Single injections of apoA-I acutely improve in vivo glucose tolerance in insulin-resistant mice.
(2014) In Diabetologia 57(4). p.797-800- Abstract
- Apolipoprotein A-I (apoA-I), the main protein constituent of HDL, has a central role in the reverse cholesterol-transport pathway, which together with the anti-inflammatory properties of apoA-I/HDL provide cardioprotection. Recent findings of direct stimulation of glucose uptake in muscle by apoA-I/HDL suggest that altered apoA-I and HDL functionality may be a contributing factor to the development of diabetes. We have studied the in vivo effects of short treatments with human apoA-I in a high-fat diet fed mouse model. In addition to native apoA-I, we investigated the effects of the cardioprotective Milano variant (Arg173Cys).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4291087
- author
- Stenkula, Karin LU ; Lindahl, Maria LU ; Petrlova, Jitka LU ; Dalla-Riva, Jonathan LU ; Göransson, Olga LU ; Cushman, Sam LU ; Krupinska, Ewa LU ; Jones, Helena LU and Lagerstedt, Jens LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetologia
- volume
- 57
- issue
- 4
- pages
- 797 - 800
- publisher
- Springer
- external identifiers
-
- pmid:24442447
- wos:000332600700019
- scopus:84896082858
- pmid:24442447
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-014-3162-7
- language
- English
- LU publication?
- yes
- id
- d3a86a23-69d1-4622-b7de-edb0ad4ab2b9 (old id 4291087)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24442447?dopt=Abstract
- date added to LUP
- 2016-04-01 10:36:27
- date last changed
- 2024-05-06 15:51:09
@article{d3a86a23-69d1-4622-b7de-edb0ad4ab2b9, abstract = {{Apolipoprotein A-I (apoA-I), the main protein constituent of HDL, has a central role in the reverse cholesterol-transport pathway, which together with the anti-inflammatory properties of apoA-I/HDL provide cardioprotection. Recent findings of direct stimulation of glucose uptake in muscle by apoA-I/HDL suggest that altered apoA-I and HDL functionality may be a contributing factor to the development of diabetes. We have studied the in vivo effects of short treatments with human apoA-I in a high-fat diet fed mouse model. In addition to native apoA-I, we investigated the effects of the cardioprotective Milano variant (Arg173Cys).}}, author = {{Stenkula, Karin and Lindahl, Maria and Petrlova, Jitka and Dalla-Riva, Jonathan and Göransson, Olga and Cushman, Sam and Krupinska, Ewa and Jones, Helena and Lagerstedt, Jens}}, issn = {{1432-0428}}, language = {{eng}}, number = {{4}}, pages = {{797--800}}, publisher = {{Springer}}, series = {{Diabetologia}}, title = {{Single injections of apoA-I acutely improve in vivo glucose tolerance in insulin-resistant mice.}}, url = {{http://dx.doi.org/10.1007/s00125-014-3162-7}}, doi = {{10.1007/s00125-014-3162-7}}, volume = {{57}}, year = {{2014}}, }