Disease models of chronic inflammatory airway disease: applications and requirements for clinical trials.
(2014) In Current Opinion in Pulmonary Medicine 20(1). p.37-45- Abstract
- This review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development. Additionally, important regulatory aspects regarding noninvestigational medicinal products used in bronchial challenges or clinical inflammatory models of respiratory disease will be highlighted.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4179341
- author
- Diamant, Zuzana LU ; Clarke, Graham W ; Pieterse, Herman and Gispert, Juan
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Pulmonary Medicine
- volume
- 20
- issue
- 1
- pages
- 37 - 45
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000327671900006
- pmid:24231465
- scopus:84890129117
- pmid:24231465
- ISSN
- 1531-6971
- DOI
- 10.1097/MCP.0000000000000013
- language
- English
- LU publication?
- yes
- id
- 4aeaae27-9a20-454a-954e-15c08dca9a3d (old id 4179341)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24231465?dopt=Abstract
- date added to LUP
- 2016-04-01 10:52:34
- date last changed
- 2022-01-26 03:17:57
@article{4aeaae27-9a20-454a-954e-15c08dca9a3d,
abstract = {{This review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development. Additionally, important regulatory aspects regarding noninvestigational medicinal products used in bronchial challenges or clinical inflammatory models of respiratory disease will be highlighted.}},
author = {{Diamant, Zuzana and Clarke, Graham W and Pieterse, Herman and Gispert, Juan}},
issn = {{1531-6971}},
language = {{eng}},
number = {{1}},
pages = {{37--45}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Current Opinion in Pulmonary Medicine}},
title = {{Disease models of chronic inflammatory airway disease: applications and requirements for clinical trials.}},
url = {{http://dx.doi.org/10.1097/MCP.0000000000000013}},
doi = {{10.1097/MCP.0000000000000013}},
volume = {{20}},
year = {{2014}},
}