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Simultaneous patch testing with fragrance mix I, fragrance mix II and their ingredients in southern Sweden between 2009 and 2015

Mowitz, Martin LU ; Svedman, Cecilia LU ; Zimerson, Erik LU ; Isaksson, Marléne LU ; Pontén, Ann LU and Bruze, Magnus LU (2017) In Contact Dermatitis
Abstract

Background: Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy. Objectives: To investigate the frequency of allergic reactions to FM I, FM II and their ingredients in consecutively patch tested patients. Materials and methods: A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed. Results: Of the patients, 6.5% were FM I-positive and 3.2% were FM II-positive. Forty-five per cent of FM I-positive patients did not have positive reactions to FM I ingredients. Thirty-five per cent of those who were FM II-positive did not have positive reactions to FM II ingredients. Twenty-seven per cent of those... (More)

Background: Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy. Objectives: To investigate the frequency of allergic reactions to FM I, FM II and their ingredients in consecutively patch tested patients. Materials and methods: A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed. Results: Of the patients, 6.5% were FM I-positive and 3.2% were FM II-positive. Forty-five per cent of FM I-positive patients did not have positive reactions to FM I ingredients. Thirty-five per cent of those who were FM II-positive did not have positive reactions to FM II ingredients. Twenty-seven per cent of those with positive reactions to one or more of the FM I ingredients were FM I-negative, and 36% of those who had positive reactions to one or more of the FM II ingredients were FM II-negative. The allergens with the highest pick-up rates were Evernia prunastri (1.8%), cinnamal (1.3%), citral (1.2%), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (1.2%). Significant differences were observed in the proportions of positive reactions to FM I, FM II, eugenol, isoeugenol, and farnesol when results from patch testing with materials from different suppliers were compared. Conclusions: There is a risk of missing fragrance contact allergy when testing with only the fragrance mixes is performed. The use of preparations from different suppliers may affect the patch test results.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Batch variation, Contact allergy, Fragrance mix I, Fragrance mix II, Patch test
in
Contact Dermatitis
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85022059819
ISSN
0105-1873
DOI
10.1111/cod.12834
language
English
LU publication?
yes
id
4234444e-3123-4385-ab0f-1e710cd9e713
date added to LUP
2017-08-21 15:27:49
date last changed
2017-08-22 03:00:04
@article{4234444e-3123-4385-ab0f-1e710cd9e713,
  abstract     = {<p>Background: Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy. Objectives: To investigate the frequency of allergic reactions to FM I, FM II and their ingredients in consecutively patch tested patients. Materials and methods: A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed. Results: Of the patients, 6.5% were FM I-positive and 3.2% were FM II-positive. Forty-five per cent of FM I-positive patients did not have positive reactions to FM I ingredients. Thirty-five per cent of those who were FM II-positive did not have positive reactions to FM II ingredients. Twenty-seven per cent of those with positive reactions to one or more of the FM I ingredients were FM I-negative, and 36% of those who had positive reactions to one or more of the FM II ingredients were FM II-negative. The allergens with the highest pick-up rates were Evernia prunastri (1.8%), cinnamal (1.3%), citral (1.2%), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (1.2%). Significant differences were observed in the proportions of positive reactions to FM I, FM II, eugenol, isoeugenol, and farnesol when results from patch testing with materials from different suppliers were compared. Conclusions: There is a risk of missing fragrance contact allergy when testing with only the fragrance mixes is performed. The use of preparations from different suppliers may affect the patch test results.</p>},
  author       = {Mowitz, Martin and Svedman, Cecilia and Zimerson, Erik and Isaksson, Marléne and Pontén, Ann and Bruze, Magnus},
  issn         = {0105-1873},
  keyword      = {Batch variation,Contact allergy,Fragrance mix I,Fragrance mix II,Patch test},
  language     = {eng},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Simultaneous patch testing with fragrance mix I, fragrance mix II and their ingredients in southern Sweden between 2009 and 2015},
  url          = {http://dx.doi.org/10.1111/cod.12834},
  year         = {2017},
}