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Functional outcome and health-related quality of life in patients with sacrococcygeal teratoma – a Swedish multicenter study

Hambraeus, Mette LU ; Al-Mashhadi, Ammar; Wester, Tomas; Svensson, Pär Johan; Stenström, Pernilla LU and Lilja, Helene Engstrand (2018) In Journal of Pediatric Surgery
Abstract

Background/Purpose: The aims of this study were to evaluate bowel and urinary tract function, to identify predictors for dysfunctional outcome and to evaluate health-related quality-of life (QoL) in patients treated for sacrococcygeal teratomas (SCT). Methods: Medical records of patients with SCT born between 1985 and 2015 treated at three Swedish pediatric surgical centers were reviewed. Questionnaires regarding urinary tract function, bowel function and QoL were sent to patients and parents. Different QoL instruments were used for the different age groups. Results: Totally 85 patients were identified. Four patients died in the neonatal period. Forty-nine patients answered the questionnaires (60%). Median age at follow-up was 8.9 years... (More)

Background/Purpose: The aims of this study were to evaluate bowel and urinary tract function, to identify predictors for dysfunctional outcome and to evaluate health-related quality-of life (QoL) in patients treated for sacrococcygeal teratomas (SCT). Methods: Medical records of patients with SCT born between 1985 and 2015 treated at three Swedish pediatric surgical centers were reviewed. Questionnaires regarding urinary tract function, bowel function and QoL were sent to patients and parents. Different QoL instruments were used for the different age groups. Results: Totally 85 patients were identified. Four patients died in the neonatal period. Forty-nine patients answered the questionnaires (60%). Median age at follow-up was 8.9 years (range 3.6–28.8). Bowel dysfunction was reported by 36% and urinary tract dysfunction by 46% of the patients. Univariate analysis revealed that urinary tract dysfunction correlated with gestational age (p = 0.018) and immature histology (p = 0.008), and bowel dysfunction correlated with gestational age (p = 0.016) and tumor size (p = 0.042). Low gestational age was an independent predictor for both urinary tract and bowel dysfunction. Good or very good QoL was reported by 56% of children aged 4–7 years, 90% of children aged 8–17 years and 67% of the adults. Conclusion: Although a considerable proportion of bowel and urinary tract dysfunction was found, the reported QoL was good in a majority of the patients with SCT. Low gestational age was found to be a predictor for bowel- and urinary tract dysfunction. Level of Evidence: Level III.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Outcome, Quality of life, Sacrococcygeal teratoma
in
Journal of Pediatric Surgery
publisher
Elsevier
external identifiers
  • scopus:85056278808
ISSN
0022-3468
DOI
10.1016/j.jpedsurg.2018.10.044
language
English
LU publication?
yes
id
417fb707-d82c-4c71-8351-3579fd31e093
date added to LUP
2018-11-23 09:36:41
date last changed
2019-02-20 11:37:24
@article{417fb707-d82c-4c71-8351-3579fd31e093,
  abstract     = {<p>Background/Purpose: The aims of this study were to evaluate bowel and urinary tract function, to identify predictors for dysfunctional outcome and to evaluate health-related quality-of life (QoL) in patients treated for sacrococcygeal teratomas (SCT). Methods: Medical records of patients with SCT born between 1985 and 2015 treated at three Swedish pediatric surgical centers were reviewed. Questionnaires regarding urinary tract function, bowel function and QoL were sent to patients and parents. Different QoL instruments were used for the different age groups. Results: Totally 85 patients were identified. Four patients died in the neonatal period. Forty-nine patients answered the questionnaires (60%). Median age at follow-up was 8.9 years (range 3.6–28.8). Bowel dysfunction was reported by 36% and urinary tract dysfunction by 46% of the patients. Univariate analysis revealed that urinary tract dysfunction correlated with gestational age (p = 0.018) and immature histology (p = 0.008), and bowel dysfunction correlated with gestational age (p = 0.016) and tumor size (p = 0.042). Low gestational age was an independent predictor for both urinary tract and bowel dysfunction. Good or very good QoL was reported by 56% of children aged 4–7 years, 90% of children aged 8–17 years and 67% of the adults. Conclusion: Although a considerable proportion of bowel and urinary tract dysfunction was found, the reported QoL was good in a majority of the patients with SCT. Low gestational age was found to be a predictor for bowel- and urinary tract dysfunction. Level of Evidence: Level III.</p>},
  author       = {Hambraeus, Mette and Al-Mashhadi, Ammar and Wester, Tomas and Svensson, Pär Johan and Stenström, Pernilla and Lilja, Helene Engstrand},
  issn         = {0022-3468},
  keyword      = {Outcome,Quality of life,Sacrococcygeal teratoma},
  language     = {eng},
  month        = {10},
  publisher    = {Elsevier},
  series       = {Journal of Pediatric Surgery},
  title        = {Functional outcome and health-related quality of life in patients with sacrococcygeal teratoma – a Swedish multicenter study},
  url          = {http://dx.doi.org/10.1016/j.jpedsurg.2018.10.044},
  year         = {2018},
}