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Active signals, gradient formation and regional specificity in neural induction.

Pera, Edgar LU ; Acosta, Helena LU ; Gouignard, Nadège LU ; Climent, Maria LU and Arregi, Igor LU (2014) In Experimental Cell Research 321(1). p.25-31
Abstract
The question of how the vertebrate embryo gives rise to a nervous system is of paramount interest in developmental biology. Neural induction constitutes the earliest step in this process and is tightly connected with development of the embryonic body axes. In the Xenopus embryo, perpendicular gradients of BMP and Wnt signals pattern the dorsoventral and anteroposterior body axes. Both pathways need to be inhibited to allow anterior neural induction to occur. FGF8 and IGF are active neural inducers that together with BMP and Wnt signals are integrated at the level of Smad 1/5/8 phosphorylation. Hedgehog (Hh) also contributes to anterior neural induction. Suppressor-of-fused plays an important role in intertwining the Hh and Wnt pathways.... (More)
The question of how the vertebrate embryo gives rise to a nervous system is of paramount interest in developmental biology. Neural induction constitutes the earliest step in this process and is tightly connected with development of the embryonic body axes. In the Xenopus embryo, perpendicular gradients of BMP and Wnt signals pattern the dorsoventral and anteroposterior body axes. Both pathways need to be inhibited to allow anterior neural induction to occur. FGF8 and IGF are active neural inducers that together with BMP and Wnt signals are integrated at the level of Smad 1/5/8 phosphorylation. Hedgehog (Hh) also contributes to anterior neural induction. Suppressor-of-fused plays an important role in intertwining the Hh and Wnt pathways. Distinct mechanisms are discussed that establish morphogen gradients and integrate retinoic acid and FGF signals during posterior development. These findings not only improve our understanding of regional specification in neural induction, but have profound implications for mammalian stem cell research and regenerative medicine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Cell Research
volume
321
issue
1
pages
25 - 31
publisher
Academic Press
external identifiers
  • pmid:24315941
  • wos:000331157200005
  • scopus:84892506734
ISSN
1090-2422
DOI
10.1016/j.yexcr.2013.11.018
language
English
LU publication?
yes
id
a2323d8f-e896-4643-9b3c-76d3ecc326fe (old id 4225049)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24315941?dopt=Abstract
date added to LUP
2014-01-03 14:10:22
date last changed
2017-07-02 03:25:55
@article{a2323d8f-e896-4643-9b3c-76d3ecc326fe,
  abstract     = {The question of how the vertebrate embryo gives rise to a nervous system is of paramount interest in developmental biology. Neural induction constitutes the earliest step in this process and is tightly connected with development of the embryonic body axes. In the Xenopus embryo, perpendicular gradients of BMP and Wnt signals pattern the dorsoventral and anteroposterior body axes. Both pathways need to be inhibited to allow anterior neural induction to occur. FGF8 and IGF are active neural inducers that together with BMP and Wnt signals are integrated at the level of Smad 1/5/8 phosphorylation. Hedgehog (Hh) also contributes to anterior neural induction. Suppressor-of-fused plays an important role in intertwining the Hh and Wnt pathways. Distinct mechanisms are discussed that establish morphogen gradients and integrate retinoic acid and FGF signals during posterior development. These findings not only improve our understanding of regional specification in neural induction, but have profound implications for mammalian stem cell research and regenerative medicine.},
  author       = {Pera, Edgar and Acosta, Helena and Gouignard, Nadège and Climent, Maria and Arregi, Igor},
  issn         = {1090-2422},
  language     = {eng},
  number       = {1},
  pages        = {25--31},
  publisher    = {Academic Press},
  series       = {Experimental Cell Research},
  title        = {Active signals, gradient formation and regional specificity in neural induction.},
  url          = {http://dx.doi.org/10.1016/j.yexcr.2013.11.018},
  volume       = {321},
  year         = {2014},
}