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Clinical Protein Science and Targeted Mass Spectrometric Assays - New Frontiers in Disease Link and Biobanking

Végvári, Ákos LU and Marko-Varga, György LU (2014) p.157-173
Abstract
Today’s societies have to reach out for improved healthcare solutions due to the increased number of patients and changed disease profiles represented by the dominance of cardiovascular and neurodegenerative diseases as well as various forms of cancer that require customized therapies. There is an extensive need for diagnostic and therapeutic biomarkers that may also become targets for drug developments in the future. Modern analytical platforms headed by mass spectrometry offer enhanced sensitivity as well as novel methodologies with extreme specificity to identify and quantify these potential protein markers in clinical studies, which is in the focus of international research organized by the Human Proteome Organization. However, the... (More)
Today’s societies have to reach out for improved healthcare solutions due to the increased number of patients and changed disease profiles represented by the dominance of cardiovascular and neurodegenerative diseases as well as various forms of cancer that require customized therapies. There is an extensive need for diagnostic and therapeutic biomarkers that may also become targets for drug developments in the future. Modern analytical platforms headed by mass spectrometry offer enhanced sensitivity as well as novel methodologies with extreme specificity to identify and quantify these potential protein markers in clinical studies, which is in the focus of international research organized by the Human Proteome Organization. However, the complexity of clinical samples and the wide concentration range of proteins represent analytical tasks yet need to be accomplished. In this chapter we present the challenges the healthcare systems face nowadays and outline possible solutions using biobanking standardization, personalized medicine and mass spectrometric technologies with relevant examples. (Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
categories
Popular Science
host publication
Proteomics: Targeted Technology, Innovations and Applications
editor
LaBaer, Joshua and Fuentes, Manuel
pages
157 - 173
publisher
Horizon Scientific Press
ISBN
978-1-908230-46-1
language
English
LU publication?
yes
id
86cb6370-b4f3-4938-b73a-decb26f19bac (old id 4193470)
date added to LUP
2016-04-04 10:23:32
date last changed
2023-04-18 18:41:16
@inbook{86cb6370-b4f3-4938-b73a-decb26f19bac,
  abstract     = {{Today’s societies have to reach out for improved healthcare solutions due to the increased number of patients and changed disease profiles represented by the dominance of cardiovascular and neurodegenerative diseases as well as various forms of cancer that require customized therapies. There is an extensive need for diagnostic and therapeutic biomarkers that may also become targets for drug developments in the future. Modern analytical platforms headed by mass spectrometry offer enhanced sensitivity as well as novel methodologies with extreme specificity to identify and quantify these potential protein markers in clinical studies, which is in the focus of international research organized by the Human Proteome Organization. However, the complexity of clinical samples and the wide concentration range of proteins represent analytical tasks yet need to be accomplished. In this chapter we present the challenges the healthcare systems face nowadays and outline possible solutions using biobanking standardization, personalized medicine and mass spectrometric technologies with relevant examples.}},
  author       = {{Végvári, Ákos and Marko-Varga, György}},
  booktitle    = {{Proteomics: Targeted Technology, Innovations and Applications}},
  editor       = {{LaBaer, Joshua and Fuentes, Manuel}},
  isbn         = {{978-1-908230-46-1}},
  language     = {{eng}},
  pages        = {{157--173}},
  publisher    = {{Horizon Scientific Press}},
  title        = {{Clinical Protein Science and Targeted Mass Spectrometric Assays - New Frontiers in Disease Link and Biobanking}},
  year         = {{2014}},
}