Impact of estrogen receptor beta activation on functional recovery after experimental stroke.
Madinier, Alexandre LU ; Wieloch, Tadeusz LU ; Olsson, Roger LU
and Ruscher, Karsten
LU
(2014)
In Behavioural Brain Research
261.
p.282-288
- Abstract
- Acute treatment with 17β-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ERβ) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ERβ ligand 4-(1-phenyl-cyclohexyl)-phenol (AC-131) improves recovery of lost neurological function after permanent focal stroke induced by photothrombosis in adult Sprague-Dawley rats. Treatment was initiated on day 2 after photothrombosis and AC-131 (1, 10, and 50mg/kg) was administered by daily subcutaneous injections for 14 days. On day 2, 4, 6, 8, 11, 14, and 17 after photothrombosis,... (More)
- Acute treatment with 17β-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ERβ) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ERβ ligand 4-(1-phenyl-cyclohexyl)-phenol (AC-131) improves recovery of lost neurological function after permanent focal stroke induced by photothrombosis in adult Sprague-Dawley rats. Treatment was initiated on day 2 after photothrombosis and AC-131 (1, 10, and 50mg/kg) was administered by daily subcutaneous injections for 14 days. On day 2, 4, 6, 8, 11, 14, and 17 after photothrombosis, functional deficits were assessed by the paw placement test, a standardized grip strength test and an adhesive removal test. Daily treatment with AC-131 significantly improved test scores in all three behavioral tests. Importantly, improved function was not associated with a decrease in infarct volume on day 17 after stroke onset. Our results suggest that increased activity of the ERβ is involved in mechanisms of stroke recovery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4291735
- author
- Madinier, Alexandre
LU
; Wieloch, Tadeusz
LU
; Olsson, Roger
LU
and Ruscher, Karsten
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Behavioural Brain Research
- volume
- 261
- pages
- 282 - 288
- publisher
- Elsevier
- external identifiers
-
- pmid:24406718
- wos:000331497000035
- scopus:84892454735
- pmid:24406718
- ISSN
- 0166-4328
- DOI
- 10.1016/j.bbr.2013.12.046
- language
- English
- LU publication?
- yes
- id
- c840d53a-503c-49f5-b0d1-477f7736c951 (old id 4291735)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24406718?dopt=Abstract
- date added to LUP
- 2016-04-01 10:31:31
- date last changed
- 2022-04-04 18:58:25
@article{c840d53a-503c-49f5-b0d1-477f7736c951,
abstract = {{Acute treatment with 17β-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ERβ) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ERβ ligand 4-(1-phenyl-cyclohexyl)-phenol (AC-131) improves recovery of lost neurological function after permanent focal stroke induced by photothrombosis in adult Sprague-Dawley rats. Treatment was initiated on day 2 after photothrombosis and AC-131 (1, 10, and 50mg/kg) was administered by daily subcutaneous injections for 14 days. On day 2, 4, 6, 8, 11, 14, and 17 after photothrombosis, functional deficits were assessed by the paw placement test, a standardized grip strength test and an adhesive removal test. Daily treatment with AC-131 significantly improved test scores in all three behavioral tests. Importantly, improved function was not associated with a decrease in infarct volume on day 17 after stroke onset. Our results suggest that increased activity of the ERβ is involved in mechanisms of stroke recovery.}},
author = {{Madinier, Alexandre and Wieloch, Tadeusz and Olsson, Roger and Ruscher, Karsten}},
issn = {{0166-4328}},
language = {{eng}},
pages = {{282--288}},
publisher = {{Elsevier}},
series = {{Behavioural Brain Research}},
title = {{Impact of estrogen receptor beta activation on functional recovery after experimental stroke.}},
url = {{http://dx.doi.org/10.1016/j.bbr.2013.12.046}},
doi = {{10.1016/j.bbr.2013.12.046}},
volume = {{261}},
year = {{2014}},
}