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The role of cystatin C in cerebral amyloid angiopathy and stroke: Cell biology and animal models : cell biology and animal models

Levy, Efrat ; Jaskolski, Mariusz and Grubb, Anders LU (2006) In Brain Pathology 16(1). p.60-70
Abstract

A variant of the cysteine protease inhibitor, cystatin C, forms amyloid deposited in the cerebral vasculature of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type (HCHWA-I), leading to cerebral hemorrhages early in life. However, cystatin C is also implicated in neuronal degenerative diseases in which it does not form the amyloid protein, such as Alzheimer disease (AD). Accumulating data suggest involvement of cystatin C in the pathogenic processes leading to amyloid deposition in cerebral vasculature and most significantly to cerebral hemorrhage in patients with cerebral amyloid angiopathy (CAA). This review focuses on cell culture and animal models used to study the role of cystatin C in these processes.

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; and
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type
Contribution to journal
publication status
published
subject
keywords
Alzheimer Disease, Animals, Cerebral Amyloid Angiopathy, Cystatin C, Cystatins, Disease Models, Animal, Humans, Neurofibrils, Stroke, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
in
Brain Pathology
volume
16
issue
1
pages
11 pages
publisher
Wiley-Blackwell
external identifiers
  • wos:000235963200008
  • pmid:16612983
  • scopus:33646576172
  • pmid:16612983
ISSN
1750-3639
DOI
10.1111/j.1750-3639.2006.tb00562.x
language
English
LU publication?
yes
id
fc1f483f-3f9c-4f8e-b235-b39a0431e19c (old id 416546)
date added to LUP
2016-04-01 15:56:48
date last changed
2020-11-10 05:38:41
@article{fc1f483f-3f9c-4f8e-b235-b39a0431e19c,
  abstract     = {<p>A variant of the cysteine protease inhibitor, cystatin C, forms amyloid deposited in the cerebral vasculature of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type (HCHWA-I), leading to cerebral hemorrhages early in life. However, cystatin C is also implicated in neuronal degenerative diseases in which it does not form the amyloid protein, such as Alzheimer disease (AD). Accumulating data suggest involvement of cystatin C in the pathogenic processes leading to amyloid deposition in cerebral vasculature and most significantly to cerebral hemorrhage in patients with cerebral amyloid angiopathy (CAA). This review focuses on cell culture and animal models used to study the role of cystatin C in these processes.</p>},
  author       = {Levy, Efrat and Jaskolski, Mariusz and Grubb, Anders},
  issn         = {1750-3639},
  language     = {eng},
  number       = {1},
  pages        = {60--70},
  publisher    = {Wiley-Blackwell},
  series       = {Brain Pathology},
  title        = {The role of cystatin C in cerebral amyloid angiopathy and stroke: Cell biology and animal models : cell biology and animal models},
  url          = {http://dx.doi.org/10.1111/j.1750-3639.2006.tb00562.x},
  doi          = {10.1111/j.1750-3639.2006.tb00562.x},
  volume       = {16},
  year         = {2006},
}