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Temporal Variation of Ljungan Virus Antibody Levels in Relation to Islet Autoantibodies and Possible Correlation to Childhood Type 1 Diabetes

Nilsson, Anna-Lena LU ; Lagerquist, Eliza; Lynch, Kristian LU ; Lernmark, Åke LU and Olov, Rolandsson (2009) In Open Pediatric Medicine Journal 3. p.61-66
Abstract
Viral infection may trigger islet autoimmunity, type 1diabetes (T1D), or both. Fluctuating population density of

bank voles as a putative reservoir of Ljungan virus has been claimed to be associated with variations in T1D incidence

rate (IR). We tested the hypothesis that Ljungan virus antibodies reflecting prior exposure(s) to the virus may be

associated with islet autoimmunity, childhood diabetes or both. Incident, 0-18y, T1D patients (n = 63) were studied along

with age and sample time matched controls (n = 126). The younger children (< 9 years) tended to have a higher incidence

rate during winter (IR = 67.6, 95%CI 41.9-103.5) compared to summer (IR = 33.6, 95%CI 15.3-63.9) months.... (More)
Viral infection may trigger islet autoimmunity, type 1diabetes (T1D), or both. Fluctuating population density of

bank voles as a putative reservoir of Ljungan virus has been claimed to be associated with variations in T1D incidence

rate (IR). We tested the hypothesis that Ljungan virus antibodies reflecting prior exposure(s) to the virus may be

associated with islet autoimmunity, childhood diabetes or both. Incident, 0-18y, T1D patients (n = 63) were studied along

with age and sample time matched controls (n = 126). The younger children (< 9 years) tended to have a higher incidence

rate during winter (IR = 67.6, 95%CI 41.9-103.5) compared to summer (IR = 33.6, 95%CI 15.3-63.9) months. The

proportion of children with high level antibodies against Ljungan virus (LVAb) were both younger compared to the rest of

the children (p < 0.002) and correlated with half yearly T1D IR (r = 0.78, p = 0.005). High level LVAb fluctuating with

season and correlating with T1D IR indicates that past exposure to Ljungan virus may be associated with T1D. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antibodies, Islet autoantibodies, Type 1 diabetes, Ljungan virus
in
Open Pediatric Medicine Journal
volume
3
pages
61 - 66
ISSN
1874-3099
DOI
10.2174/1874309900903010061
language
English
LU publication?
yes
id
79105760-52b1-4eba-86ab-710e7b772dbe (old id 4253408)
date added to LUP
2016-01-27 09:10:10
date last changed
2016-06-13 06:51:15
@article{79105760-52b1-4eba-86ab-710e7b772dbe,
  abstract     = {Viral infection may trigger islet autoimmunity, type 1diabetes (T1D), or both. Fluctuating population density of<br/><br>
bank voles as a putative reservoir of Ljungan virus has been claimed to be associated with variations in T1D incidence<br/><br>
rate (IR). We tested the hypothesis that Ljungan virus antibodies reflecting prior exposure(s) to the virus may be<br/><br>
associated with islet autoimmunity, childhood diabetes or both. Incident, 0-18y, T1D patients (n = 63) were studied along<br/><br>
with age and sample time matched controls (n = 126). The younger children (&lt; 9 years) tended to have a higher incidence<br/><br>
rate during winter (IR = 67.6, 95%CI 41.9-103.5) compared to summer (IR = 33.6, 95%CI 15.3-63.9) months. The<br/><br>
proportion of children with high level antibodies against Ljungan virus (LVAb) were both younger compared to the rest of<br/><br>
the children (p &lt; 0.002) and correlated with half yearly T1D IR (r = 0.78, p = 0.005). High level LVAb fluctuating with<br/><br>
season and correlating with T1D IR indicates that past exposure to Ljungan virus may be associated with T1D.},
  author       = {Nilsson, Anna-Lena and Lagerquist, Eliza and Lynch, Kristian and Lernmark, Åke and Olov, Rolandsson},
  issn         = {1874-3099},
  keyword      = {antibodies,Islet autoantibodies,Type 1 diabetes,Ljungan virus},
  language     = {eng},
  pages        = {61--66},
  series       = {Open Pediatric Medicine Journal},
  title        = {Temporal Variation of Ljungan Virus Antibody Levels in Relation to Islet Autoantibodies and Possible Correlation to Childhood Type 1 Diabetes},
  url          = {http://dx.doi.org/10.2174/1874309900903010061},
  volume       = {3},
  year         = {2009},
}