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A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

Speedy, Helen E; Di Bernardo, Maria Chiara; Sava, Georgina P; Dyer, Martin J S; Holroyd, Amy; Wang, Yufei; Sunter, Nicola J; Mansouri, Larry; Juliusson, Gunnar LU and Smedby, Karin E, et al. (2014) In Nature Genetics 46(1). p.56-56
Abstract
Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7))... (More)
Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL. (Less)
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Nature Genetics
volume
46
issue
1
pages
56 - 56
publisher
Nature Publishing Group
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  • wos:000329113500013
  • pmid:24292274
  • scopus:84891371778
ISSN
1546-1718
DOI
10.1038/ng.2843
language
English
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yes
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e1369ee9-f63b-414e-93f2-d300a26a87ea (old id 4225448)
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http://www.ncbi.nlm.nih.gov/pubmed/24292274?dopt=Abstract
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2014-01-02 21:15:36
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2017-10-29 03:07:51
@article{e1369ee9-f63b-414e-93f2-d300a26a87ea,
  abstract     = {Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.},
  author       = {Speedy, Helen E and Di Bernardo, Maria Chiara and Sava, Georgina P and Dyer, Martin J S and Holroyd, Amy and Wang, Yufei and Sunter, Nicola J and Mansouri, Larry and Juliusson, Gunnar and Smedby, Karin E and Roos, Göran and Jayne, Sandrine and Majid, Aneela and Dearden, Claire and Hall, Andrew G and Mainou-Fowler, Tryfonia and Jackson, Graham H and Summerfield, Geoffrey and Harris, Robert J and Pettitt, Andrew R and Allsup, David J and Bailey, James R and Pratt, Guy and Pepper, Chris and Fegan, Chris and Rosenquist, Richard and Catovsky, Daniel and Allan, James M and Houlston, Richard S},
  issn         = {1546-1718},
  language     = {eng},
  number       = {1},
  pages        = {56--56},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.},
  url          = {http://dx.doi.org/10.1038/ng.2843},
  volume       = {46},
  year         = {2014},
}