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Case-control study on concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus antigens in the etiology of non-Hodgkin lymphoma

Hardell, L. ; Eriksson, M. LU orcid ; Lindström, G. ; Van Bavel, B. ; Linde, A. ; Carlberg, M. and Liljegren, G. (2001) In Leukemia and Lymphoma 42(4). p.619-629
Abstract

A rapid increase in incidence of non-Hodgkin lymphoma (NHL) has been reported from many countries. Exposure to certain pesticides and organochlorines has been shown to be risk factors. Epstein-Barr virus (EBV) is a human herpesvirus that has been associated with some subgroups of NHL, such as Burkitt lymphoma and lymphomas related to severe immunosuppression. In this study, we measured lipid adjusted blood concentrations of 36 congeners of polychlorinated biphenyls (PCBs), p,p′-dichlorodiphenyl-dichloroethylene (p,p′-DDE), hexachlorobenzene (HCB), four different subgroups of chlordanes (trans-nonachlordane, cis-nonachlordane, MC6 and oxychlordane) and 2,2′,4,4′-tetrabrominated diphenyl ether (TBDE) in incident cases of NHL and controls... (More)

A rapid increase in incidence of non-Hodgkin lymphoma (NHL) has been reported from many countries. Exposure to certain pesticides and organochlorines has been shown to be risk factors. Epstein-Barr virus (EBV) is a human herpesvirus that has been associated with some subgroups of NHL, such as Burkitt lymphoma and lymphomas related to severe immunosuppression. In this study, we measured lipid adjusted blood concentrations of 36 congeners of polychlorinated biphenyls (PCBs), p,p′-dichlorodiphenyl-dichloroethylene (p,p′-DDE), hexachlorobenzene (HCB), four different subgroups of chlordanes (trans-nonachlordane, cis-nonachlordane, MC6 and oxychlordane) and 2,2′,4,4′-tetrabrominated diphenyl ether (TBDE) in incident cases of NHL and controls from the general population. Titers of antibodies to the Epstein-Barr early antigen (EA) were correlated to concentrations of organochlorines. We found a significant difference in lipid adjusted blood concentrations of total PCBs and TBDE between cases and controls. Titers of antibodies to EA IgG> 80 were correlated to an increased risk for NHL with odds ratio (OR) =1.9, 95% confidence interval (CI) =0.94-3.8. This risk was further increased in those with a level above the median value of "sum of PCBs" (OR=4.0, CI=1.2-14), HCB (OR=5.3, CI=1.6-19), sum of chlordanes (OR=4.0, CI=1.2-14) and TBDE (OR=21, CI=4.6-124), suggesting an interaction between EBV and a higher concentration of these chemicals. Also for the "sum of immunotoxic PCBs" increased risk was found in that group (OR=6.4, CI=1.9-24). Subdivision of NHL in histological types yielded highest risks for low-grade B-cell NHL.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chlordane, DDE, Epstein-Barr virus, Etiology, Hexachlorobenzene, Non-Hodgkin lymphoma, PCB, Tetrabrominated diphenyl ether
in
Leukemia and Lymphoma
volume
42
issue
4
pages
619 - 629
publisher
Taylor & Francis
external identifiers
  • pmid:11697490
  • scopus:0034861750
ISSN
1042-8194
DOI
10.3109/10428190109099322
language
English
LU publication?
no
id
41c299a4-c5d0-4300-af05-6bcb9c5dbbe4
date added to LUP
2020-02-24 10:42:54
date last changed
2024-03-04 15:00:40
@article{41c299a4-c5d0-4300-af05-6bcb9c5dbbe4,
  abstract     = {{<p>A rapid increase in incidence of non-Hodgkin lymphoma (NHL) has been reported from many countries. Exposure to certain pesticides and organochlorines has been shown to be risk factors. Epstein-Barr virus (EBV) is a human herpesvirus that has been associated with some subgroups of NHL, such as Burkitt lymphoma and lymphomas related to severe immunosuppression. In this study, we measured lipid adjusted blood concentrations of 36 congeners of polychlorinated biphenyls (PCBs), p,p′-dichlorodiphenyl-dichloroethylene (p,p′-DDE), hexachlorobenzene (HCB), four different subgroups of chlordanes (trans-nonachlordane, cis-nonachlordane, MC6 and oxychlordane) and 2,2′,4,4′-tetrabrominated diphenyl ether (TBDE) in incident cases of NHL and controls from the general population. Titers of antibodies to the Epstein-Barr early antigen (EA) were correlated to concentrations of organochlorines. We found a significant difference in lipid adjusted blood concentrations of total PCBs and TBDE between cases and controls. Titers of antibodies to EA IgG&gt; 80 were correlated to an increased risk for NHL with odds ratio (OR) =1.9, 95% confidence interval (CI) =0.94-3.8. This risk was further increased in those with a level above the median value of "sum of PCBs" (OR=4.0, CI=1.2-14), HCB (OR=5.3, CI=1.6-19), sum of chlordanes (OR=4.0, CI=1.2-14) and TBDE (OR=21, CI=4.6-124), suggesting an interaction between EBV and a higher concentration of these chemicals. Also for the "sum of immunotoxic PCBs" increased risk was found in that group (OR=6.4, CI=1.9-24). Subdivision of NHL in histological types yielded highest risks for low-grade B-cell NHL.</p>}},
  author       = {{Hardell, L. and Eriksson, M. and Lindström, G. and Van Bavel, B. and Linde, A. and Carlberg, M. and Liljegren, G.}},
  issn         = {{1042-8194}},
  keywords     = {{Chlordane; DDE; Epstein-Barr virus; Etiology; Hexachlorobenzene; Non-Hodgkin lymphoma; PCB; Tetrabrominated diphenyl ether}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{4}},
  pages        = {{619--629}},
  publisher    = {{Taylor & Francis}},
  series       = {{Leukemia and Lymphoma}},
  title        = {{Case-control study on concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus antigens in the etiology of non-Hodgkin lymphoma}},
  url          = {{http://dx.doi.org/10.3109/10428190109099322}},
  doi          = {{10.3109/10428190109099322}},
  volume       = {{42}},
  year         = {{2001}},
}