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RIFM fragrance ingredient safety assessment, Isopulegol, CAS Registry Number 89-79-2

Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M. LU ; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L. and La Cava, S., et al. (2016) In Food and Chemical Toxicology 97. p.129-135
Abstract

This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

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type
Contribution to journal
publication status
published
subject
keywords
Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
in
Food and Chemical Toxicology
volume
97
pages
129 - 135
publisher
Elsevier
external identifiers
  • scopus:84994201675
ISSN
0278-6915
DOI
10.1016/j.fct.2016.08.001
language
English
LU publication?
no
id
42301092-d452-481b-80ed-00a4368292bd
date added to LUP
2016-12-12 12:35:16
date last changed
2017-03-30 14:50:42
@article{42301092-d452-481b-80ed-00a4368292bd,
  abstract     = {<p>This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.</p>},
  author       = {Api, A. M. and Belsito, D. and Bhatia, S. and Bruze, M. and Calow, P. and Dagli, M. L. and Dekant, W. and Fryer, A. D. and Kromidas, L. and La Cava, S. and Lalko, J. F. and Lapczynski, A. and Liebler, D. C. and Penning, T. M. and Politano, V. T. and Ritacco, G. and Salvito, D. and Schultz, T. W. and Shen, J. and Sipes, I. G. and Wall, B. and Wilcox, D. K.},
  issn         = {0278-6915},
  keyword      = {Developmental and reproductive toxicity,Environmental safety,Genotoxicity,Local respiratory toxicity,Phototoxicity/photoallergenicity,Repeated dose,Skin sensitization},
  language     = {eng},
  month        = {11},
  pages        = {129--135},
  publisher    = {Elsevier},
  series       = {Food and Chemical Toxicology},
  title        = {RIFM fragrance ingredient safety assessment, Isopulegol, CAS Registry Number 89-79-2},
  url          = {http://dx.doi.org/10.1016/j.fct.2016.08.001},
  volume       = {97},
  year         = {2016},
}