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Single injections of apoA-I acutely improve in vivo glucose tolerance in insulin-resistant mice.

Stenkula, Karin LU ; Lindahl, Maria LU ; Petrlova, Jitka LU ; Dalla-Riva, Jonathan LU ; Göransson, Olga LU ; Cushman, Sam LU ; Krupinska, Ewa LU ; Jones, Helena LU and Lagerstedt, Jens LU (2014) In Diabetologia 57(4). p.797-800
Abstract
Apolipoprotein A-I (apoA-I), the main protein constituent of HDL, has a central role in the reverse cholesterol-transport pathway, which together with the anti-inflammatory properties of apoA-I/HDL provide cardioprotection. Recent findings of direct stimulation of glucose uptake in muscle by apoA-I/HDL suggest that altered apoA-I and HDL functionality may be a contributing factor to the development of diabetes. We have studied the in vivo effects of short treatments with human apoA-I in a high-fat diet fed mouse model. In addition to native apoA-I, we investigated the effects of the cardioprotective Milano variant (Arg173Cys).
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetologia
volume
57
issue
4
pages
797 - 800
publisher
Springer Verlag
external identifiers
  • pmid:24442447
  • wos:000332600700019
  • scopus:84896082858
ISSN
1432-0428
DOI
10.1007/s00125-014-3162-7
language
English
LU publication?
yes
id
d3a86a23-69d1-4622-b7de-edb0ad4ab2b9 (old id 4291087)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24442447?dopt=Abstract
date added to LUP
2014-02-07 22:42:46
date last changed
2017-10-22 03:19:00
@article{d3a86a23-69d1-4622-b7de-edb0ad4ab2b9,
  abstract     = {Apolipoprotein A-I (apoA-I), the main protein constituent of HDL, has a central role in the reverse cholesterol-transport pathway, which together with the anti-inflammatory properties of apoA-I/HDL provide cardioprotection. Recent findings of direct stimulation of glucose uptake in muscle by apoA-I/HDL suggest that altered apoA-I and HDL functionality may be a contributing factor to the development of diabetes. We have studied the in vivo effects of short treatments with human apoA-I in a high-fat diet fed mouse model. In addition to native apoA-I, we investigated the effects of the cardioprotective Milano variant (Arg173Cys).},
  author       = {Stenkula, Karin and Lindahl, Maria and Petrlova, Jitka and Dalla-Riva, Jonathan and Göransson, Olga and Cushman, Sam and Krupinska, Ewa and Jones, Helena and Lagerstedt, Jens},
  issn         = {1432-0428},
  language     = {eng},
  number       = {4},
  pages        = {797--800},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Single injections of apoA-I acutely improve in vivo glucose tolerance in insulin-resistant mice.},
  url          = {http://dx.doi.org/10.1007/s00125-014-3162-7},
  volume       = {57},
  year         = {2014},
}