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Trophoblast invasion : Tuning through LIF, signalling via Stat3

Poehlmann, Tobias G.; Fitzgerald, Justine S.; Meissner, Anja LU ; Wengenmayer, Tobias; Schleussner, Ekkehard; Friedrich, Karlheinz and Markert, Udo R. (2005) In Placenta 26(SUPPL.). p.37-41
Abstract

Aberrant activity of the signal transducer and activator of transcription 3 (Stat3) is believed to be essential for neoplastic cell behaviour and thus for the malignancy of tumor cells [Bowman T, Garcia R, Turkson J, Jove R. STATs in oncogenesis. Oncogene 2000;19:2474-88]. Extravillous trophoblast cells resemble malignancies in their invasive and destructive features, excluding the fact of sequential restriction to the first trimester of pregnancy. Trophoblast cells from term placentas have reduced invasive capacity [Hohn HP, Denker HW. Experimental modulation of cell-cell adhesion, invasiveness and differentiation in trophoblast cells. Cells Tissues Organs 2002;172:218-36]. Constitutively activated Stat3 DNA-binding activity in... (More)

Aberrant activity of the signal transducer and activator of transcription 3 (Stat3) is believed to be essential for neoplastic cell behaviour and thus for the malignancy of tumor cells [Bowman T, Garcia R, Turkson J, Jove R. STATs in oncogenesis. Oncogene 2000;19:2474-88]. Extravillous trophoblast cells resemble malignancies in their invasive and destructive features, excluding the fact of sequential restriction to the first trimester of pregnancy. Trophoblast cells from term placentas have reduced invasive capacity [Hohn HP, Denker HW. Experimental modulation of cell-cell adhesion, invasiveness and differentiation in trophoblast cells. Cells Tissues Organs 2002;172:218-36]. Constitutively activated Stat3 DNA-binding activity in choriocarcinoma cells, carcinomatous derivates of trophoblast cells, have been reported to correlate with its invasiveness [Corvinus FM, Fitzgerald JS, Friedrich K, Markert UR. Evidence for a correlation between trophoblast invasiveness and STAT3 activity. Am J Reprod Immunol 2003;50:316-21]. Here we demonstrate using RNAi that Stat3 activation is necessary in the invasive phenotype of trophoblast cells and can be controlled via Leukemia Inhibitory Factor (LIF). LIF provides a soluble extracellular signal that stimulates invasion in trophoblast and Jeg-3 choriocarcinoma cells. Loss of LIF-mediated invasion in these cells subsequent to STAT3 knock-down strongly suggests that STAT3 plays a crucial role in mediating this invasion.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Choriocarcinoma, Decidua, Invasion, LIF, Placenta, Pregnancy, STAT3, Trophoblast
in
Placenta
volume
26
issue
SUPPL.
pages
37 - 41
publisher
W B Saunders
external identifiers
  • scopus:17044432247
ISSN
0143-4004
DOI
10.1016/j.placenta.2005.01.007
language
English
LU publication?
no
id
415cb838-cb69-45dd-b9cd-15d0cb729351
date added to LUP
2017-05-23 22:27:37
date last changed
2017-11-12 04:32:14
@article{415cb838-cb69-45dd-b9cd-15d0cb729351,
  abstract     = {<p>Aberrant activity of the signal transducer and activator of transcription 3 (Stat3) is believed to be essential for neoplastic cell behaviour and thus for the malignancy of tumor cells [Bowman T, Garcia R, Turkson J, Jove R. STATs in oncogenesis. Oncogene 2000;19:2474-88]. Extravillous trophoblast cells resemble malignancies in their invasive and destructive features, excluding the fact of sequential restriction to the first trimester of pregnancy. Trophoblast cells from term placentas have reduced invasive capacity [Hohn HP, Denker HW. Experimental modulation of cell-cell adhesion, invasiveness and differentiation in trophoblast cells. Cells Tissues Organs 2002;172:218-36]. Constitutively activated Stat3 DNA-binding activity in choriocarcinoma cells, carcinomatous derivates of trophoblast cells, have been reported to correlate with its invasiveness [Corvinus FM, Fitzgerald JS, Friedrich K, Markert UR. Evidence for a correlation between trophoblast invasiveness and STAT3 activity. Am J Reprod Immunol 2003;50:316-21]. Here we demonstrate using RNAi that Stat3 activation is necessary in the invasive phenotype of trophoblast cells and can be controlled via Leukemia Inhibitory Factor (LIF). LIF provides a soluble extracellular signal that stimulates invasion in trophoblast and Jeg-3 choriocarcinoma cells. Loss of LIF-mediated invasion in these cells subsequent to STAT3 knock-down strongly suggests that STAT3 plays a crucial role in mediating this invasion.</p>},
  author       = {Poehlmann, Tobias G. and Fitzgerald, Justine S. and Meissner, Anja and Wengenmayer, Tobias and Schleussner, Ekkehard and Friedrich, Karlheinz and Markert, Udo R.},
  issn         = {0143-4004},
  keyword      = {Choriocarcinoma,Decidua,Invasion,LIF,Placenta,Pregnancy,STAT3,Trophoblast},
  language     = {eng},
  number       = {SUPPL.},
  pages        = {37--41},
  publisher    = {W B Saunders},
  series       = {Placenta},
  title        = {Trophoblast invasion : Tuning through LIF, signalling via Stat3},
  url          = {http://dx.doi.org/10.1016/j.placenta.2005.01.007},
  volume       = {26},
  year         = {2005},
}