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Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

Piacham, Theeraphon LU ; Isarankura-Na-Ayuldhya, C ; Nantasenamat, C ; Yainoy, S ; Ye, Lei LU orcid ; Bülow, Leif LU and Prachayasittikul, V (2006) In Biochemical and Biophysical Research Communications 341(4). p.925-930
Abstract
Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of... (More)
Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
molecular, modeling, SOD mimic, SOD, superoxide dismutase, antibiotic, bacitracin
in
Biochemical and Biophysical Research Communications
volume
341
issue
4
pages
925 - 930
publisher
Elsevier
external identifiers
  • wos:000235699900005
  • pmid:16455051
  • scopus:32344435147
  • pmid:16455051
ISSN
1090-2104
DOI
10.1016/j.bbrc.2006.01.045
language
English
LU publication?
yes
id
ef71350b-48bd-4d5a-94f0-9843dfceccff (old id 416903)
date added to LUP
2016-04-01 16:45:28
date last changed
2021-09-29 02:30:38
@article{ef71350b-48bd-4d5a-94f0-9843dfceccff,
  abstract     = {Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.},
  author       = {Piacham, Theeraphon and Isarankura-Na-Ayuldhya, C and Nantasenamat, C and Yainoy, S and Ye, Lei and Bülow, Leif and Prachayasittikul, V},
  issn         = {1090-2104},
  language     = {eng},
  number       = {4},
  pages        = {925--930},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2006.01.045},
  doi          = {10.1016/j.bbrc.2006.01.045},
  volume       = {341},
  year         = {2006},
}