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Disease models of chronic inflammatory airway disease: applications and requirements for clinical trials.

Diamant, Zuzana LU ; Clarke, Graham W; Pieterse, Herman and Gispert, Juan (2014) In Current Opinion in Pulmonary Medicine 20(1). p.37-45
Abstract
This review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development. Additionally, important regulatory aspects regarding noninvestigational medicinal products used in bronchial challenges or clinical inflammatory models of respiratory disease will be highlighted.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Pulmonary Medicine
volume
20
issue
1
pages
37 - 45
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000327671900006
  • pmid:24231465
  • scopus:84890129117
ISSN
1531-6971
DOI
10.1097/MCP.0000000000000013
language
English
LU publication?
yes
id
4aeaae27-9a20-454a-954e-15c08dca9a3d (old id 4179341)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24231465?dopt=Abstract
date added to LUP
2013-12-06 15:11:55
date last changed
2017-01-01 03:58:25
@article{4aeaae27-9a20-454a-954e-15c08dca9a3d,
  abstract     = {This review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development. Additionally, important regulatory aspects regarding noninvestigational medicinal products used in bronchial challenges or clinical inflammatory models of respiratory disease will be highlighted.},
  author       = {Diamant, Zuzana and Clarke, Graham W and Pieterse, Herman and Gispert, Juan},
  issn         = {1531-6971},
  language     = {eng},
  number       = {1},
  pages        = {37--45},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Pulmonary Medicine},
  title        = {Disease models of chronic inflammatory airway disease: applications and requirements for clinical trials.},
  url          = {http://dx.doi.org/10.1097/MCP.0000000000000013},
  volume       = {20},
  year         = {2014},
}