Discovery and refinement of loci associated with lipid levels
(2013) In Nature Genetics 45(11). p.1274-1274- Abstract
- Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and... (More)
- Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research. (Less)
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https://lup.lub.lu.se/record/4204583
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- publishing date
- 2013
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- Contribution to journal
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- published
- subject
- in
- Nature Genetics
- volume
- 45
- issue
- 11
- pages
- 1274 - 1274
- publisher
- Nature Publishing Group
- external identifiers
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- wos:000326384100007
- scopus:84887099827
- pmid:24097068
- ISSN
- 1546-1718
- DOI
- 10.1038/ng.2797
- language
- English
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- yes
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- 4f07f785-c869-40bb-9154-2164c325b5a9 (old id 4204583)
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@article{4f07f785-c869-40bb-9154-2164c325b5a9,
abstract = {{Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.}},
author = {{Willer, Cristen J. and Schmidt, Ellen M. and Sengupta, Sebanti and Peloso, Gina M. and Gustafsson, Stefan and Kanoni, Stavroula and Ganna, Andrea and Chen, Jin and Buchkovich, Martin L. and Mora, Samia and Beckmann, Jacques S. and Bragg-Gresham, Jennifer L. and Chang, Hsing-Yi and Demirkan, Ayse and Den Hertog, Heleen M. and Do, Ron and Donnelly, Louise A. and Ehret, Georg B. and Esko, Tonu and Feitosa, Mary F. and Ferreira, Teresa and Fischer, Krista and Fontanillas, Pierre and Fraser, Ross M. and Freitag, Daniel F. and Gurdasani, Deepti and Heikkila, Kauko and Hyppoenen, Elina and Isaacs, Aaron and Jackson, Anne U. and Johansson, Asa and Johnson, Toby and Kaakinen, Marika and Kettunen, Johannes and Kleber, Marcus E. and Li, Xiaohui and Luan, Jian'an and Lyytikainen, Leo-Pekka and Magnusson, Patrik K. E. and Mangino, Massimo and Mihailov, Evelin and Montasser, May E. and Mueller-Nurasyid, Martina and Nolte, Ilja M. and O'Connell, Jeffrey R. and Palmer, Cameron D. and Perola, Markus and Petersen, Ann-Kristin and Sanna, Serena and Saxena, Richa and Service, Susan K. and Shah, Sonia and Shungin, Dmitry and Sidore, Carlo and Song, Ci and Strawbridge, Rona J. and Surakka, Ida and Tanaka, Toshiko and Teslovich, Tanya M. and Thorleifsson, Gudmar and Van den Herik, Evita G. and Voight, Benjamin F. and Volcik, Kelly A. and Waite, Lindsay L. and Wong, Andrew and Wu, Ying and Zhang, Weihua and Absher, Devin and Asiki, Gershim and Barroso, Ines and Been, Latonya F. and Bolton, Jennifer L. and Bonnycastle, Lori L. and Brambilla, Paolo and Burnett, Mary S. and Cesana, Giancarlo and Dimitriou, Maria and Doney, Alex S. F. and Doering, Angela and Elliott, Paul and Epstein, Stephen E. and Eyjolfsson, Gudmundur Ingi and Gigante, Bruna and Goodarzi, Mark O. and Grallert, Harald and Gravito, Martha L. and Groves, Christopher J. and Hallmans, Goran and Hartikainen, Anna-Liisa and Hayward, Caroline and Hernandez, Dena and Hicks, Andrew A. and Holm, Hilma and Hung, Yi-Jen and Illig, Thomas and Jones, Michelle R. and Kaleebu, Pontiano and Kastelein, John J. P. and Khaw, Kay-Tee and Kim, Eric and Klopp, Norman and Komulainen, Pirjo and Kumari, Meena and Langenberg, Claudia and Lehtimaki, Terho and Lin, Shih-Yi and Lindstrom, Jaana and Loos, Ruth J. F. and Mach, Francois and McArdle, Wendy L. and Meisinger, Christa and Mitchell, Braxton D. and Mueller, Gabrielle and Nagaraja, Ramaiah and Narisu, Narisu and Nieminen, Tuomo V. M. and Nsubuga, Rebecca N. and Olafsson, Isleifur and Ong, Ken K. and Palotie, Aarno and Papamarkou, Theodore and Pomilla, Cristina and Pouta, Anneli and Rader, Daniel J. and Reilly, Muredach P. and Ridker, Paul M. and Rivadeneira, Fernando and Rudan, Igor and Ruokonen, Aimo and Samani, Nilesh and Scharnagl, Hubert and Seeley, Janet and Silander, Kaisa and Stancakova, Alena and Stirrups, Kathleen and Swift, Amy J. and Tiret, Laurence and Uitterlinden, Andre G. and van Pelt, L. Joost and Vedantam, Sailaja and Wainwright, Nicholas and Wijmenga, Cisca and Wild, Sarah H. and Willemsen, Gonneke and Wilsgaard, Tom and Wilson, James F. and Young, Elizabeth H. and Zhao, Jing Hua and Adair, Linda S. and Arveiler, Dominique and Assimes, Themistocles L. and Bandinelli, Stefania and Bennett, Franklyn and Bochud, Murielle and Boehm, Bernhard O. and Boomsma, Dorret I. and Borecki, Ingrid B. and Bornstein, Stefan R. and Bovet, Pascal and Burnier, Michel and Campbell, Harry and Chakravarti, Aravinda and Chambers, John C. and Chen, Yii-Der Ida and Collins, Francis S. and Cooper, Richard S. and Danesh, John and Dedoussis, George and de Faire, Ulf and Feranil, Alan B. and Ferrieres, Jean and Ferrucci, Luigi and Freimer, Nelson B. and Gieger, Christian and Groop, Leif and Gudnason, Vilmundur and Gyllensten, Ulf and Hamsten, Anders and Harris, Tamara B. and Hingorani, Aroon and Hirschhorn, Joel N. and Hofman, Albert and Hovingh, G. Kees and Hsiung, Chao Agnes and Humphries, Steve E. and Hunt, Steven C. and Hveem, Kristian and Iribarren, Carlos and Jarvelin, Marjo-Riitta and Jula, Antti and Kahonen, Mika and Kaprio, Jaakko and Kesaniemi, Antero and Kivimaki, Mika and Kooner, Jaspal S. and Koudstaal, Peter J. and Krauss, Ronald M. and Kuh, Diana and Kuusisto, Johanna and Kyvik, Kirsten O. and Laakso, Markku and Lakka, Timo A. and Lind, Lars and Lindgren, Cecilia M. and Martin, Nicholas G. and Maerz, Winfried and McCarthy, Mark I. and McKenzie, Colin A. and Meneton, Pierre and Metspalu, Andres and Moilanen, Leena and Morris, Andrew D. and Munroe, Patricia B. and Njolstad, Inger and Pedersen, Nancy L. and Power, Chris and Pramstaller, Peter P. and Price, Jackie F. and Psaty, Bruce M. and Quertermous, Thomas and Rauramaa, Rainer and Saleheen, Danish and Salomaa, Veikko and Sanghera, Dharambir K. and Saramies, Jouko and Schwarz, Peter E. H. and Sheu, Wayne H-H and Shuldiner, Alan R. and Siegbahn, Agneta and Spector, Tim D. and Stefansson, Kari and Strachan, David P. and Tayo, Bamidele O. and Tremoli, Elena and Tuomilehto, Jaakko and Uusitupa, Matti and van Duijn, Cornelia M. and Vollenweider, Peter and Wallentin, Lars and Wareham, Nicholas J. and Whitfield, John B. and Wolffenbuttel, Bruce H. R. and Ordovas, Jose M. and Boerwinkle, Eric and Palmer, Colin N. A. and Thorsteinsdottir, Unnur and Chasman, Daniel I. and Rotter, Jerome I. and Franks, Paul and Ripatti, Samuli and Cupples, L. Adrienne and Sandhu, Manjinder S. and Rich, Stephen S. and Boehnke, Michael and Deloukas, Panos and Kathiresan, Sekar and Mohlke, Karen L. and Ingelsson, Erik and Abecasis, Goncalo R.}},
issn = {{1546-1718}},
language = {{eng}},
number = {{11}},
pages = {{1274--1274}},
publisher = {{Nature Publishing Group}},
series = {{Nature Genetics}},
title = {{Discovery and refinement of loci associated with lipid levels}},
url = {{http://dx.doi.org/10.1038/ng.2797}},
doi = {{10.1038/ng.2797}},
volume = {{45}},
year = {{2013}},
}