4149170) and SLC22A8/OAT3 (rs4149182) were associated with U-Hg mainly in the Tanzanian study groups. Conclusions: SNPs in putative Hg-transporter genes may influence U-Hg concentrations.}},
author = {{Engström, Karin and Ameer, Shegufta and Bernaudat, Ludovic and Drasch, Gustav and Baeuml, Jennifer and Skerfving, Staffan and Bose-O'Reilly, Stephan and Broberg Palmgren, Karin}},
issn = {{1552-9924}},
language = {{eng}},
number = {{1}},
pages = {{85--91}},
publisher = {{National Institute of Environmental Health Sciences}},
series = {{Environmental Health Perspectives}},
title = {{Polymorphisms in Genes Encoding Potential Mercury Transporters and Urine Mercury Concentrations in Populations Exposed to Mercury Vapor from Gold Mining.}},
url = {{https://lup.lub.lu.se/search/files/1751599/3165448.pdf}},
doi = {{10.1289/ehp.1204951}},
volume = {{121}},
year = {{2013}},
}