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Decreased serum level of macrophage inflammatory chemokine-3 beta/CCL19 in preterm labor and delivery

Laudanski, P ; Lemancewicz, A ; Pierzynski, P ; Åkerlund, Mats LU and Laudanski, T (2006) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 124(1). p.23-26
Abstract
Objective: Chemokines are small soluble molecules which mediate leukocyte migration and may be involved in the pathophysiology of preterm labor. We aimed to determine if serum concentrations of selected chemokines are changed in preterm labor and delivery. Study design: A novel array-based enzyme-linked immunosorbent assay was used to quantitate serum levels of nine chemokines from a single sample: MDC/CCL22, TARC/CCL17, ITAC/CXCL11, 1-309/CCL1, IP-10/CXCL10, MIP-1 alpha/CCL3, -1 beta/CCL4, -3 alpha/CCL20 and -3 beta/CCL19. Women in preterm labor who delivered (n = 17), women at preterm pregnancy not in labor (n = 13) and women in labor at term (n = 8) participated. Results: In the preterm delivery group of patients, the MIP-3 beta/CCL19... (More)
Objective: Chemokines are small soluble molecules which mediate leukocyte migration and may be involved in the pathophysiology of preterm labor. We aimed to determine if serum concentrations of selected chemokines are changed in preterm labor and delivery. Study design: A novel array-based enzyme-linked immunosorbent assay was used to quantitate serum levels of nine chemokines from a single sample: MDC/CCL22, TARC/CCL17, ITAC/CXCL11, 1-309/CCL1, IP-10/CXCL10, MIP-1 alpha/CCL3, -1 beta/CCL4, -3 alpha/CCL20 and -3 beta/CCL19. Women in preterm labor who delivered (n = 17), women at preterm pregnancy not in labor (n = 13) and women in labor at term (n = 8) participated. Results: In the preterm delivery group of patients, the MIP-3 beta/CCL19 concentration was in mean (+/- S.D.) 70.4 +/- 31.7 pg/mL, which was significantly lower than that in preterm gravidas not in labor of 123 +/- 34 pg/mL (p < 0.001) and those in labor at term of 118 +/- 25.6 pg/mL (p < 0.01). The other measured chemokines did not differ significantly. Conclusions: Of a small number of examined chemokines, we were able to show that one of them, MIP-3 beta/CCL19 was significantly lower in women with preterm labor and delivery. Whether or not this chemokine has a potential as biochemical marker of preterm delivery remains to be determined. (c) 2005 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
preterm labor, preterm delivery, MIP-3 beta/CCL19, chemokines, mini-array ELISA
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
124
issue
1
pages
23 - 26
publisher
Elsevier
external identifiers
  • wos:000234794100004
  • pmid:16023779
  • scopus:29644443420
  • pmid:16023779
ISSN
0301-2115
DOI
10.1016/j.ejogrb.2005.05.006
language
English
LU publication?
yes
id
a7c530b9-74f9-42c3-ae82-c382a1e480bb (old id 419895)
date added to LUP
2016-04-01 11:40:08
date last changed
2021-09-22 01:43:34
@article{a7c530b9-74f9-42c3-ae82-c382a1e480bb,
  abstract     = {Objective: Chemokines are small soluble molecules which mediate leukocyte migration and may be involved in the pathophysiology of preterm labor. We aimed to determine if serum concentrations of selected chemokines are changed in preterm labor and delivery. Study design: A novel array-based enzyme-linked immunosorbent assay was used to quantitate serum levels of nine chemokines from a single sample: MDC/CCL22, TARC/CCL17, ITAC/CXCL11, 1-309/CCL1, IP-10/CXCL10, MIP-1 alpha/CCL3, -1 beta/CCL4, -3 alpha/CCL20 and -3 beta/CCL19. Women in preterm labor who delivered (n = 17), women at preterm pregnancy not in labor (n = 13) and women in labor at term (n = 8) participated. Results: In the preterm delivery group of patients, the MIP-3 beta/CCL19 concentration was in mean (+/- S.D.) 70.4 +/- 31.7 pg/mL, which was significantly lower than that in preterm gravidas not in labor of 123 +/- 34 pg/mL (p &lt; 0.001) and those in labor at term of 118 +/- 25.6 pg/mL (p &lt; 0.01). The other measured chemokines did not differ significantly. Conclusions: Of a small number of examined chemokines, we were able to show that one of them, MIP-3 beta/CCL19 was significantly lower in women with preterm labor and delivery. Whether or not this chemokine has a potential as biochemical marker of preterm delivery remains to be determined. (c) 2005 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Laudanski, P and Lemancewicz, A and Pierzynski, P and Åkerlund, Mats and Laudanski, T},
  issn         = {0301-2115},
  language     = {eng},
  number       = {1},
  pages        = {23--26},
  publisher    = {Elsevier},
  series       = {European Journal of Obstetrics, Gynecology, and Reproductive Biology},
  title        = {Decreased serum level of macrophage inflammatory chemokine-3 beta/CCL19 in preterm labor and delivery},
  url          = {http://dx.doi.org/10.1016/j.ejogrb.2005.05.006},
  doi          = {10.1016/j.ejogrb.2005.05.006},
  volume       = {124},
  year         = {2006},
}