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Short-term exercise-induced improvements in bone properties are for the most part not maintained during aging in hamsters.

Koistinen, Arto P; Halmesmäki, Esa P; Iivarinen, Jarkko T; Arokoski, Jari P A; Brama, Pieter A J; Jurvelin, Jukka S; Helminen, Heikki J and Isaksson, Hanna LU (2014) In Experimental Gerontology 51. p.46-53
Abstract
Physical exercise during growth affects composition, structure and mechanical properties of bone. In this study we investigated whether the beneficial effects of exercise during the early growth phase have long-lasting effects or not. Female Syrian golden hamsters (total n=152) were used in this study. Half of the hamsters had access to running wheels during their rapid growth phase (from 1 to 3months of age). The hamsters were sacrificed at the ages of 1, 3, 12, and 15months. The diaphysis of the mineralized humerus was analyzed with microCT and subjected to three-point-bending mechanical testing. The trabecular bone in the tibial metaphysis was also analyzed with microCT. The collagen matrix of the humerus bone was studied by tensile... (More)
Physical exercise during growth affects composition, structure and mechanical properties of bone. In this study we investigated whether the beneficial effects of exercise during the early growth phase have long-lasting effects or not. Female Syrian golden hamsters (total n=152) were used in this study. Half of the hamsters had access to running wheels during their rapid growth phase (from 1 to 3months of age). The hamsters were sacrificed at the ages of 1, 3, 12, and 15months. The diaphysis of the mineralized humerus was analyzed with microCT and subjected to three-point-bending mechanical testing. The trabecular bone in the tibial metaphysis was also analyzed with microCT. The collagen matrix of the humerus bone was studied by tensile testing after decalcification. The weight of the hamsters as well as the length of the bone and the volumetric bone mineral density (BMDvol) of the humerus was higher in the running group at the early age (3months). Moreover, the mineralized bone showed improved mechanical properties in humerus and had greater trabecular thickness in the subchondral bone of tibia in the runners. However, by the age of 12 and 15months, these differences were equalized with the sedentary group. The tensile strength and Young's modulus of decalcified humerus were higher in the runners at early stage, indicating a stronger collagen network. In tibial metaphysis, trabecular thickness was significantly higher for the runners in the old age groups (12 and 15months). Our study demonstrates that physical exercise during growth improves either directly or indirectly through weight gain bone properties of the hamsters. However, the beneficial effects were for the most part not maintained during aging. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Gerontology
volume
51
pages
46 - 53
publisher
Elsevier
external identifiers
  • pmid:24423444
  • wos:000331607800006
  • scopus:84893067405
ISSN
1873-6815
DOI
10.1016/j.exger.2013.12.017
language
English
LU publication?
yes
id
0c3cae6f-6e1e-47c2-8763-13a03f888a12 (old id 4291455)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24423444?dopt=Abstract
date added to LUP
2014-02-12 16:37:07
date last changed
2017-01-01 03:09:50
@article{0c3cae6f-6e1e-47c2-8763-13a03f888a12,
  abstract     = {Physical exercise during growth affects composition, structure and mechanical properties of bone. In this study we investigated whether the beneficial effects of exercise during the early growth phase have long-lasting effects or not. Female Syrian golden hamsters (total n=152) were used in this study. Half of the hamsters had access to running wheels during their rapid growth phase (from 1 to 3months of age). The hamsters were sacrificed at the ages of 1, 3, 12, and 15months. The diaphysis of the mineralized humerus was analyzed with microCT and subjected to three-point-bending mechanical testing. The trabecular bone in the tibial metaphysis was also analyzed with microCT. The collagen matrix of the humerus bone was studied by tensile testing after decalcification. The weight of the hamsters as well as the length of the bone and the volumetric bone mineral density (BMDvol) of the humerus was higher in the running group at the early age (3months). Moreover, the mineralized bone showed improved mechanical properties in humerus and had greater trabecular thickness in the subchondral bone of tibia in the runners. However, by the age of 12 and 15months, these differences were equalized with the sedentary group. The tensile strength and Young's modulus of decalcified humerus were higher in the runners at early stage, indicating a stronger collagen network. In tibial metaphysis, trabecular thickness was significantly higher for the runners in the old age groups (12 and 15months). Our study demonstrates that physical exercise during growth improves either directly or indirectly through weight gain bone properties of the hamsters. However, the beneficial effects were for the most part not maintained during aging.},
  author       = {Koistinen, Arto P and Halmesmäki, Esa P and Iivarinen, Jarkko T and Arokoski, Jari P A and Brama, Pieter A J and Jurvelin, Jukka S and Helminen, Heikki J and Isaksson, Hanna},
  issn         = {1873-6815},
  language     = {eng},
  pages        = {46--53},
  publisher    = {Elsevier},
  series       = {Experimental Gerontology},
  title        = {Short-term exercise-induced improvements in bone properties are for the most part not maintained during aging in hamsters.},
  url          = {http://dx.doi.org/10.1016/j.exger.2013.12.017},
  volume       = {51},
  year         = {2014},
}