GASTRIC BYPASS SURGERY HAS GREATER EFFECT THAN CALORIE RESTRICTION ON INCRETIN RELEASE AND INSULIN SECRETION ALREADY ON POSTOP. DAY 1
(2015) IFSO 2015 In Obesity Surgery 25(Suppl 1). p.85-85- Abstract
- Background: Gastric bypass surgery (GBP) provokes rapid improvement of type 2 diabetes (T2D) prior to significant weight loss. This
has been attributed to altered secretion of the two incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP). Here we studied the effects of very low calorie diet (VLCD) vs. the immediate effects of GBP on
glycaemia and incretin release.
Methods: Eight T2D obese women and 8 obese controls (C) underwent mixed meal tests (MMT) 4 w before (MMT-4w), 1 day before
(MMT-1d), 1 day after (MMT+1d) and six weeks after (MMT+6w) gastric bypass. MMT-4w was performed before VLCD and MMT+1d
constituted the first postoperative meal. Glucose, insulin and... (More) - Background: Gastric bypass surgery (GBP) provokes rapid improvement of type 2 diabetes (T2D) prior to significant weight loss. This
has been attributed to altered secretion of the two incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP). Here we studied the effects of very low calorie diet (VLCD) vs. the immediate effects of GBP on
glycaemia and incretin release.
Methods: Eight T2D obese women and 8 obese controls (C) underwent mixed meal tests (MMT) 4 w before (MMT-4w), 1 day before
(MMT-1d), 1 day after (MMT+1d) and six weeks after (MMT+6w) gastric bypass. MMT-4w was performed before VLCD and MMT+1d
constituted the first postoperative meal. Glucose, insulin and incretins were analyzed. Gastric bypass surgery was standardized to a 50
cm biliary limb and 150 cm alimentary limb and a 5 cm gastric pouch.
OBES SURG (2015) 25 (Suppl 1):S1–S364 S85
Results: Despite similar glucose levels, the insulin response was markedly increased at MMT+1d, compared to MMT-4w and MMT-1d
(2.4- and 2.8-fold). At MMT+6w a more rapid rise was evident. GLP-1 levels were similar in all MMTs except MMT+6w where an
increased response was seen; this was stronger in T2D vs. C. The GIP-response was higher at MMT+1d, compared to MMT-4w and
MMT-1d (1.6- and 1.4-fold). The increased GIP-response was attenuated in C at MMT+6w, but still evident in T2D.
Conclusions: VLCD has minor impact on the parameters analyzed; rather GBP per se elicits an immediate stimulatory effect on insulin
and GIP levels in response to an MMT as first meal on day 1 after surgery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/425bd66d-57db-4387-bec2-0079384cc6c2
- author
- Berggren, Johan LU ; Lindqvist, Andreas LU ; Groop, Leif LU ; Hedenbro, Jan LU and Wierup, Nils LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Obesity Surgery
- volume
- 25
- issue
- Suppl 1
- article number
- O.521
- pages
- 85 - 85
- publisher
- Springer
- conference name
- IFSO 2015
- conference location
- Vienna, Austria
- conference dates
- 2015-08-26 - 2015-08-29
- ISSN
- 1708-0428
- language
- English
- LU publication?
- yes
- id
- 425bd66d-57db-4387-bec2-0079384cc6c2
- alternative location
- https://link.springer.com/content/pdf/10.1007%2Fs11695-015-1750-3.pdf
- date added to LUP
- 2016-11-23 09:15:53
- date last changed
- 2021-12-27 11:16:14
@misc{425bd66d-57db-4387-bec2-0079384cc6c2, abstract = {{Background: Gastric bypass surgery (GBP) provokes rapid improvement of type 2 diabetes (T2D) prior to significant weight loss. This<br/>has been attributed to altered secretion of the two incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent<br/>insulinotropic polypeptide (GIP). Here we studied the effects of very low calorie diet (VLCD) vs. the immediate effects of GBP on<br/>glycaemia and incretin release.<br/>Methods: Eight T2D obese women and 8 obese controls (C) underwent mixed meal tests (MMT) 4 w before (MMT-4w), 1 day before<br/>(MMT-1d), 1 day after (MMT+1d) and six weeks after (MMT+6w) gastric bypass. MMT-4w was performed before VLCD and MMT+1d<br/>constituted the first postoperative meal. Glucose, insulin and incretins were analyzed. Gastric bypass surgery was standardized to a 50<br/>cm biliary limb and 150 cm alimentary limb and a 5 cm gastric pouch.<br/>OBES SURG (2015) 25 (Suppl 1):S1–S364 S85<br/>Results: Despite similar glucose levels, the insulin response was markedly increased at MMT+1d, compared to MMT-4w and MMT-1d<br/>(2.4- and 2.8-fold). At MMT+6w a more rapid rise was evident. GLP-1 levels were similar in all MMTs except MMT+6w where an<br/>increased response was seen; this was stronger in T2D vs. C. The GIP-response was higher at MMT+1d, compared to MMT-4w and<br/>MMT-1d (1.6- and 1.4-fold). The increased GIP-response was attenuated in C at MMT+6w, but still evident in T2D.<br/>Conclusions: VLCD has minor impact on the parameters analyzed; rather GBP per se elicits an immediate stimulatory effect on insulin<br/>and GIP levels in response to an MMT as first meal on day 1 after surgery.}}, author = {{Berggren, Johan and Lindqvist, Andreas and Groop, Leif and Hedenbro, Jan and Wierup, Nils}}, issn = {{1708-0428}}, language = {{eng}}, note = {{Conference Abstract}}, number = {{Suppl 1}}, pages = {{85--85}}, publisher = {{Springer}}, series = {{Obesity Surgery}}, title = {{GASTRIC BYPASS SURGERY HAS GREATER EFFECT THAN CALORIE RESTRICTION ON INCRETIN RELEASE AND INSULIN SECRETION ALREADY ON POSTOP. DAY 1}}, url = {{https://link.springer.com/content/pdf/10.1007%2Fs11695-015-1750-3.pdf}}, volume = {{25}}, year = {{2015}}, }