Advanced

Physiological and behavioral responses to an acute phase response in zebra finches: immediate and short-term effects

Sköld Chiriac, Sandra LU ; Nord, Andreas LU ; Nilsson, Jan-Åke LU and Hasselquist, Dennis LU (2014) In Physiological and Biochemical Zoology 87(2). p.288-298
Abstract
Activation of the immune system to clear pathogens and mitigate infection is a costly process that might incur fitness costs. When vertebrates are exposed to pathogens, their first line of defense is the acute-phase response (APR), which consists of a suite of physiological and behavioral changes. The dynamics of the APR are relatively well investigated in mammals and domesticated birds but still rather unexplored in passerine birds. In this study, we injected male zebra finches (Taeniopygia guttata) with a bacterial endotoxin (lipopolysaccharide [LPS]) to assess the potential physiological, immunological, and behavioral responses during the time course of an APR and also to record any potential short-term effects by measuring the birds... (More)
Activation of the immune system to clear pathogens and mitigate infection is a costly process that might incur fitness costs. When vertebrates are exposed to pathogens, their first line of defense is the acute-phase response (APR), which consists of a suite of physiological and behavioral changes. The dynamics of the APR are relatively well investigated in mammals and domesticated birds but still rather unexplored in passerine birds. In this study, we injected male zebra finches (Taeniopygia guttata) with a bacterial endotoxin (lipopolysaccharide [LPS]) to assess the potential physiological, immunological, and behavioral responses during the time course of an APR and also to record any potential short-term effects by measuring the birds during the days after the expected APR. We found that LPS-injected zebra finches decreased activity and gained less body mass during the APR, compared to control individuals. In addition, LPS-injected birds increased their production of LPS-reactive antibodies and reduced their metabolic rate during the days after the expected APR. Our results show that zebra finches demonstrate sickness behaviors during an APR but also that physiological effects persist after the expected time course of an APR. These delayed effects might be either a natural part of the progression of an APR, which is probably true for the antibody response, or a short-term carryover effect, which is probably true for the metabolic response. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physiological and Biochemical Zoology
volume
87
issue
2
pages
288 - 298
publisher
University of Chicago Press
external identifiers
  • pmid:24642546
  • wos:000332923400010
  • scopus:84896460652
ISSN
1522-2152
DOI
10.1086/674789
project
Costs of the immune system and maternal effects
language
English
LU publication?
yes
id
0c738ba9-45cc-4222-89e6-1158f5f6d6ed (old id 4196068)
alternative location
http://www.jstor.org/stable/10.1086/674789
date added to LUP
2014-02-28 11:01:46
date last changed
2017-09-17 03:26:29
@article{0c738ba9-45cc-4222-89e6-1158f5f6d6ed,
  abstract     = {Activation of the immune system to clear pathogens and mitigate infection is a costly process that might incur fitness costs. When vertebrates are exposed to pathogens, their first line of defense is the acute-phase response (APR), which consists of a suite of physiological and behavioral changes. The dynamics of the APR are relatively well investigated in mammals and domesticated birds but still rather unexplored in passerine birds. In this study, we injected male zebra finches (Taeniopygia guttata) with a bacterial endotoxin (lipopolysaccharide [LPS]) to assess the potential physiological, immunological, and behavioral responses during the time course of an APR and also to record any potential short-term effects by measuring the birds during the days after the expected APR. We found that LPS-injected zebra finches decreased activity and gained less body mass during the APR, compared to control individuals. In addition, LPS-injected birds increased their production of LPS-reactive antibodies and reduced their metabolic rate during the days after the expected APR. Our results show that zebra finches demonstrate sickness behaviors during an APR but also that physiological effects persist after the expected time course of an APR. These delayed effects might be either a natural part of the progression of an APR, which is probably true for the antibody response, or a short-term carryover effect, which is probably true for the metabolic response.},
  author       = {Sköld Chiriac, Sandra and Nord, Andreas and Nilsson, Jan-Åke and Hasselquist, Dennis},
  issn         = {1522-2152},
  language     = {eng},
  number       = {2},
  pages        = {288--298},
  publisher    = {University of Chicago Press},
  series       = {Physiological and Biochemical Zoology},
  title        = {Physiological and behavioral responses to an acute phase response in zebra finches: immediate and short-term effects},
  url          = {http://dx.doi.org/10.1086/674789},
  volume       = {87},
  year         = {2014},
}