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Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.

Bhattachariya, Anirban LU ; Dahan, Diana LU ; Turczynska, Karolina LU ; Swärd, Karl LU ; Hellstrand, Per LU and Albinsson, Sebastian LU (2014) In Cardiovascular Research 101(2). p.288-296
Abstract
The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have been shown to play a role in vascular smooth muscle function, their importance in the regulation of the myogenic response is not known. In this study, we investigate the role of microRNAs in the regulation of myogenic tone by using smooth muscle-specific and tamoxifen-inducible deletion of the endonuclease Dicer in mice.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cardiovascular Research
volume
101
issue
2
pages
288 - 296
publisher
Elsevier
external identifiers
  • pmid:24233972
  • wos:000330835300013
  • scopus:84893099457
ISSN
1755-3245
DOI
10.1093/cvr/cvt253
language
English
LU publication?
yes
id
4c59570a-4b3a-43f6-ad59-f6dac993c4eb (old id 4179332)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24233972?dopt=Abstract
date added to LUP
2013-12-06 14:57:10
date last changed
2017-10-22 03:26:31
@article{4c59570a-4b3a-43f6-ad59-f6dac993c4eb,
  abstract     = {The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have been shown to play a role in vascular smooth muscle function, their importance in the regulation of the myogenic response is not known. In this study, we investigate the role of microRNAs in the regulation of myogenic tone by using smooth muscle-specific and tamoxifen-inducible deletion of the endonuclease Dicer in mice.},
  author       = {Bhattachariya, Anirban and Dahan, Diana and Turczynska, Karolina and Swärd, Karl and Hellstrand, Per and Albinsson, Sebastian},
  issn         = {1755-3245},
  language     = {eng},
  number       = {2},
  pages        = {288--296},
  publisher    = {Elsevier},
  series       = {Cardiovascular Research},
  title        = {Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.},
  url          = {http://dx.doi.org/10.1093/cvr/cvt253},
  volume       = {101},
  year         = {2014},
}