Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity.
(2014) In Journal of Human Hypertension 28(7). p.456-460- Abstract
- Arterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment-insulin resistance (HOMA-IR), lipids and abdominal obesity. This study includes 335 subjects from Malmö, Sweden, examined in 1991-1994 and again at follow-up in 1998-2000 (mean age 64 years, 42% men). Ultrasound... (More)
- Arterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment-insulin resistance (HOMA-IR), lipids and abdominal obesity. This study includes 335 subjects from Malmö, Sweden, examined in 1991-1994 and again at follow-up in 1998-2000 (mean age 64 years, 42% men). Ultrasound measurement of the abdominal aorta was performed at follow-up investigation. In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (β=0.18, P=0.03) and a negative association between high-density lipoprotein and aortic stiffness (β=-0.23, P=0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.Journal of Human Hypertension advance online publication, 2 January 2014; doi:10.1038/jhh.2013.126. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4292209
- author
- Gottsäter, Mikael LU ; Länne, T and Nilsson, P M LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Human Hypertension
- volume
- 28
- issue
- 7
- pages
- 456 - 460
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:24384628
- wos:000338350600010
- scopus:84927174458
- pmid:24384628
- ISSN
- 1476-5527
- DOI
- 10.1038/jhh.2013.126
- language
- English
- LU publication?
- yes
- id
- 2bc1b0f0-705d-4f65-9595-515aa7184844 (old id 4292209)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24384628?dopt=Abstract
- date added to LUP
- 2016-04-01 10:04:02
- date last changed
- 2022-02-02 06:00:31
@article{2bc1b0f0-705d-4f65-9595-515aa7184844,
abstract = {{Arterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment-insulin resistance (HOMA-IR), lipids and abdominal obesity. This study includes 335 subjects from Malmö, Sweden, examined in 1991-1994 and again at follow-up in 1998-2000 (mean age 64 years, 42% men). Ultrasound measurement of the abdominal aorta was performed at follow-up investigation. In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (β=0.18, P=0.03) and a negative association between high-density lipoprotein and aortic stiffness (β=-0.23, P=0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.Journal of Human Hypertension advance online publication, 2 January 2014; doi:10.1038/jhh.2013.126.}},
author = {{Gottsäter, Mikael and Länne, T and Nilsson, P M}},
issn = {{1476-5527}},
language = {{eng}},
number = {{7}},
pages = {{456--460}},
publisher = {{Nature Publishing Group}},
series = {{Journal of Human Hypertension}},
title = {{Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity.}},
url = {{https://lup.lub.lu.se/search/files/1527844/4679526.pdf}},
doi = {{10.1038/jhh.2013.126}},
volume = {{28}},
year = {{2014}},
}