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Venous thromboembolism in ANCA-associated vasculitis : A population-based cohort study

Liapi, Matina ; Jayne, David ; Merkel, Peter A. ; Segelmark, Mårten LU and Mohammad, Aladdin J. LU (2021) In Rheumatology (United Kingdom) 60(10). p.4616-4623
Abstract

Objective: To determine incidence rate and predictors of venous thromboembolic events (VTE) in a population-based cohort with ANCA-associated vasculitis (AAV). Methods: The study comprised 325 patients diagnosed with AAV from 1997 to 2016. All cases of VTE from prior to vasculitis diagnosis to the end of the study period were identified. The BVAS was used to assess disease activity at diagnosis. Venous thromboembolisms occurring in a period beginning 3 months prior to AAV diagnosis were considered to be AAV-related. The standardized incidence ratio (SIR) and 95% CI of VTE were calculated using the incidence rate in the general population. Results: Fifty-nine patients (18%) suffered 64 VTE events. Of these, 48 (81%) suffered AAV-related... (More)

Objective: To determine incidence rate and predictors of venous thromboembolic events (VTE) in a population-based cohort with ANCA-associated vasculitis (AAV). Methods: The study comprised 325 patients diagnosed with AAV from 1997 to 2016. All cases of VTE from prior to vasculitis diagnosis to the end of the study period were identified. The BVAS was used to assess disease activity at diagnosis. Venous thromboembolisms occurring in a period beginning 3 months prior to AAV diagnosis were considered to be AAV-related. The standardized incidence ratio (SIR) and 95% CI of VTE were calculated using the incidence rate in the general population. Results: Fifty-nine patients (18%) suffered 64 VTE events. Of these, 48 (81%) suffered AAV-related VTE [deep vein thrombosis (n = 23), pulmonary embolism (n = 18) and other (n = 9)]. The incidence rate of AAV-related VTE was 2.4 per 100 person-years (95% CI 1.7, 3.0) during 2039 person-years of follow-up. The incidence during the first 3 months post-AAV diagnosis was 20.4 per 100 person-years (95% CI 11.5, 29.4), decreasing to 8.9 (95% CI 0.2, 17.6) and 1.5 (95% CI 0.0, 3.5) in months 4-6 and months 7-12 post-AAV diagnosis, respectively. The SIR was 34.2 (95% CI 20.2, 48.1) for deep vein thrombosis and 10.4 (95% CI 5.6, 15.1) for pulmonary embolism. In multivariate Cox regression analyses, only age and BVAS were predictive of VTE. Conclusions: The incidence rate and SIR of AAV-related VTE is high, and higher early in the course of the disease. Vasculitis activity and age are positively associated with VTE.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ANCA, Thromboembolism, Vasculitis
in
Rheumatology (United Kingdom)
volume
60
issue
10
pages
8 pages
publisher
Oxford University Press
external identifiers
  • scopus:85116366201
  • pmid:33506869
ISSN
1462-0324
DOI
10.1093/rheumatology/keab057
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 The Author(s) 2021.
id
41bb09e6-d97f-4c2e-8895-f09a01a23051
date added to LUP
2022-02-23 09:00:30
date last changed
2024-06-14 13:26:30
@article{41bb09e6-d97f-4c2e-8895-f09a01a23051,
  abstract     = {{<p>Objective: To determine incidence rate and predictors of venous thromboembolic events (VTE) in a population-based cohort with ANCA-associated vasculitis (AAV). Methods: The study comprised 325 patients diagnosed with AAV from 1997 to 2016. All cases of VTE from prior to vasculitis diagnosis to the end of the study period were identified. The BVAS was used to assess disease activity at diagnosis. Venous thromboembolisms occurring in a period beginning 3 months prior to AAV diagnosis were considered to be AAV-related. The standardized incidence ratio (SIR) and 95% CI of VTE were calculated using the incidence rate in the general population. Results: Fifty-nine patients (18%) suffered 64 VTE events. Of these, 48 (81%) suffered AAV-related VTE [deep vein thrombosis (n = 23), pulmonary embolism (n = 18) and other (n = 9)]. The incidence rate of AAV-related VTE was 2.4 per 100 person-years (95% CI 1.7, 3.0) during 2039 person-years of follow-up. The incidence during the first 3 months post-AAV diagnosis was 20.4 per 100 person-years (95% CI 11.5, 29.4), decreasing to 8.9 (95% CI 0.2, 17.6) and 1.5 (95% CI 0.0, 3.5) in months 4-6 and months 7-12 post-AAV diagnosis, respectively. The SIR was 34.2 (95% CI 20.2, 48.1) for deep vein thrombosis and 10.4 (95% CI 5.6, 15.1) for pulmonary embolism. In multivariate Cox regression analyses, only age and BVAS were predictive of VTE. Conclusions: The incidence rate and SIR of AAV-related VTE is high, and higher early in the course of the disease. Vasculitis activity and age are positively associated with VTE. </p>}},
  author       = {{Liapi, Matina and Jayne, David and Merkel, Peter A. and Segelmark, Mårten and Mohammad, Aladdin J.}},
  issn         = {{1462-0324}},
  keywords     = {{ANCA; Thromboembolism; Vasculitis}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  pages        = {{4616--4623}},
  publisher    = {{Oxford University Press}},
  series       = {{Rheumatology (United Kingdom)}},
  title        = {{Venous thromboembolism in ANCA-associated vasculitis : A population-based cohort study}},
  url          = {{http://dx.doi.org/10.1093/rheumatology/keab057}},
  doi          = {{10.1093/rheumatology/keab057}},
  volume       = {{60}},
  year         = {{2021}},
}