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Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.

Mahmutovic Persson, Irma LU ; Akbarshahi, Hamid LU ; Bartlett, N W; Glanville, N; Johnston, S L; Brandelius, Angelica LU and Uller, Lena LU (2014) In Allergy 69(3). p.348-358
Abstract
Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Allergy
volume
69
issue
3
pages
348 - 358
publisher
Wiley-Blackwell
external identifiers
  • pmid:24283976
  • wos:000331358400008
  • scopus:84894267969
ISSN
1398-9995
DOI
10.1111/all.12329
language
English
LU publication?
yes
id
ae2164bf-c191-4267-a6bb-5898e6bcc015 (old id 4178864)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24283976?dopt=Abstract
date added to LUP
2013-12-02 18:42:52
date last changed
2017-08-06 03:21:37
@article{ae2164bf-c191-4267-a6bb-5898e6bcc015,
  abstract     = {Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.},
  author       = {Mahmutovic Persson, Irma and Akbarshahi, Hamid and Bartlett, N W and Glanville, N and Johnston, S L and Brandelius, Angelica and Uller, Lena},
  issn         = {1398-9995},
  language     = {eng},
  number       = {3},
  pages        = {348--358},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy},
  title        = {Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.},
  url          = {http://dx.doi.org/10.1111/all.12329},
  volume       = {69},
  year         = {2014},
}