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Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.

Dahlberg, Jonas LU ; Sjögren, Marketa LU ; Hedblad, Bo LU ; Engström, Gunnar LU and Melander, Olle LU (2014) In Journal of Hypertension 32(2). p.294-299
Abstract
We have previously shown that genetic variance in NEDD4L, a regulating protein of a sodium channel in the distal nephron, has been associated with marginally higher blood pressure and enhanced salt sensitivity. Here, we tested if the genetic NEDD4L variation previously associated with salt sensitivity is related to population blood pressure, incidence of cardiovascular disease (CVD) and mortality.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
32
issue
2
pages
294 - 299
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:24284497
  • wos:000330876000014
  • scopus:84892959334
ISSN
1473-5598
DOI
10.1097/HJH.0000000000000044
language
English
LU publication?
yes
id
729d9598-f06d-4501-ad09-842b1b31b45d (old id 4178856)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24284497?dopt=Abstract
date added to LUP
2013-12-02 18:35:43
date last changed
2017-07-02 03:04:03
@article{729d9598-f06d-4501-ad09-842b1b31b45d,
  abstract     = {We have previously shown that genetic variance in NEDD4L, a regulating protein of a sodium channel in the distal nephron, has been associated with marginally higher blood pressure and enhanced salt sensitivity. Here, we tested if the genetic NEDD4L variation previously associated with salt sensitivity is related to population blood pressure, incidence of cardiovascular disease (CVD) and mortality.},
  author       = {Dahlberg, Jonas and Sjögren, Marketa and Hedblad, Bo and Engström, Gunnar and Melander, Olle},
  issn         = {1473-5598},
  language     = {eng},
  number       = {2},
  pages        = {294--299},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.},
  url          = {http://dx.doi.org/10.1097/HJH.0000000000000044},
  volume       = {32},
  year         = {2014},
}