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Molecularly emprinted polymer microspheres prepared by precipitation polymerization using a sacrificial covalent bond

Boonpangrak, Somchai LU ; Prachayasittikul, V ; Bülow, Leif LU and Ye, Lei LU orcid (2006) In Journal of Applied Polymer Science 99(4). p.1390-1398
Abstract
Molecularly imprinted polymer microspheres were prepared by precipitation polymerization using a sacrificial covalent bond. In the present model, cholesteryl (4-vinyl)phenyl carbonate was used as a template monomer. The imprinted microspheres were prepared using ethylene glycol dimethacrylate (EDMA) and divinylbenzene (DVB) as crosslinker. The base-labile carbonate ester bond was easily hydrolyzed to leave imprinted cavities in the resulting polymers. Radioligand binding analysis, elemental analysis, and scanning electron microscopy were used to characterize the imprinted materials. Imprinted microspheres prepared from DVB crosslinker had larger and more defined spherical shape, and displayed better imprinting effect than did the... (More)
Molecularly imprinted polymer microspheres were prepared by precipitation polymerization using a sacrificial covalent bond. In the present model, cholesteryl (4-vinyl)phenyl carbonate was used as a template monomer. The imprinted microspheres were prepared using ethylene glycol dimethacrylate (EDMA) and divinylbenzene (DVB) as crosslinker. The base-labile carbonate ester bond was easily hydrolyzed to leave imprinted cavities in the resulting polymers. Radioligand binding analysis, elemental analysis, and scanning electron microscopy were used to characterize the imprinted materials. Imprinted microspheres prepared from DVB crosslinker had larger and more defined spherical shape, and displayed better imprinting effect than did the EDMA-based microparticles. For comparison, imprinted bulk polymers were also prepared in the same reaction solvent as that used in precipitation polymerization. Elemental analysis results indicated that imprinted microspheres contained more template monomer units than bulk materials. The efficiency of template removal by hydrolysis treatment for microspheres was also higher than that for bulk polymers. For DVB-based polymers, imprinted microspheres displayed higher specific cholesterol uptake than did the corresponding bulk polymer. (c) 2005 Wiley Periodicals, Inc. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cholesterol, microspheres, molecular imprinting, precipitation polymerization
in
Journal of Applied Polymer Science
volume
99
issue
4
pages
1390 - 1398
publisher
John Wiley and Sons
external identifiers
  • wos:000234441200012
  • scopus:33645140905
ISSN
1097-4628
DOI
10.1002/app.22519
language
English
LU publication?
yes
id
bc6b0d40-737a-423c-b8cc-34936ebd6300 (old id 421523)
date added to LUP
2016-04-01 12:01:15
date last changed
2021-08-25 01:42:27
@article{bc6b0d40-737a-423c-b8cc-34936ebd6300,
  abstract     = {Molecularly imprinted polymer microspheres were prepared by precipitation polymerization using a sacrificial covalent bond. In the present model, cholesteryl (4-vinyl)phenyl carbonate was used as a template monomer. The imprinted microspheres were prepared using ethylene glycol dimethacrylate (EDMA) and divinylbenzene (DVB) as crosslinker. The base-labile carbonate ester bond was easily hydrolyzed to leave imprinted cavities in the resulting polymers. Radioligand binding analysis, elemental analysis, and scanning electron microscopy were used to characterize the imprinted materials. Imprinted microspheres prepared from DVB crosslinker had larger and more defined spherical shape, and displayed better imprinting effect than did the EDMA-based microparticles. For comparison, imprinted bulk polymers were also prepared in the same reaction solvent as that used in precipitation polymerization. Elemental analysis results indicated that imprinted microspheres contained more template monomer units than bulk materials. The efficiency of template removal by hydrolysis treatment for microspheres was also higher than that for bulk polymers. For DVB-based polymers, imprinted microspheres displayed higher specific cholesterol uptake than did the corresponding bulk polymer. (c) 2005 Wiley Periodicals, Inc.},
  author       = {Boonpangrak, Somchai and Prachayasittikul, V and Bülow, Leif and Ye, Lei},
  issn         = {1097-4628},
  language     = {eng},
  number       = {4},
  pages        = {1390--1398},
  publisher    = {John Wiley and Sons},
  series       = {Journal of Applied Polymer Science},
  title        = {Molecularly emprinted polymer microspheres prepared by precipitation polymerization using a sacrificial covalent bond},
  url          = {http://dx.doi.org/10.1002/app.22519},
  doi          = {10.1002/app.22519},
  volume       = {99},
  year         = {2006},
}