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The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment

Lewis, Sheena E. M. ; Aitken, R. John ; Conner, Sarah J. ; De Iuliis, Geoffry ; Evenson, Donald P. ; Henkel, Ralph ; Giwercman, Aleksander LU and Gharagozloo, Parviz (2013) In Reproductive BioMedicine Online 27(4). p.325-337
Abstract
Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in the field of sperm DNA damage in the clinical setting. It explores current laboratory tests and the accumulating body of knowledge concerning the relationship between sperm DNA damage and clinical outcomes. The paper proceeds to discuss the strengths, weaknesses and clinical applicability of current sperm DNA tests. Next, the biological... (More)
Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in the field of sperm DNA damage in the clinical setting. It explores current laboratory tests and the accumulating body of knowledge concerning the relationship between sperm DNA damage and clinical outcomes. The paper proceeds to discuss the strengths, weaknesses and clinical applicability of current sperm DNA tests. Next, the biological significance of DNA damage in the male germ line is considered. Finally, as sperm DNA damage is often the result of oxidative stress in the male reproductive tract, the potential contribution of antioxidant therapy in the clinical management of this condition is discussed. DNA damage in human spermatozoa is an important attribute of semen quality. It should be part of the clinical work up and properly controlled trials addressing the effectiveness of antioxidant therapy should be undertaken as a matter of urgency. (c) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antioxidant therapy, assisted reproduction, DNA fragmentation, Male, infertility, oxidized bases, spermatozoa
in
Reproductive BioMedicine Online
volume
27
issue
4
pages
325 - 337
publisher
Reproductive Healthcare Ltd
external identifiers
  • wos:000325098200002
  • scopus:84885191376
ISSN
1472-6491
DOI
10.1016/j.rbmo.2013.06.014
language
English
LU publication?
yes
id
3bab81fa-e5d2-4c0a-8756-e1c9ffcb77c3 (old id 4172125)
date added to LUP
2016-04-01 10:56:49
date last changed
2020-09-23 02:17:45
@article{3bab81fa-e5d2-4c0a-8756-e1c9ffcb77c3,
  abstract     = {Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in the field of sperm DNA damage in the clinical setting. It explores current laboratory tests and the accumulating body of knowledge concerning the relationship between sperm DNA damage and clinical outcomes. The paper proceeds to discuss the strengths, weaknesses and clinical applicability of current sperm DNA tests. Next, the biological significance of DNA damage in the male germ line is considered. Finally, as sperm DNA damage is often the result of oxidative stress in the male reproductive tract, the potential contribution of antioxidant therapy in the clinical management of this condition is discussed. DNA damage in human spermatozoa is an important attribute of semen quality. It should be part of the clinical work up and properly controlled trials addressing the effectiveness of antioxidant therapy should be undertaken as a matter of urgency. (c) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.},
  author       = {Lewis, Sheena E. M. and Aitken, R. John and Conner, Sarah J. and De Iuliis, Geoffry and Evenson, Donald P. and Henkel, Ralph and Giwercman, Aleksander and Gharagozloo, Parviz},
  issn         = {1472-6491},
  language     = {eng},
  number       = {4},
  pages        = {325--337},
  publisher    = {Reproductive Healthcare Ltd},
  series       = {Reproductive BioMedicine Online},
  title        = {The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment},
  url          = {http://dx.doi.org/10.1016/j.rbmo.2013.06.014},
  doi          = {10.1016/j.rbmo.2013.06.014},
  volume       = {27},
  year         = {2013},
}