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Generation of molecular recognition sites in electrospun polymer nanofibers via molecular imprinting

Chronakis, IS ; Milosevic, B ; Frenot, A and Ye, Lei LU orcid (2006) In Macromolecules 39(1). p.357-361
Abstract
A simple method for the formation of molecular recognition sites in polymer nanofibers was developed. Electrospun nanofibers were prepared from a Solution mixture of poly(ethylene terephthalate) (PET) and polyallylamine in the presence of a template molecule, 2,4-dichlorophenoxyacetic acid (2,4-D). The polyamine was used to provide functional groups that interact with the template during the electrospinning process, and PET acted as a major supporting matrix to ensure easy fiber formation and to minimize the conformational change of the polymers when the nanofibers were subjected to different solvent treatments. When the template was removed by solvent extraction, imprinted binding sites were left in the nanofiber materials that are... (More)
A simple method for the formation of molecular recognition sites in polymer nanofibers was developed. Electrospun nanofibers were prepared from a Solution mixture of poly(ethylene terephthalate) (PET) and polyallylamine in the presence of a template molecule, 2,4-dichlorophenoxyacetic acid (2,4-D). The polyamine was used to provide functional groups that interact with the template during the electrospinning process, and PET acted as a major supporting matrix to ensure easy fiber formation and to minimize the conformational change of the polymers when the nanofibers were subjected to different solvent treatments. When the template was removed by solvent extraction, imprinted binding sites were left in the nanofiber materials that are capable of selectively rebinding the target molecule. The molecularly imprinted nanofibers were characterized by SEM, FT-IR, and radioligand binding analysis. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Macromolecules
volume
39
issue
1
pages
357 - 361
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000234500100053
  • scopus:30944450861
ISSN
0024-9297
DOI
10.1021/ma052091w
language
English
LU publication?
yes
id
82b85cab-34da-45b6-ae00-2967f4a6e3b7 (old id 421268)
date added to LUP
2016-04-01 11:56:22
date last changed
2021-08-25 04:44:55
@article{82b85cab-34da-45b6-ae00-2967f4a6e3b7,
  abstract     = {A simple method for the formation of molecular recognition sites in polymer nanofibers was developed. Electrospun nanofibers were prepared from a Solution mixture of poly(ethylene terephthalate) (PET) and polyallylamine in the presence of a template molecule, 2,4-dichlorophenoxyacetic acid (2,4-D). The polyamine was used to provide functional groups that interact with the template during the electrospinning process, and PET acted as a major supporting matrix to ensure easy fiber formation and to minimize the conformational change of the polymers when the nanofibers were subjected to different solvent treatments. When the template was removed by solvent extraction, imprinted binding sites were left in the nanofiber materials that are capable of selectively rebinding the target molecule. The molecularly imprinted nanofibers were characterized by SEM, FT-IR, and radioligand binding analysis.},
  author       = {Chronakis, IS and Milosevic, B and Frenot, A and Ye, Lei},
  issn         = {0024-9297},
  language     = {eng},
  number       = {1},
  pages        = {357--361},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Macromolecules},
  title        = {Generation of molecular recognition sites in electrospun polymer nanofibers via molecular imprinting},
  url          = {http://dx.doi.org/10.1021/ma052091w},
  doi          = {10.1021/ma052091w},
  volume       = {39},
  year         = {2006},
}