To harm or not to harm? On the evolution and expression of virulence in group A streptococci.
(2014) In Trends in Microbiology 22(1). p.7-13- Abstract
- Group A streptococci (GAS) cause three different types of infection (sensu lato) with distinct levels of virulence: asymptomatic colonization, superficial symptomatic infection, and invasive infection. To address why this pattern with several infection types has evolved, we combine mechanistic understanding from infection medicine with recent theory from evolutionary ecology. We propose that asymptomatic colonization and superficial symptomatic infection exploit different states of the host epithelium to maximize transmission between hosts in different epidemiological conditions, whereas the ability of the bacteria to cause invasive infection is a non-adaptive side effect of traits required for superficial symptomatic infection.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4179283
- author
- Wollein Waldetoft, Kristofer LU and Råberg, Lars
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Streptococcus pyogenes, virulence, evolution, regulation, epigenetic, bistability
- in
- Trends in Microbiology
- volume
- 22
- issue
- 1
- pages
- 7 - 13
- publisher
- Elsevier
- external identifiers
-
- wos:000329773300004
- pmid:24238777
- scopus:84891372332
- pmid:24238777
- ISSN
- 1878-4380
- DOI
- 10.1016/j.tim.2013.10.006
- language
- English
- LU publication?
- yes
- additional info
- Accepted author's manuscript
- id
- 99f4e5ea-431f-44a9-97db-ae66e2d9e1ba (old id 4179283)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24238777?dopt=Abstract
- date added to LUP
- 2016-04-01 10:37:07
- date last changed
- 2022-01-26 00:56:25
@article{99f4e5ea-431f-44a9-97db-ae66e2d9e1ba,
abstract = {{Group A streptococci (GAS) cause three different types of infection (sensu lato) with distinct levels of virulence: asymptomatic colonization, superficial symptomatic infection, and invasive infection. To address why this pattern with several infection types has evolved, we combine mechanistic understanding from infection medicine with recent theory from evolutionary ecology. We propose that asymptomatic colonization and superficial symptomatic infection exploit different states of the host epithelium to maximize transmission between hosts in different epidemiological conditions, whereas the ability of the bacteria to cause invasive infection is a non-adaptive side effect of traits required for superficial symptomatic infection.}},
author = {{Wollein Waldetoft, Kristofer and Råberg, Lars}},
issn = {{1878-4380}},
keywords = {{Streptococcus pyogenes; virulence; evolution; regulation; epigenetic; bistability}},
language = {{eng}},
number = {{1}},
pages = {{7--13}},
publisher = {{Elsevier}},
series = {{Trends in Microbiology}},
title = {{To harm or not to harm? On the evolution and expression of virulence in group A streptococci.}},
url = {{https://lup.lub.lu.se/search/files/1995907/4251454.pdf}},
doi = {{10.1016/j.tim.2013.10.006}},
volume = {{22}},
year = {{2014}},
}