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Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity.

Gottsäter, Mikael LU ; Länne, T and Nilsson, P M (2014) In Journal of Human Hypertension 28(7). p.456-460
Abstract
Arterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment-insulin resistance (HOMA-IR), lipids and abdominal obesity. This study includes 335 subjects from Malmö, Sweden, examined in 1991-1994 and again at follow-up in 1998-2000 (mean age 64 years, 42% men). Ultrasound... (More)
Arterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment-insulin resistance (HOMA-IR), lipids and abdominal obesity. This study includes 335 subjects from Malmö, Sweden, examined in 1991-1994 and again at follow-up in 1998-2000 (mean age 64 years, 42% men). Ultrasound measurement of the abdominal aorta was performed at follow-up investigation. In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (β=0.18, P=0.03) and a negative association between high-density lipoprotein and aortic stiffness (β=-0.23, P=0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.Journal of Human Hypertension advance online publication, 2 January 2014; doi:10.1038/jhh.2013.126. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
Journal of Human Hypertension
volume
28
issue
7
pages
456 - 460
publisher
Nature Publishing Group
external identifiers
  • pmid:24384628
  • wos:000338350600010
  • scopus:84927174458
ISSN
1476-5527
DOI
10.1038/jhh.2013.126
language
English
LU publication?
yes
id
2bc1b0f0-705d-4f65-9595-515aa7184844 (old id 4292209)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24384628?dopt=Abstract
date added to LUP
2014-02-08 11:43:58
date last changed
2017-01-01 03:14:41
@article{2bc1b0f0-705d-4f65-9595-515aa7184844,
  abstract     = {Arterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment-insulin resistance (HOMA-IR), lipids and abdominal obesity. This study includes 335 subjects from Malmö, Sweden, examined in 1991-1994 and again at follow-up in 1998-2000 (mean age 64 years, 42% men). Ultrasound measurement of the abdominal aorta was performed at follow-up investigation. In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (β=0.18, P=0.03) and a negative association between high-density lipoprotein and aortic stiffness (β=-0.23, P=0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.Journal of Human Hypertension advance online publication, 2 January 2014; doi:10.1038/jhh.2013.126.},
  author       = {Gottsäter, Mikael and Länne, T and Nilsson, P M},
  issn         = {1476-5527},
  language     = {eng},
  number       = {7},
  pages        = {456--460},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Human Hypertension},
  title        = {Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity.},
  url          = {http://dx.doi.org/10.1038/jhh.2013.126},
  volume       = {28},
  year         = {2014},
}