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Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitis

Benigni, F ; Baroni, E ; Zecevic, M ; Zvara, P ; Streng, Tomi LU ; Hedlund, Petter LU ; Colli, E ; D'Ambrosio, D and Andersson, Karl-Erik LU orcid (2006) In BJU International 97(3). p.617-624
Abstract
To investigate the effects of a vitamin D3 analogue (BXL628) in a model of chronic cystitis, as calcitriol analogues might be an interesting new therapeutic option for interstitial cystitis, for although the cause of the disease remains unclear, the increase in mast cells in the mucosa and detrusor muscle are significant. We devised a mouse model of allergen-induced allergic cystitis that is associated with the up-regulation of genes for interleukin-13, Fc epsilon RI alpha and mast cells-derived proteases, a massive inflammatory reaction in the bladder tissue, and augmented levels of mast cell-derived protease 1 (MMCP1) detected in mouse sera. Oral administration of BXL628 significantly reduced the expression of interleukin-13, Fc epsilon... (More)
To investigate the effects of a vitamin D3 analogue (BXL628) in a model of chronic cystitis, as calcitriol analogues might be an interesting new therapeutic option for interstitial cystitis, for although the cause of the disease remains unclear, the increase in mast cells in the mucosa and detrusor muscle are significant. We devised a mouse model of allergen-induced allergic cystitis that is associated with the up-regulation of genes for interleukin-13, Fc epsilon RI alpha and mast cells-derived proteases, a massive inflammatory reaction in the bladder tissue, and augmented levels of mast cell-derived protease 1 (MMCP1) detected in mouse sera. Oral administration of BXL628 significantly reduced the expression of interleukin-13, Fc epsilon RI alpha and MMCP1 in the bladder. Furthermore, histological analysis showed a decrease in oedema and leukocyte infiltration in the bladder wall. BXL628 treatment reduced serum MMCP1 levels, indicating an effect on mast cell degranulation in vivo. Vitamin D3 analogues may successfully be used as anti-inflammatory agents in allergen-mediated inflammatory reactions. Moreover, the modulatory effect shown on mast cell activation by the BXL628 analogue strongly supports its potential therapeutic use in a possibly mast cell-dependent disease such as human interstitial cystitis. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antigen-induced cystitis, mast cells, mouse, anti-inflammatory effect, interstitial cystitis, vitamin D3 analogue
in
BJU International
volume
97
issue
3
pages
617 - 624
publisher
Wiley-Blackwell
external identifiers
  • wos:000235255600038
  • pmid:16469037
  • scopus:33645000397
  • pmid:16469037
ISSN
1464-4096
DOI
10.1111/j.1464-410X.2006.05971.x
language
English
LU publication?
yes
id
bbac031c-4cb9-4e20-a50a-5d45c859546a (old id 416566)
date added to LUP
2016-04-01 12:23:39
date last changed
2021-02-17 03:21:24
@article{bbac031c-4cb9-4e20-a50a-5d45c859546a,
  abstract     = {To investigate the effects of a vitamin D3 analogue (BXL628) in a model of chronic cystitis, as calcitriol analogues might be an interesting new therapeutic option for interstitial cystitis, for although the cause of the disease remains unclear, the increase in mast cells in the mucosa and detrusor muscle are significant. We devised a mouse model of allergen-induced allergic cystitis that is associated with the up-regulation of genes for interleukin-13, Fc epsilon RI alpha and mast cells-derived proteases, a massive inflammatory reaction in the bladder tissue, and augmented levels of mast cell-derived protease 1 (MMCP1) detected in mouse sera. Oral administration of BXL628 significantly reduced the expression of interleukin-13, Fc epsilon RI alpha and MMCP1 in the bladder. Furthermore, histological analysis showed a decrease in oedema and leukocyte infiltration in the bladder wall. BXL628 treatment reduced serum MMCP1 levels, indicating an effect on mast cell degranulation in vivo. Vitamin D3 analogues may successfully be used as anti-inflammatory agents in allergen-mediated inflammatory reactions. Moreover, the modulatory effect shown on mast cell activation by the BXL628 analogue strongly supports its potential therapeutic use in a possibly mast cell-dependent disease such as human interstitial cystitis.},
  author       = {Benigni, F and Baroni, E and Zecevic, M and Zvara, P and Streng, Tomi and Hedlund, Petter and Colli, E and D'Ambrosio, D and Andersson, Karl-Erik},
  issn         = {1464-4096},
  language     = {eng},
  number       = {3},
  pages        = {617--624},
  publisher    = {Wiley-Blackwell},
  series       = {BJU International},
  title        = {Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitis},
  url          = {http://dx.doi.org/10.1111/j.1464-410X.2006.05971.x},
  doi          = {10.1111/j.1464-410X.2006.05971.x},
  volume       = {97},
  year         = {2006},
}