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Contact sensitization to calocephalin, a sesquiterpene lactone of the guaianolide type from cushion bush (Leucophyta brownii, Compositae)

Paulsen, Evy ; Christensen, Lars P. ; Hindsén, Monica LU and Andersen, Klaus E. (2013) In Contact Dermatitis 69(5). p.303-310
Abstract
BackgroundCushion bush [Leucophyta brownii Cass.=Calocephalus brownii (Cass.) F. Muell.] is an Australian Compositae shrub that has been introduced into Scandinavia as a pot plant. The first case of sensitization occurred in a gardener, and the main allergen was identified as the guaianolide calocephalin. ObjectiveTo present the identification of the main allergen, and to assess the prevalence of sensitization to calocephalin in Compositae-allergic patients. Materials and methodsCalocephalin was isolated from a dichloromethane extract of aerial parts of cushion bush. Calocephalin 0.1% ethanol was included in the plant series in Malmo, Sweden, and Odense, Denmark. ResultsNuclear magnetic resonance (NMR) analysis of calocephalin resulted in... (More)
BackgroundCushion bush [Leucophyta brownii Cass.=Calocephalus brownii (Cass.) F. Muell.] is an Australian Compositae shrub that has been introduced into Scandinavia as a pot plant. The first case of sensitization occurred in a gardener, and the main allergen was identified as the guaianolide calocephalin. ObjectiveTo present the identification of the main allergen, and to assess the prevalence of sensitization to calocephalin in Compositae-allergic patients. Materials and methodsCalocephalin was isolated from a dichloromethane extract of aerial parts of cushion bush. Calocephalin 0.1% ethanol was included in the plant series in Malmo, Sweden, and Odense, Denmark. ResultsNuclear magnetic resonance (NMR) analysis of calocephalin resulted in a revision of its chemical structure to 4-acetoxy-1,2-epoxy-5,10H-guai-11(13)-en-12,8-olide. The prevalence of patch test positivity was up to 28% in aimed patch testing. Despite strongly positive patch test reactions, the relevance was unknown in the majority of cases, and only 1 person was occupationally sensitized. ConclusionCalocephalin is a potent contact allergen, but, as cushion bush is a low-maintenance pot plant, primary sensitization is most likely to occur through occupational exposure. Positive reactions in Compositae-sensitive persons probably occur because of cross-reactivity, and patients should be warned about contact with cushion bush plants. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, calocephalin, Calocephalus brownii, guaianolides, Leucophyta brownii, occupational, patch testing, sesquiterpene lactones
in
Contact Dermatitis
volume
69
issue
5
pages
303 - 310
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000325622400008
  • scopus:84885953836
  • pmid:23808909
ISSN
0105-1873
DOI
10.1111/cod.12096
language
English
LU publication?
yes
id
3734476c-bba0-43b1-80d5-c50304ebf960 (old id 4160245)
date added to LUP
2016-04-01 11:16:35
date last changed
2020-08-12 03:02:04
@article{3734476c-bba0-43b1-80d5-c50304ebf960,
  abstract     = {BackgroundCushion bush [Leucophyta brownii Cass.=Calocephalus brownii (Cass.) F. Muell.] is an Australian Compositae shrub that has been introduced into Scandinavia as a pot plant. The first case of sensitization occurred in a gardener, and the main allergen was identified as the guaianolide calocephalin. ObjectiveTo present the identification of the main allergen, and to assess the prevalence of sensitization to calocephalin in Compositae-allergic patients. Materials and methodsCalocephalin was isolated from a dichloromethane extract of aerial parts of cushion bush. Calocephalin 0.1% ethanol was included in the plant series in Malmo, Sweden, and Odense, Denmark. ResultsNuclear magnetic resonance (NMR) analysis of calocephalin resulted in a revision of its chemical structure to 4-acetoxy-1,2-epoxy-5,10H-guai-11(13)-en-12,8-olide. The prevalence of patch test positivity was up to 28% in aimed patch testing. Despite strongly positive patch test reactions, the relevance was unknown in the majority of cases, and only 1 person was occupationally sensitized. ConclusionCalocephalin is a potent contact allergen, but, as cushion bush is a low-maintenance pot plant, primary sensitization is most likely to occur through occupational exposure. Positive reactions in Compositae-sensitive persons probably occur because of cross-reactivity, and patients should be warned about contact with cushion bush plants.},
  author       = {Paulsen, Evy and Christensen, Lars P. and Hindsén, Monica and Andersen, Klaus E.},
  issn         = {0105-1873},
  language     = {eng},
  number       = {5},
  pages        = {303--310},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Contact sensitization to calocephalin, a sesquiterpene lactone of the guaianolide type from cushion bush (Leucophyta brownii, Compositae)},
  url          = {http://dx.doi.org/10.1111/cod.12096},
  doi          = {10.1111/cod.12096},
  volume       = {69},
  year         = {2013},
}