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Asthma control in patients on fixed dose combination evaluated with mannitol challenge test.

Romberg, Kerstin LU ; Berggren, Anna-Carin and Bjermer, Leif LU (2014) In Respiratory Medicine 108(2). p.264-270
Abstract
Asthma is often difficult to control and it is likely that not all patients are optimally treated. This study aimed to explore asthma control in adults receiving fixed dose combination (FDC) therapy. Control of asthma was assessed using the mannitol challenge test as a monitoring tool to see if this would give additional information compared to the asthma control test (ACT). The study was an open-label, prospective study on 98 adults prescribed with FDC therapies for at least three months. 74 patients considered that their asthma was well controlled. However, 60 patients had a positive mannitol challenge test (PD15 < 635 mg), and when those with a positive response to the short-acting β2-agonist (≥15%) after the mannitol challenge test... (More)
Asthma is often difficult to control and it is likely that not all patients are optimally treated. This study aimed to explore asthma control in adults receiving fixed dose combination (FDC) therapy. Control of asthma was assessed using the mannitol challenge test as a monitoring tool to see if this would give additional information compared to the asthma control test (ACT). The study was an open-label, prospective study on 98 adults prescribed with FDC therapies for at least three months. 74 patients considered that their asthma was well controlled. However, 60 patients had a positive mannitol challenge test (PD15 < 635 mg), and when those with a positive response to the short-acting β2-agonist (≥15%) after the mannitol challenge test were included, this increased to 64 patients (65%). Exploratory analysis determined that the spirometry parameters; FEV1/FVC and FEV1% of predicted, were statistically significant predictors of a positive mannitol challenge test. Co-morbid conditions such as concomitant upper airway involvement or eczema did not predict mannitol reactivity. Although most patients rated their asthma as well controlled, many provided a positive mannitol challenge test, suggesting the presence of underlying inflammation, despite treatment with fixed dose combination therapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Medicine
volume
108
issue
2
pages
264 - 270
publisher
Elsevier
external identifiers
  • pmid:24406244
  • wos:000331917000004
  • scopus:84893634791
ISSN
1532-3064
DOI
10.1016/j.rmed.2013.12.005
language
English
LU publication?
yes
id
3a85658f-2061-472c-81b0-3bd457ef35c0 (old id 4291742)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24406244?dopt=Abstract
date added to LUP
2014-02-08 23:28:43
date last changed
2017-01-01 03:39:31
@article{3a85658f-2061-472c-81b0-3bd457ef35c0,
  abstract     = {Asthma is often difficult to control and it is likely that not all patients are optimally treated. This study aimed to explore asthma control in adults receiving fixed dose combination (FDC) therapy. Control of asthma was assessed using the mannitol challenge test as a monitoring tool to see if this would give additional information compared to the asthma control test (ACT). The study was an open-label, prospective study on 98 adults prescribed with FDC therapies for at least three months. 74 patients considered that their asthma was well controlled. However, 60 patients had a positive mannitol challenge test (PD15 &lt; 635 mg), and when those with a positive response to the short-acting β2-agonist (≥15%) after the mannitol challenge test were included, this increased to 64 patients (65%). Exploratory analysis determined that the spirometry parameters; FEV1/FVC and FEV1% of predicted, were statistically significant predictors of a positive mannitol challenge test. Co-morbid conditions such as concomitant upper airway involvement or eczema did not predict mannitol reactivity. Although most patients rated their asthma as well controlled, many provided a positive mannitol challenge test, suggesting the presence of underlying inflammation, despite treatment with fixed dose combination therapy.},
  author       = {Romberg, Kerstin and Berggren, Anna-Carin and Bjermer, Leif},
  issn         = {1532-3064},
  language     = {eng},
  number       = {2},
  pages        = {264--270},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Asthma control in patients on fixed dose combination evaluated with mannitol challenge test.},
  url          = {http://dx.doi.org/10.1016/j.rmed.2013.12.005},
  volume       = {108},
  year         = {2014},
}