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Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA2 and cardiovascular diseases

Ballantyne, C. ; Cushman, M. ; Psaty, B. ; Furberg, C. ; Khaw, K. T. ; Sandhu, M. ; Oldgren, J. ; Rossi, G. P. ; Maiolino, G. and Cesari, M. , et al. (2007) In European Journal of Preventive Cardiology 14(1). p.3-11
Abstract

A large number of observational epidemiological studies have reported generally positive associations between circulating mass and activity levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and the risk of cardiovascular diseases. Few studies have been large enough to provide reliable estimates in different circumstances, such as in different subgroups (e.g., by age group, sex, or smoking status) or at different Lp-PLA2 levels. Moreover, most published studies have related disease risk only to baseline values of Lp-PLA2 markers (which can lead to substantial underestimation of any risk relationships because of within-person variability over time) and have used different approaches to adjustment... (More)

A large number of observational epidemiological studies have reported generally positive associations between circulating mass and activity levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and the risk of cardiovascular diseases. Few studies have been large enough to provide reliable estimates in different circumstances, such as in different subgroups (e.g., by age group, sex, or smoking status) or at different Lp-PLA2 levels. Moreover, most published studies have related disease risk only to baseline values of Lp-PLA2 markers (which can lead to substantial underestimation of any risk relationships because of within-person variability over time) and have used different approaches to adjustment for possible confounding factors. By combination of data from individual participants from all relevant observational studies in a systematic ‘meta-analysis', with correction for regression dilution (using available data on serial measurements of Lp-PLA2), the Lp-PLA2 Studies Collaboration will aim to characterize more precisely than has previously been possible the strength and shape of the age and sex-specific associations of plasma Lp-PLA2 with coronary heart disease (and, where data are sufficient, with other vascular diseases, such as ischaemic stroke). It will also help to determine to what extent such associations are independent of possible confounding factors and to explore potential sources of heterogeneity among studies, such as those related to assay methods and study design. It is anticipated that the present collaboration will serve as a framework to investigate related questions on Lp-PLA2 and cardiovascular outcomes. A central database is being established containing data on circulating Lp-PLA2 values, sex and other potential confounding factors, age at baseline Lp-PLA2 measurement, age at event or at last follow-up, major vascular morbidity and cause-specific mortality. Information about any repeat measurements of Lp-PLA2 and potential confounding factors has been sought to allow adjustment for possible confounding and correction for regression dilution. The analyses will involve age-specific regression models. Synthesis of the available observational studies of Lp-PLA2 will yield information on a total of about 15 000 cardiovascular disease endpoints.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lipoprotein-associated phospholipase A2, meta-analysis, vascular disease
in
European Journal of Preventive Cardiology
volume
14
issue
1
pages
9 pages
publisher
Oxford University Press
external identifiers
  • pmid:17301621
  • scopus:85081413795
ISSN
2047-4873
DOI
10.1097/01.hjr.0000239464.18509.f1
language
English
LU publication?
yes
id
420db229-f22d-4c2b-9c66-20c3bb812513
date added to LUP
2019-06-24 09:43:02
date last changed
2020-12-10 12:21:40
@article{420db229-f22d-4c2b-9c66-20c3bb812513,
  abstract     = {<p>A large number of observational epidemiological studies have reported generally positive associations between circulating mass and activity levels of lipoprotein-associated phospholipase A<sub>2</sub> (Lp-PLA<sub>2</sub>) and the risk of cardiovascular diseases. Few studies have been large enough to provide reliable estimates in different circumstances, such as in different subgroups (e.g., by age group, sex, or smoking status) or at different Lp-PLA2 levels. Moreover, most published studies have related disease risk only to baseline values of Lp-PLA<sub>2</sub> markers (which can lead to substantial underestimation of any risk relationships because of within-person variability over time) and have used different approaches to adjustment for possible confounding factors. By combination of data from individual participants from all relevant observational studies in a systematic ‘meta-analysis', with correction for regression dilution (using available data on serial measurements of Lp-PLA<sub>2</sub>), the Lp-PLA<sub>2</sub> Studies Collaboration will aim to characterize more precisely than has previously been possible the strength and shape of the age and sex-specific associations of plasma Lp-PLA<sub>2</sub> with coronary heart disease (and, where data are sufficient, with other vascular diseases, such as ischaemic stroke). It will also help to determine to what extent such associations are independent of possible confounding factors and to explore potential sources of heterogeneity among studies, such as those related to assay methods and study design. It is anticipated that the present collaboration will serve as a framework to investigate related questions on Lp-PLA<sub>2</sub> and cardiovascular outcomes. A central database is being established containing data on circulating Lp-PLA<sub>2</sub> values, sex and other potential confounding factors, age at baseline Lp-PLA<sub>2</sub> measurement, age at event or at last follow-up, major vascular morbidity and cause-specific mortality. Information about any repeat measurements of Lp-PLA<sub>2</sub> and potential confounding factors has been sought to allow adjustment for possible confounding and correction for regression dilution. The analyses will involve age-specific regression models. Synthesis of the available observational studies of Lp-PLA2 will yield information on a total of about 15 000 cardiovascular disease endpoints.</p>},
  author       = {Ballantyne, C. and Cushman, M. and Psaty, B. and Furberg, C. and Khaw, K. T. and Sandhu, M. and Oldgren, J. and Rossi, G. P. and Maiolino, G. and Cesari, M. and Lenzini, L. and James, S. K. and Rimm, E. and Collins, R. and Anderson, J. and Koenig, W. and Brenner, H. and Rothenbacher, D. and Berglund, G. and Persson, M. and Berger, P. and Brilakis, E. and McConnell, J. P. and Sacco, R. and Elkind, M. and Talmud, P. and Cannon, C. P. and Packard, C. and Barrett-Connor, E. and Hofman, A. and Kardys, I. and Witteman, J. C. and Criqui, M. and Corsetti, J. P. and Rainwater, D. L. and Moss, A. J. and Robins, S. and Bloomfield, H. and Collins, D. and Wassertheil-Smoller, S. and Ridker, P. and Danesh, J. and Gu, D. and Nelson, J. J. and Thompson, S. and Zalewski, A. and Zariffa, N. and Di Angelantonio, E. and Kaptoge, S. and Thompson, A.},
  issn         = {2047-4873},
  language     = {eng},
  month        = {02},
  number       = {1},
  pages        = {3--11},
  publisher    = {Oxford University Press},
  series       = {European Journal of Preventive Cardiology},
  title        = {Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA2 and cardiovascular diseases},
  url          = {http://dx.doi.org/10.1097/01.hjr.0000239464.18509.f1},
  doi          = {10.1097/01.hjr.0000239464.18509.f1},
  volume       = {14},
  year         = {2007},
}