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Drug Localizations in Tissue by Mass Spectrometry Imaging

Végvári, Ákos LU (2015) In Biomarkers in Medicine 9(9). p.869-876
Abstract
Advances in development of mass spectrometry (MS) are successfully utilized for spatial localization of pharmaceutical compounds in this tissue sections. Today MS instruments can be used in imaging mode when the datasets are generated from the surface of the tissue over an array of acquisition positions. This review is focused on the technological developments of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and related sample preparation procedures. MALDI-MSI provides a sensitive and label-free approach for imaging of drugs and their metabolites. Due to these features MALDI-MSI is expected to become a standard technique in pharmaceutical development providing complementary information to current methods.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cryo-microtome, MALDI matrix, MALDI-MSI
in
Biomarkers in Medicine
volume
9
issue
9
pages
869 - 876
publisher
Future Medicine Ltd.
external identifiers
  • pmid:26328625
  • wos:000362033300007
  • scopus:84942894557
ISSN
1752-0371
DOI
10.2217/bmm.15.64
language
English
LU publication?
yes
id
8b013ce4-4074-4476-8e12-69eaf5aecf6e (old id 4193473)
date added to LUP
2015-09-04 13:11:15
date last changed
2017-07-23 03:05:47
@article{8b013ce4-4074-4476-8e12-69eaf5aecf6e,
  abstract     = {Advances in development of mass spectrometry (MS) are successfully utilized for spatial localization of pharmaceutical compounds in this tissue sections. Today MS instruments can be used in imaging mode when the datasets are generated from the surface of the tissue over an array of acquisition positions. This review is focused on the technological developments of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and related sample preparation procedures. MALDI-MSI provides a sensitive and label-free approach for imaging of drugs and their metabolites. Due to these features MALDI-MSI is expected to become a standard technique in pharmaceutical development providing complementary information to current methods.},
  author       = {Végvári, Ákos},
  issn         = {1752-0371},
  keyword      = {Cryo-microtome,MALDI matrix,MALDI-MSI},
  language     = {eng},
  number       = {9},
  pages        = {869--876},
  publisher    = {Future Medicine Ltd.},
  series       = {Biomarkers in Medicine},
  title        = {Drug Localizations in Tissue by Mass Spectrometry Imaging},
  url          = {http://dx.doi.org/10.2217/bmm.15.64},
  volume       = {9},
  year         = {2015},
}