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Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States

Landgren, O ; Gridley, G ; Turesson, Ingemar LU ; Caporaso, NE ; Goldin, LR ; Baris, D ; Fears, TR ; Hoover, RN and Linet, MS (2006) In Blood 107(3). p.904-906
Abstract
The age-adjusted incidence of multiple myeloma (MM) is 2-fold higher in African Americans than in whites. A few small studies have reported a higher prevalence of monoclonal gammopathy of undetermined significance (MGUS) in African Americans versus whites. Etiologic factors for MGUS and determinants for transformation of MGUS to MM are unknown. We quantified the prevalence of MGUS and subsequent risk of MM among 4 million African American and white male veterans admitted to Veterans Affairs (VA) hospitals. The age-adjusted prevalence ratio of MGUS in African Americans compared with whites was 3.0 (2.7-3.3 95% confidence interval). Among 2046 MGUS cases, the estimated cumulative risk of MM during the first 10 years of follow-up was similar... (More)
The age-adjusted incidence of multiple myeloma (MM) is 2-fold higher in African Americans than in whites. A few small studies have reported a higher prevalence of monoclonal gammopathy of undetermined significance (MGUS) in African Americans versus whites. Etiologic factors for MGUS and determinants for transformation of MGUS to MM are unknown. We quantified the prevalence of MGUS and subsequent risk of MM among 4 million African American and white male veterans admitted to Veterans Affairs (VA) hospitals. The age-adjusted prevalence ratio of MGUS in African Americans compared with whites was 3.0 (2.7-3.3 95% confidence interval). Among 2046 MGUS cases, the estimated cumulative risk of MM during the first 10 years of follow-up was similar (P = .37) for African Americans (17%) and whites (15%). In the largest study to date, we suggest that the excess risk of MM in African Americans results from an increase in risk of MGUS rather than an increased risk of progression from MGUS to MM. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
107
issue
3
pages
904 - 906
publisher
American Society of Hematology
external identifiers
  • wos:000234991600020
  • pmid:16210333
  • scopus:31544457055
ISSN
1528-0020
DOI
10.1182/blood-2005-08-3449
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
id
421b23fd-855b-48e4-b3cc-4c6b50e9d5d3 (old id 419534)
date added to LUP
2016-04-01 12:20:31
date last changed
2019-12-10 02:39:12
@article{421b23fd-855b-48e4-b3cc-4c6b50e9d5d3,
  abstract     = {The age-adjusted incidence of multiple myeloma (MM) is 2-fold higher in African Americans than in whites. A few small studies have reported a higher prevalence of monoclonal gammopathy of undetermined significance (MGUS) in African Americans versus whites. Etiologic factors for MGUS and determinants for transformation of MGUS to MM are unknown. We quantified the prevalence of MGUS and subsequent risk of MM among 4 million African American and white male veterans admitted to Veterans Affairs (VA) hospitals. The age-adjusted prevalence ratio of MGUS in African Americans compared with whites was 3.0 (2.7-3.3 95% confidence interval). Among 2046 MGUS cases, the estimated cumulative risk of MM during the first 10 years of follow-up was similar (P = .37) for African Americans (17%) and whites (15%). In the largest study to date, we suggest that the excess risk of MM in African Americans results from an increase in risk of MGUS rather than an increased risk of progression from MGUS to MM.},
  author       = {Landgren, O and Gridley, G and Turesson, Ingemar and Caporaso, NE and Goldin, LR and Baris, D and Fears, TR and Hoover, RN and Linet, MS},
  issn         = {1528-0020},
  language     = {eng},
  number       = {3},
  pages        = {904--906},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States},
  url          = {http://dx.doi.org/10.1182/blood-2005-08-3449},
  doi          = {10.1182/blood-2005-08-3449},
  volume       = {107},
  year         = {2006},
}