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GASTRIC BYPASS SURGERY HAS GREATER EFFECT THAN CALORIE RESTRICTION ON INCRETIN RELEASE AND INSULIN SECRETION ALREADY ON POSTOP. DAY 1

Berggren, Johan LU ; Lindqvist, Andreas LU ; Groop, Leif LU ; Hedenbro, Jan LU and Wierup, Nils LU (2015) IFSO 2015 In Obesity Surgery 25(Suppl 1). p.85-85
Abstract
Background: Gastric bypass surgery (GBP) provokes rapid improvement of type 2 diabetes (T2D) prior to significant weight loss. This
has been attributed to altered secretion of the two incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP). Here we studied the effects of very low calorie diet (VLCD) vs. the immediate effects of GBP on
glycaemia and incretin release.
Methods: Eight T2D obese women and 8 obese controls (C) underwent mixed meal tests (MMT) 4 w before (MMT-4w), 1 day before
(MMT-1d), 1 day after (MMT+1d) and six weeks after (MMT+6w) gastric bypass. MMT-4w was performed before VLCD and MMT+1d
constituted the first postoperative meal. Glucose, insulin and... (More)
Background: Gastric bypass surgery (GBP) provokes rapid improvement of type 2 diabetes (T2D) prior to significant weight loss. This
has been attributed to altered secretion of the two incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP). Here we studied the effects of very low calorie diet (VLCD) vs. the immediate effects of GBP on
glycaemia and incretin release.
Methods: Eight T2D obese women and 8 obese controls (C) underwent mixed meal tests (MMT) 4 w before (MMT-4w), 1 day before
(MMT-1d), 1 day after (MMT+1d) and six weeks after (MMT+6w) gastric bypass. MMT-4w was performed before VLCD and MMT+1d
constituted the first postoperative meal. Glucose, insulin and incretins were analyzed. Gastric bypass surgery was standardized to a 50
cm biliary limb and 150 cm alimentary limb and a 5 cm gastric pouch.
OBES SURG (2015) 25 (Suppl 1):S1–S364 S85
Results: Despite similar glucose levels, the insulin response was markedly increased at MMT+1d, compared to MMT-4w and MMT-1d
(2.4- and 2.8-fold). At MMT+6w a more rapid rise was evident. GLP-1 levels were similar in all MMTs except MMT+6w where an
increased response was seen; this was stronger in T2D vs. C. The GIP-response was higher at MMT+1d, compared to MMT-4w and
MMT-1d (1.6- and 1.4-fold). The increased GIP-response was attenuated in C at MMT+6w, but still evident in T2D.
Conclusions: VLCD has minor impact on the parameters analyzed; rather GBP per se elicits an immediate stimulatory effect on insulin
and GIP levels in response to an MMT as first meal on day 1 after surgery. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity Surgery
volume
25
issue
Suppl 1
article number
O.521
pages
85 - 85
publisher
Springer
conference name
IFSO 2015
conference location
Vienna, Austria
conference dates
2015-08-26 - 2015-08-29
ISSN
1708-0428
language
English
LU publication?
yes
id
425bd66d-57db-4387-bec2-0079384cc6c2
alternative location
https://link.springer.com/content/pdf/10.1007%2Fs11695-015-1750-3.pdf
date added to LUP
2016-11-23 09:15:53
date last changed
2021-12-27 11:16:14
@misc{425bd66d-57db-4387-bec2-0079384cc6c2,
  abstract     = {{Background: Gastric bypass surgery (GBP) provokes rapid improvement of type 2 diabetes (T2D) prior to significant weight loss. This<br/>has been attributed to altered secretion of the two incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent<br/>insulinotropic polypeptide (GIP). Here we studied the effects of very low calorie diet (VLCD) vs. the immediate effects of GBP on<br/>glycaemia and incretin release.<br/>Methods: Eight T2D obese women and 8 obese controls (C) underwent mixed meal tests (MMT) 4 w before (MMT-4w), 1 day before<br/>(MMT-1d), 1 day after (MMT+1d) and six weeks after (MMT+6w) gastric bypass. MMT-4w was performed before VLCD and MMT+1d<br/>constituted the first postoperative meal. Glucose, insulin and incretins were analyzed. Gastric bypass surgery was standardized to a 50<br/>cm biliary limb and 150 cm alimentary limb and a 5 cm gastric pouch.<br/>OBES SURG (2015) 25 (Suppl 1):S1–S364 S85<br/>Results: Despite similar glucose levels, the insulin response was markedly increased at MMT+1d, compared to MMT-4w and MMT-1d<br/>(2.4- and 2.8-fold). At MMT+6w a more rapid rise was evident. GLP-1 levels were similar in all MMTs except MMT+6w where an<br/>increased response was seen; this was stronger in T2D vs. C. The GIP-response was higher at MMT+1d, compared to MMT-4w and<br/>MMT-1d (1.6- and 1.4-fold). The increased GIP-response was attenuated in C at MMT+6w, but still evident in T2D.<br/>Conclusions: VLCD has minor impact on the parameters analyzed; rather GBP per se elicits an immediate stimulatory effect on insulin<br/>and GIP levels in response to an MMT as first meal on day 1 after surgery.}},
  author       = {{Berggren, Johan and Lindqvist, Andreas and Groop, Leif and Hedenbro, Jan and Wierup, Nils}},
  issn         = {{1708-0428}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  number       = {{Suppl 1}},
  pages        = {{85--85}},
  publisher    = {{Springer}},
  series       = {{Obesity Surgery}},
  title        = {{GASTRIC BYPASS SURGERY HAS GREATER EFFECT THAN CALORIE RESTRICTION ON INCRETIN RELEASE AND INSULIN SECRETION ALREADY ON POSTOP. DAY 1}},
  url          = {{https://link.springer.com/content/pdf/10.1007%2Fs11695-015-1750-3.pdf}},
  volume       = {{25}},
  year         = {{2015}},
}