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Plasma-lead concentration: investigations into its usefulness for biological monitoring of occupational lead exposure

Bergdahl, I A ; Gerhardsson, Lars LU ; Liljelind, IE ; Nilsson, L and Skerfving, Staffan LU (2006) In American Journal of Industrial Medicine 49(2). p.93-101
Abstract
Background The lead concentration in plasma is correlated to that in whole blood with a two to fourfold variation. It has never been investigated if this variation is interindividual. Methods Lead and hemoglobin were determined in blood and plasma from 13 lead workers with a history of relatively high blood-lead concentrations, sampled three times during 1 day. The variation in the distribution of lead between cells and plasma was studied, but not the variation in the lead concentrations as such. Results Blood hemoglobin decreased with rising plasma lead (0.9-3.0 mu g/L). Regarding the distribution of lead, no effect of current exposure during the day or of recent meals appeared. As much as 84% of the overall variance of the distribution... (More)
Background The lead concentration in plasma is correlated to that in whole blood with a two to fourfold variation. It has never been investigated if this variation is interindividual. Methods Lead and hemoglobin were determined in blood and plasma from 13 lead workers with a history of relatively high blood-lead concentrations, sampled three times during 1 day. The variation in the distribution of lead between cells and plasma was studied, but not the variation in the lead concentrations as such. Results Blood hemoglobin decreased with rising plasma lead (0.9-3.0 mu g/L). Regarding the distribution of lead, no effect of current exposure during the day or of recent meals appeared. As much as 84% of the overall variance of the distribution of lead between cells and plasma could be attributed to individual factors. After adjustment for erythrocyte volume fraction this decreased to 67%. Plasma samples with elevated hemoglobin concentrations (due to in vitro hemolysis) had somewhat elevated lead concentrations. Conclusions Plasma lead is not significantly altered by variation in a single day's exposure and, therefore, the choice of time of the day is not critical for sampling. However, plasma lead is negatively correlated to blood hemoglobin and mild hemolysis (not visible by the eye) in a sample may increase plasma lead with up to 30%. Finally, plasma provides lead exposure information that differs from whole blood, but it is not clear which one of these is the biomarker with the closest relation to exposure and/or effects. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
exposure, occupational, hemoglobin, hemolysis, biological monitoring, blood, lead, plasma
in
American Journal of Industrial Medicine
volume
49
issue
2
pages
93 - 101
publisher
John Wiley and Sons
external identifiers
  • pmid:16419091
  • wos:000235119300004
  • scopus:32344450148
  • pmid:16419091
ISSN
0271-3586
DOI
10.1002/ajim.20253
language
English
LU publication?
yes
id
57f021cb-6acc-4ea0-bda5-8916bc122da6 (old id 418281)
date added to LUP
2016-04-01 12:35:38
date last changed
2021-02-17 07:58:43
@article{57f021cb-6acc-4ea0-bda5-8916bc122da6,
  abstract     = {Background The lead concentration in plasma is correlated to that in whole blood with a two to fourfold variation. It has never been investigated if this variation is interindividual. Methods Lead and hemoglobin were determined in blood and plasma from 13 lead workers with a history of relatively high blood-lead concentrations, sampled three times during 1 day. The variation in the distribution of lead between cells and plasma was studied, but not the variation in the lead concentrations as such. Results Blood hemoglobin decreased with rising plasma lead (0.9-3.0 mu g/L). Regarding the distribution of lead, no effect of current exposure during the day or of recent meals appeared. As much as 84% of the overall variance of the distribution of lead between cells and plasma could be attributed to individual factors. After adjustment for erythrocyte volume fraction this decreased to 67%. Plasma samples with elevated hemoglobin concentrations (due to in vitro hemolysis) had somewhat elevated lead concentrations. Conclusions Plasma lead is not significantly altered by variation in a single day's exposure and, therefore, the choice of time of the day is not critical for sampling. However, plasma lead is negatively correlated to blood hemoglobin and mild hemolysis (not visible by the eye) in a sample may increase plasma lead with up to 30%. Finally, plasma provides lead exposure information that differs from whole blood, but it is not clear which one of these is the biomarker with the closest relation to exposure and/or effects.},
  author       = {Bergdahl, I A and Gerhardsson, Lars and Liljelind, IE and Nilsson, L and Skerfving, Staffan},
  issn         = {0271-3586},
  language     = {eng},
  number       = {2},
  pages        = {93--101},
  publisher    = {John Wiley and Sons},
  series       = {American Journal of Industrial Medicine},
  title        = {Plasma-lead concentration: investigations into its usefulness for biological monitoring of occupational lead exposure},
  url          = {http://dx.doi.org/10.1002/ajim.20253},
  doi          = {10.1002/ajim.20253},
  volume       = {49},
  year         = {2006},
}