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Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study.

Olanow, C Warren; Kieburtz, Karl; Odin, Per LU ; Espay, Alberto J; Standaert, David G; Fernandez, Hubert H; Vanagunas, Arvydas; Othman, Ahmed A; Widnell, Katherine L and Robieson, Weining Z, et al. (2014) In Lancet Neurology 13(2). p.141-149
Abstract
Levodopa is the most effective therapy for Parkinson's disease, but chronic treatment is associated with the development of potentially disabling motor complications. Experimental studies suggest that motor complications are due to non-physiological, intermittent administration of the drug, and can be reduced with continuous delivery. We aimed to assess efficacy and safety of levodopa-carbidopa intestinal gel delivered continuously through an intrajejunal percutaneous tube.
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Contribution to journal
publication status
published
subject
in
Lancet Neurology
volume
13
issue
2
pages
141 - 149
publisher
Lancet Ltd
external identifiers
  • pmid:24361112
  • wos:000330546200009
  • scopus:84892516916
ISSN
1474-4465
DOI
10.1016/S1474-4422(13)70293-X
language
English
LU publication?
yes
id
4eecb177-b554-4e6f-8c5b-c1565e425994 (old id 4223335)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24361112?dopt=Abstract
date added to LUP
2014-01-05 22:57:38
date last changed
2017-11-19 03:15:08
@article{4eecb177-b554-4e6f-8c5b-c1565e425994,
  abstract     = {Levodopa is the most effective therapy for Parkinson's disease, but chronic treatment is associated with the development of potentially disabling motor complications. Experimental studies suggest that motor complications are due to non-physiological, intermittent administration of the drug, and can be reduced with continuous delivery. We aimed to assess efficacy and safety of levodopa-carbidopa intestinal gel delivered continuously through an intrajejunal percutaneous tube.},
  author       = {Olanow, C Warren and Kieburtz, Karl and Odin, Per and Espay, Alberto J and Standaert, David G and Fernandez, Hubert H and Vanagunas, Arvydas and Othman, Ahmed A and Widnell, Katherine L and Robieson, Weining Z and Pritchett, Yili and Chatamra, Krai and Benesh, Janet and Lenz, Robert A and Antonini, Angelo},
  issn         = {1474-4465},
  language     = {eng},
  number       = {2},
  pages        = {141--149},
  publisher    = {Lancet Ltd},
  series       = {Lancet Neurology},
  title        = {Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study.},
  url          = {http://dx.doi.org/10.1016/S1474-4422(13)70293-X},
  volume       = {13},
  year         = {2014},
}