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The forced oscillation technique is a sensitive method for detecting obstructive airway disease in patients with primary Sjögren's syndrome.

NILSSON, ANNA LU ; Theander, Elke LU ; Hesselstrand, Roger LU ; Piitulainen, Eeva LU ; Wollmer, Per LU and Mandl, Thomas LU (2014) In Scandinavian Journal of Rheumatology 43(4). p.324-328
Abstract
Objectives: To study signs of obstructive airway disease (OAD) in patients with primary Sjögren's syndrome (pSS) using the forced oscillation technique (FOT). Method: Thirty-seven female pSS patients (median age 64, range 38-77 years) without previous physician-diagnosed OAD, participating in a longitudinal follow-up study of pulmonary function, and 74 female population-based controls (median age 64, range 47-77 years), also without physician-diagnosed OAD, and matched with regard to age, height, weight, and tobacco consumption, were included in the study. The pSS patients and controls were studied by the FOT, evaluating resistance and reactance of the respiratory system. Results: pSS patients had significantly increased resistances at... (More)
Objectives: To study signs of obstructive airway disease (OAD) in patients with primary Sjögren's syndrome (pSS) using the forced oscillation technique (FOT). Method: Thirty-seven female pSS patients (median age 64, range 38-77 years) without previous physician-diagnosed OAD, participating in a longitudinal follow-up study of pulmonary function, and 74 female population-based controls (median age 64, range 47-77 years), also without physician-diagnosed OAD, and matched with regard to age, height, weight, and tobacco consumption, were included in the study. The pSS patients and controls were studied by the FOT, evaluating resistance and reactance of the respiratory system. Results: pSS patients had significantly increased resistances at 5-25 Hz, decreased reactance at 10-35 Hz, and an increased resonant frequency (Fres) in comparison with controls. Resistance was correlated negatively and reactance positively to the vital capacity (VC), the forced expiratory volume in 1 s (FEV1), and the diffusing capacity for carbon monoxide (DLCO). Compared with controls, pSS patients with (n = 14) and without OAD (n = 21), as determined by spirometry, had significantly increased resistances at 5-25 Hz and decreased reactances at 10-35 Hz. In never-smoking subjects, identical FOT signs were found. Conclusions: pSS patients showed FOT signs of obstruction affecting both peripheral and central airways. pSS patients without spirometric signs of OAD and never-smoking pSS patients also showed clear FOT signs of obstruction. FOT therefore seems to be a sensitive method for detecting obstruction in pSS patients. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Rheumatology
volume
43
issue
4
pages
324 - 328
publisher
Taylor & Francis
external identifiers
  • pmid:24392743
  • wos:000340461800011
  • scopus:84905451736
ISSN
1502-7732
DOI
10.3109/03009742.2013.856466
language
English
LU publication?
yes
id
b2c43c94-f3d8-4ea9-a26d-95f98e5d4a2c (old id 4291995)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24392743?dopt=Abstract
date added to LUP
2014-02-08 11:03:38
date last changed
2017-04-16 03:24:03
@article{b2c43c94-f3d8-4ea9-a26d-95f98e5d4a2c,
  abstract     = {Objectives: To study signs of obstructive airway disease (OAD) in patients with primary Sjögren's syndrome (pSS) using the forced oscillation technique (FOT). Method: Thirty-seven female pSS patients (median age 64, range 38-77 years) without previous physician-diagnosed OAD, participating in a longitudinal follow-up study of pulmonary function, and 74 female population-based controls (median age 64, range 47-77 years), also without physician-diagnosed OAD, and matched with regard to age, height, weight, and tobacco consumption, were included in the study. The pSS patients and controls were studied by the FOT, evaluating resistance and reactance of the respiratory system. Results: pSS patients had significantly increased resistances at 5-25 Hz, decreased reactance at 10-35 Hz, and an increased resonant frequency (Fres) in comparison with controls. Resistance was correlated negatively and reactance positively to the vital capacity (VC), the forced expiratory volume in 1 s (FEV1), and the diffusing capacity for carbon monoxide (DLCO). Compared with controls, pSS patients with (n = 14) and without OAD (n = 21), as determined by spirometry, had significantly increased resistances at 5-25 Hz and decreased reactances at 10-35 Hz. In never-smoking subjects, identical FOT signs were found. Conclusions: pSS patients showed FOT signs of obstruction affecting both peripheral and central airways. pSS patients without spirometric signs of OAD and never-smoking pSS patients also showed clear FOT signs of obstruction. FOT therefore seems to be a sensitive method for detecting obstruction in pSS patients.},
  author       = {NILSSON, ANNA and Theander, Elke and Hesselstrand, Roger and Piitulainen, Eeva and Wollmer, Per and Mandl, Thomas},
  issn         = {1502-7732},
  language     = {eng},
  number       = {4},
  pages        = {324--328},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Rheumatology},
  title        = {The forced oscillation technique is a sensitive method for detecting obstructive airway disease in patients with primary Sjögren's syndrome.},
  url          = {http://dx.doi.org/10.3109/03009742.2013.856466},
  volume       = {43},
  year         = {2014},
}