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Human foetal brain tissue as quality control when developing stem cells towards cell replacement therapy for neurological diseases.

Nelander Wahlestedt, Jenny LU ; Grealish, Shane LU and Parmar, Malin LU (2013) In NeuroReport 24(18). p.1025-1030
Abstract
Human foetal brain tissue has been used in experimental and clinical trials to develop cell replacement therapy in neurodegenerative disorders such as Parkinson's disease and Huntington's disease. These pioneering clinical studies have shown proof of principle that cell replacement therapy can be effective and is worthwhile to develop as a therapeutic strategy for repairing the damaged brain. However, because of the limited availability of foetal brain material, and difficulties in producing standardized and quality-tested cell preparations from this source, there have been extensive efforts in investigating the potential use of alternative cell sources for generating a large number of transplantable, authentic neural progenitors and... (More)
Human foetal brain tissue has been used in experimental and clinical trials to develop cell replacement therapy in neurodegenerative disorders such as Parkinson's disease and Huntington's disease. These pioneering clinical studies have shown proof of principle that cell replacement therapy can be effective and is worthwhile to develop as a therapeutic strategy for repairing the damaged brain. However, because of the limited availability of foetal brain material, and difficulties in producing standardized and quality-tested cell preparations from this source, there have been extensive efforts in investigating the potential use of alternative cell sources for generating a large number of transplantable, authentic neural progenitors and neurons. In this review, we highlight the value of using human foetal tissue as a reference material for quality control of acquired cell fate of in vitro generated neurons before and after transplantation. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
24
issue
18
pages
1025 - 1030
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:24257249
  • wos:000330375600007
  • scopus:84889254011
  • pmid:24257249
ISSN
1473-558X
DOI
10.1097/WNR.0000000000000058
language
English
LU publication?
yes
id
5deafb8e-5fef-4b3b-9966-0d185201735c (old id 4179093)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24257249?dopt=Abstract
date added to LUP
2016-04-01 10:25:01
date last changed
2020-01-12 03:35:55
@article{5deafb8e-5fef-4b3b-9966-0d185201735c,
  abstract     = {Human foetal brain tissue has been used in experimental and clinical trials to develop cell replacement therapy in neurodegenerative disorders such as Parkinson's disease and Huntington's disease. These pioneering clinical studies have shown proof of principle that cell replacement therapy can be effective and is worthwhile to develop as a therapeutic strategy for repairing the damaged brain. However, because of the limited availability of foetal brain material, and difficulties in producing standardized and quality-tested cell preparations from this source, there have been extensive efforts in investigating the potential use of alternative cell sources for generating a large number of transplantable, authentic neural progenitors and neurons. In this review, we highlight the value of using human foetal tissue as a reference material for quality control of acquired cell fate of in vitro generated neurons before and after transplantation.},
  author       = {Nelander Wahlestedt, Jenny and Grealish, Shane and Parmar, Malin},
  issn         = {1473-558X},
  language     = {eng},
  number       = {18},
  pages        = {1025--1030},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Human foetal brain tissue as quality control when developing stem cells towards cell replacement therapy for neurological diseases.},
  url          = {https://lup.lub.lu.se/search/ws/files/1826665/4187064.pdf},
  doi          = {10.1097/WNR.0000000000000058},
  volume       = {24},
  year         = {2013},
}