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Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

Mathas, S ; Janz, M ; Hummel, F ; Hummel, M ; Wollert-Wulf, B ; Lusatis, S ; Anagnostopoulos, I ; Lietz, A ; Sigvardsson, Mikael LU and Jundt, F , et al. (2006) In Nature Immunology 7(2). p.207-215
Abstract
B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell-specific transcription factor program was disrupted by overexpression of the helix-loop-helix proteins ABF-1 and Id2. Both factors antagonized the function of the B cell-determining transcription factor E2A. As a result, expression of genes specific to B cells was lost and expression of genes not normally associated with the B lineage was upregulated. These data... (More)
B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell-specific transcription factor program was disrupted by overexpression of the helix-loop-helix proteins ABF-1 and Id2. Both factors antagonized the function of the B cell-determining transcription factor E2A. As a result, expression of genes specific to B cells was lost and expression of genes not normally associated with the B lineage was upregulated. These data demonstrate the plasticity of mature human lymphoid cells and offer an explanation for the unique classical Hodgkin lymphoma phenotype. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Immunology
volume
7
issue
2
pages
207 - 215
publisher
Nature Publishing Group
external identifiers
  • pmid:16369535
  • wos:000234801700022
  • scopus:31344451370
ISSN
1529-2908
DOI
10.1038/ni1285
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)
id
789ac8fe-5fb9-4a0b-b846-6223122bfda3 (old id 419698)
date added to LUP
2016-04-01 16:04:24
date last changed
2022-05-20 08:10:24
@article{789ac8fe-5fb9-4a0b-b846-6223122bfda3,
  abstract     = {{B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell-specific transcription factor program was disrupted by overexpression of the helix-loop-helix proteins ABF-1 and Id2. Both factors antagonized the function of the B cell-determining transcription factor E2A. As a result, expression of genes specific to B cells was lost and expression of genes not normally associated with the B lineage was upregulated. These data demonstrate the plasticity of mature human lymphoid cells and offer an explanation for the unique classical Hodgkin lymphoma phenotype.}},
  author       = {{Mathas, S and Janz, M and Hummel, F and Hummel, M and Wollert-Wulf, B and Lusatis, S and Anagnostopoulos, I and Lietz, A and Sigvardsson, Mikael and Jundt, F and Johrens, K and Bommert, K and Stein, H and Dorken, B}},
  issn         = {{1529-2908}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{207--215}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Immunology}},
  title        = {{Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma}},
  url          = {{http://dx.doi.org/10.1038/ni1285}},
  doi          = {{10.1038/ni1285}},
  volume       = {{7}},
  year         = {{2006}},
}