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To harm or not to harm? On the evolution and expression of virulence in group A streptococci.

Wollein Waldetoft, Kristofer LU and Råberg, Lars (2014) In Trends in Microbiology 22(1). p.7-13
Abstract
Group A streptococci (GAS) cause three different types of infection (sensu lato) with distinct levels of virulence: asymptomatic colonization, superficial symptomatic infection, and invasive infection. To address why this pattern with several infection types has evolved, we combine mechanistic understanding from infection medicine with recent theory from evolutionary ecology. We propose that asymptomatic colonization and superficial symptomatic infection exploit different states of the host epithelium to maximize transmission between hosts in different epidemiological conditions, whereas the ability of the bacteria to cause invasive infection is a non-adaptive side effect of traits required for superficial symptomatic infection.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Streptococcus pyogenes, virulence, evolution, regulation, epigenetic, bistability
in
Trends in Microbiology
volume
22
issue
1
pages
7 - 13
publisher
Elsevier
external identifiers
  • wos:000329773300004
  • pmid:24238777
  • scopus:84891372332
ISSN
1878-4380
DOI
10.1016/j.tim.2013.10.006
language
English
LU publication?
yes
id
99f4e5ea-431f-44a9-97db-ae66e2d9e1ba (old id 4179283)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24238777?dopt=Abstract
date added to LUP
2013-12-03 18:55:22
date last changed
2017-06-25 03:15:19
@article{99f4e5ea-431f-44a9-97db-ae66e2d9e1ba,
  abstract     = {Group A streptococci (GAS) cause three different types of infection (sensu lato) with distinct levels of virulence: asymptomatic colonization, superficial symptomatic infection, and invasive infection. To address why this pattern with several infection types has evolved, we combine mechanistic understanding from infection medicine with recent theory from evolutionary ecology. We propose that asymptomatic colonization and superficial symptomatic infection exploit different states of the host epithelium to maximize transmission between hosts in different epidemiological conditions, whereas the ability of the bacteria to cause invasive infection is a non-adaptive side effect of traits required for superficial symptomatic infection.},
  author       = {Wollein Waldetoft, Kristofer and Råberg, Lars},
  issn         = {1878-4380},
  keyword      = {Streptococcus pyogenes,virulence,evolution,regulation,epigenetic,bistability},
  language     = {eng},
  number       = {1},
  pages        = {7--13},
  publisher    = {Elsevier},
  series       = {Trends in Microbiology},
  title        = {To harm or not to harm? On the evolution and expression of virulence in group A streptococci.},
  url          = {http://dx.doi.org/10.1016/j.tim.2013.10.006},
  volume       = {22},
  year         = {2014},
}