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Impact of estrogen receptor beta activation on functional recovery after experimental stroke.

Madinier, Alexandre LU ; Wieloch, Tadeusz LU ; Olsson, Roger LU and Ruscher, Karsten LU (2014) In Behavioural Brain Research 261. p.282-288
Abstract
Acute treatment with 17β-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ERβ) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ERβ ligand 4-(1-phenyl-cyclohexyl)-phenol (AC-131) improves recovery of lost neurological function after permanent focal stroke induced by photothrombosis in adult Sprague-Dawley rats. Treatment was initiated on day 2 after photothrombosis and AC-131 (1, 10, and 50mg/kg) was administered by daily subcutaneous injections for 14 days. On day 2, 4, 6, 8, 11, 14, and 17 after photothrombosis,... (More)
Acute treatment with 17β-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ERβ) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ERβ ligand 4-(1-phenyl-cyclohexyl)-phenol (AC-131) improves recovery of lost neurological function after permanent focal stroke induced by photothrombosis in adult Sprague-Dawley rats. Treatment was initiated on day 2 after photothrombosis and AC-131 (1, 10, and 50mg/kg) was administered by daily subcutaneous injections for 14 days. On day 2, 4, 6, 8, 11, 14, and 17 after photothrombosis, functional deficits were assessed by the paw placement test, a standardized grip strength test and an adhesive removal test. Daily treatment with AC-131 significantly improved test scores in all three behavioral tests. Importantly, improved function was not associated with a decrease in infarct volume on day 17 after stroke onset. Our results suggest that increased activity of the ERβ is involved in mechanisms of stroke recovery. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Behavioural Brain Research
volume
261
pages
282 - 288
publisher
Elsevier
external identifiers
  • pmid:24406718
  • wos:000331497000035
  • scopus:84892454735
ISSN
0166-4328
DOI
10.1016/j.bbr.2013.12.046
language
English
LU publication?
yes
id
c840d53a-503c-49f5-b0d1-477f7736c951 (old id 4291735)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24406718?dopt=Abstract
date added to LUP
2014-02-06 23:08:03
date last changed
2017-11-12 03:08:51
@article{c840d53a-503c-49f5-b0d1-477f7736c951,
  abstract     = {Acute treatment with 17β-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ERβ) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ERβ ligand 4-(1-phenyl-cyclohexyl)-phenol (AC-131) improves recovery of lost neurological function after permanent focal stroke induced by photothrombosis in adult Sprague-Dawley rats. Treatment was initiated on day 2 after photothrombosis and AC-131 (1, 10, and 50mg/kg) was administered by daily subcutaneous injections for 14 days. On day 2, 4, 6, 8, 11, 14, and 17 after photothrombosis, functional deficits were assessed by the paw placement test, a standardized grip strength test and an adhesive removal test. Daily treatment with AC-131 significantly improved test scores in all three behavioral tests. Importantly, improved function was not associated with a decrease in infarct volume on day 17 after stroke onset. Our results suggest that increased activity of the ERβ is involved in mechanisms of stroke recovery.},
  author       = {Madinier, Alexandre and Wieloch, Tadeusz and Olsson, Roger and Ruscher, Karsten},
  issn         = {0166-4328},
  language     = {eng},
  pages        = {282--288},
  publisher    = {Elsevier},
  series       = {Behavioural Brain Research},
  title        = {Impact of estrogen receptor beta activation on functional recovery after experimental stroke.},
  url          = {http://dx.doi.org/10.1016/j.bbr.2013.12.046},
  volume       = {261},
  year         = {2014},
}